Impact of Radiotherapy Concurrent with Anti-PD-1 Therapy on the Lung Tissue of Tumor-Bearing Mice [0.03%]
放疗联合抗PD-1免疫治疗对小鼠肿瘤肺组织的影响研究
Feng Wang,Yuan Luo,Xiaoli Tian et al.
Feng Wang et al.
Pneumonitis is a common adverse effect found in non-small cell lung cancer patients after radiotherapy or immune checkpoint inhibitor treatment. We investigated the effects of these two therapies, combined, in the lung tissue of an orthotop...
Late Effects of 16O-Particle Radiation on Female Social and Cognitive Behavior and Hippocampal Physiology [0.03%]
16O粒子辐射对雌性社交和认知行为及海马生理学的远期效应
Frederico Kiffer,Tyler Alexander,Julie E Anderson et al.
Frederico Kiffer et al.
The radiation environment in space remains a major concern for manned space exploration, as there is currently no shielding material capable of fully protecting flight crews. Additionally, there is growing concern for the social and cogniti...
RABiT-II: A Fully-Automated Micronucleus Assay System with Shortened Time to Result [0.03%]
改进的自动化微核检测系统RABiT-II及其快速模式
Mikhail Repin,Sergey Pampou,Guy Garty et al.
Mikhail Repin et al.
In this work, we describe a fully automated cytokinesis-block micronucleus (CBMN) assay with a significantly shortened time to result, motivated by the need for rapid high-throughput biodosimetric estimation of radiation doses from small-vo...
TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology [0.03%]
TOPAS-nBio：一种用于细胞和亚细胞放射生物学的TOPAS模拟工具包扩展
J Schuemann,A L McNamara,J Ramos-Méndez et al.
J Schuemann et al.
The TOPAS Monte Carlo (MC) system is used in radiation therapy and medical imaging research, having played a significant role in making Monte Carlo simulations widely available for proton therapy related research. While TOPAS provides detai...
Dose-Dependent Increase of Nrf2 Target Gene Expression in Mice Exposed to Ionizing Radiation [0.03%]
剂量依赖性增加小鼠辐照后核因子E2相关因子2靶基因的表达
Shuta Miura,Masaru Yamaguchi,Hironori Yoshino et al.
Shuta Miura et al.
Nuclear factor-erythroid-2-related factor 2 transcription factor (Nrf2) is activated by reactive oxygen species (ROS) and binds to antioxidant response elements in the promoter regions of its target genes involved in redox regulation and an...
Sara Dumit,Maia Avtandilashvili,Daniel J Strom et al.
Sara Dumit et al.
Individuals with significant intakes of plutonium (Pu) are typically treated with chelating agents, such as the trisodium salt form of calcium diethylenetriaminepentaacetate (CaNa3-DTPA, referred to hereafter as Ca-DTPA). Currently, there i...
Prominent Dose-Rate Effect and Its Age Dependence of Rat Mammary Carcinogenesis Induced by Continuous Gamma-Ray Exposure [0.03%]
连续γ射线照射大鼠乳腺的发病剂量率效应及其年龄依赖性研究
Tatsuhiko Imaoka,Mayumi Nishimura,Kazuhiro Daino et al.
Tatsuhiko Imaoka et al.
Although the risk of breast cancer after high-dose-rate irradiation has been firmly established, however, the risk incurred for low-dose-rate irradiation is not well understood. Here we provide experimental evidence for dose rate and age de...
Emerging Role of Secondary Bystander Effects Induced by Fractionated Proton Microbeam Radiation [0.03%]
分次质子微束辐射诱导二级旁观者效应的作用机制研究进展
Narongchai Autsavapromporn,Cuihua Liu,Alisa Kobayashi et al.
Narongchai Autsavapromporn et al.
Increased understanding of radiation-induced secondary bystander effect (RISBE) is relevant to radiation therapy since it likely contributes to normal tissue injury and tumor recurrence, subsequently resulting in treatment failure. In this ...
Effects of High- and Low-LET Radiation on Human Hematopoietic System Reconstituted in Immunodeficient Mice [0.03%]
人免疫缺陷小鼠重建造血系统中高、低 LET 辐射的生物学效应研究
Daniela Hoehn,Monica Pujol-Canadell,Erik F Young et al.
Daniela Hoehn et al.
Over the last 50 years, a number of important physiological changes in humans who have traveled on spaceflights have been catalogued. Of major concern are the short- and long-term radiation-induced injuries to the hematopoietic system that ...
Regulation through MicroRNAs in Response to Low-Energy N+ Ion Irradiation in Oryza sativa [0.03%]
低能N+离子辐照对水稻(Oryza sativa)microRNA调节的影响
Yalin Li,Weidong Wang,Tao Wang et al.
Yalin Li et al.
MicroRNAs (miRNAs) are a non-coding regulatory RNAs that play significant roles in plant growth and development, especially in the stress response. Low-energy ion radiation, a type of environmental stress, can cause multiple biological effe...