Effects of High- and Low-LET Radiation on Human Hematopoietic System Reconstituted in Immunodeficient Mice [0.03%]
人免疫缺陷小鼠重建造血系统中高、低 LET 辐射的生物学效应研究
Daniela Hoehn,Monica Pujol-Canadell,Erik F Young et al.
Daniela Hoehn et al.
Over the last 50 years, a number of important physiological changes in humans who have traveled on spaceflights have been catalogued. Of major concern are the short- and long-term radiation-induced injuries to the hematopoietic system that ...
Regulation through MicroRNAs in Response to Low-Energy N+ Ion Irradiation in Oryza sativa [0.03%]
低能N+离子辐照对水稻(Oryza sativa)microRNA调节的影响
Yalin Li,Weidong Wang,Tao Wang et al.
Yalin Li et al.
MicroRNAs (miRNAs) are a non-coding regulatory RNAs that play significant roles in plant growth and development, especially in the stress response. Low-energy ion radiation, a type of environmental stress, can cause multiple biological effe...
Experimental Assessment of Lithium Hydride's Space Radiation Shielding Performance and Monte Carlo Benchmarking [0.03%]
锂氢化物的空间辐射屏蔽性能实验评估及Monte Carlo基准计算
Christoph Schuy,Chiara La Tessa,Felix Horst et al.
Christoph Schuy et al.
The harmful effects of space radiation pose a serious health risk to astronauts participating in future long-term missions. Such radiation effects must be considered in the design phase of space vessels as well as in mission planning. Crew ...
Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca-/-) Mice [0.03%]
连续一年口服辐射缓解剂MMS350对全身体辐照后骨髓基质细胞增殖能力的恢复及Fanconi贫血（Fanca-/-）小鼠衰老的减少的影响研究
Aranee Sivananthan,Donna Shields,Renee Fisher et al.
Aranee Sivananthan et al.
We quantitated age-related accumulation of senescent cells in irradiated Fanconi anemia (FA) (Fanca-/- mouse cell lines in vitro, and monitored the effect of continuous administration (via drinking water) of the water-soluble radiation miti...
Specific Members of the Gut Microbiota are Reliable Biomarkers of Irradiation Intensity and Lethality in Large Animal Models of Human Health [0.03%]
大型人类健康动物模型中特定的肠道微生物是辐射强度和致死率的可靠生物标志物
Franck Carbonero,Alba Mayta,Mathilde Bolea et al.
Franck Carbonero et al.
The development of effective biomarkers for detecting the magnitude of radiation exposure and resiliency of host response is crucial to identifying appropriate treatment strategies after radiation exposure. We hypothesized that the gastroin...
Combined Effects of Low-Dose Proton Radiation and Simulated Microgravity on the Mouse Retina and the Hematopoietic System [0.03%]
低剂量质子辐射和模拟微重力对小鼠视网膜及造血系统的影响及其联合作用研究
X W Mao,M Boerma,D Rodriguez et al.
X W Mao et al.
The purpose of the current study was to characterize the effects of simulated microgravity and radiation-induced changes in retina and retinal vasculature, and to assess the accompanying early changes in immune cells and hematological param...
J Schuemann,A L McNamara,J W Warmenhoven et al.
J Schuemann et al.
Our understanding of radiation-induced cellular damage has greatly improved over the past few decades. Despite this progress, there are still many obstacles to fully understand how radiation interacts with biologically relevant cellular com...
Exposure to ≤15 cGy of 600 MeV/n 56Fe Particles Impairs Rule Acquisition but not Long-Term Memory in the Attentional Set-Shifting Assay [0.03%]
≤15 cGy 的 600 MeV/n 铁粒子照射损害注意集合转换实验中的规则获得但不影响长期记忆
Jessica S Jewell,Vania D Duncan,Arriyam Fesshaye et al.
Jessica S Jewell et al.
On future missions into deep space, astronauts will be required to work more autonomously than on previous missions, and thus their ability to perform executive functions could be critical to mission success. In this study, we determined th...
UV-Radiation Response Proteins Reveal Undifferentiated Cutaneous Interfollicular Melanocytes with Hyperradiosensitivity to Differentiation at 0.05 Gy Radiotherapy Dose Fractions [0.03%]
紫外线反应蛋白揭示了未分化的皮肤间质黑素细胞在放射治疗剂量分割时向分化过度敏感（0.05戈瑞）
Per Fessé,Fredrik Qvarnström,Jan Nyman et al.
Per Fessé et al.
To date, the response activated in melanocytes by repeated genotoxic insults from radiotherapy has not been explored. We hypothesized that the molecular pathways involved in the response of melanocytes to ionizing radiation and ultraviolet ...
Michael N Cornforth,Bradford D Loucas
Michael N Cornforth
Most of the important biological effects associated with the exposure to ionizing radiations are mirrored at the chromosomal level. In all cases, changes in the levels of cytogenetic effects are associated with changes in absorbed dose, dos...