Radiation Chemical Yield of Hydroxyl Radicals for Accelerator-based Boron Neutron Capture Therapy: Dose Assessment of 10B(n,α)7Li Reaction Using Coumarin-3-Carboxilic Solution [0.03%]
加速器基质硼中子俘获治疗的羟自由基产额：采用香豆素-3-羧酸溶液评估10B（n，α）7Li反应剂量学分布
Tamon Kusumoto,Ryo Ogawara
Tamon Kusumoto
Evaluation of the characteristics of accelerator-based thermal neutron fields is recognized as an important issue when discussing the effectiveness of boron neutron capture therapy (BNCT). In this study, we propose that the radiation chemic...
DNA Strand Breaks Induced by Fast and Thermal Neutrons from YAYOI Research Reactor in the Presence and Absence of Boric Acid [0.03%]
硼酸存在时快中子和热中子诱发的DNA链断裂研究
Erdenetogtokh Jamsranjav,Atsushi Ito,Yoshinari Kato et al.
Erdenetogtokh Jamsranjav et al.
It is well known that neutrons have more damaging effects, with high relative biological effectiveness or a radiation weighting factor depending on neutron energy, compared to low-LET ionizing radiations. In the current work, we evaluated t...
Hematological Effects of Non-Homogenous Ionizing Radiation Exposure in a Non-Human Primate Model [0.03%]
非人灵长类动物模型的非均匀电离辐射照射的血液学效应
Isabel L Jackson,Allison Gibbs,Yannick Poirier et al.
Isabel L Jackson et al.
Detonation of a radiological or nuclear device in a major urban area will result in heterogenous radiation exposure, given to the significant shielding of the exposed population due to surrounding structures. Development of biodosimetry ass...
Maintenance of Near Normal Bone Mass and Architecture in Lethally Irradiated Female Mice following Adoptive Transfer with as few as 750 Purified Hematopoietic Stem Cells [0.03%]
lethally照射小鼠骨量及骨结构的造血干细胞过继移植研究
Richard T Deyhle Jr,Carmen P Wong,Stephen A Martin et al.
Richard T Deyhle Jr et al.
Total-body irradiation (TBI) followed by transfer of bone marrow cells from donors is routinely performed in immunology research and can be used to manipulate differentiation and/or function of bone cells. However, exposure to high-dose rad...
Covalent Modification of Amino Acids and Peptides Induced by Ionizing Radiation from an Electron Beam Linear Accelerator Used in Radiotherapy [0.03%]
医用电子直线加速器放射线引起的氨基酸和肽的共价修饰反应
Benjamin B Minkoff,Steven T Bruckbauer,Grzegorz Sabat et al.
Benjamin B Minkoff et al.
To identify modifications to amino acids that are directly induced by ionizing radiation, free amino acids and 3-residue peptides were irradiated using a linear accelerator (Linac) radiotherapy device. Mass spectrometry was performed to det...
Phuongmai Nguyen,Sudhanshu Shukla,Ryan Liu et al.
Phuongmai Nguyen et al.
Sirtuin 2 (SIRT2) plays a major role in aging, carcinogenesis and neurodegeneration. While it has been shown that SIRT2 is a mediator of stress-induced cell death, the mechanism remains unclear. In this study, we report the role of SIRT2 in...
A Theoretical Model for Predicting and Optimizing In Vitro Screening of Potential Targeted Alpha-Particle Therapy Drugs [0.03%]
体外筛选潜在靶向α粒子治疗药物的预测和优化的理论模型
Wenzong Ma,Xudong Wang,Weihao Liu et al.
Wenzong Ma et al.
One highly promising approach to cancer treatment, especially for tumors that have undergone micrometastasis, is targeted alpha-particle therapy (TAT). However, the development of a TAT drug has been impeded due to numerous unsuccessful att...
Use of a Humanized Mouse Model System in the Validation of Human Radiation Biodosimetry Standards [0.03%]
人辐射生物剂量标准验证中的人源化小鼠模型系统应用研究
Monica Pujol-Canadell,Erik Young,Lubomir Smilenov
Monica Pujol-Canadell
After a planned or unplanned radiation exposure, determination of absorbed dose has great clinical importance, informing treatment and triage decisions in the exposed individuals. Biodosimetry approaches allow for determination of dose in t...
Estimation of Radiation Doses to U.S. Military Test Participants from Nuclear Testing: A Comparison of Historical Film-Badge Measurements, Dose Reconstruction and Retrospective Biodosimetry [0.03%]
美国军事试验参与者核试验辐射剂量估算：历史胶片计量数据、剂量重建与回顾性生物剂量学测定比较研究
Steven L Simon,Susan M Bailey,Harold L Beck et al.
Steven L Simon et al.
Retrospective radiation dose estimations, whether based on physical or biological measurements, or on theoretical dose reconstruction, are limited in their precision and reliability, particularly for exposures that occurred many decades ago...
Comparative Study
Radiation research. 2019 Apr;191(4):297-310. DOI:10.1667/RR15247.1 2019
Automated Triage Radiation Biodosimetry: Integrating Imaging Flow Cytometry with High-Throughput Robotics to Perform the Cytokinesis-Block Micronucleus Assay [0.03%]
自动化分诊辐射生物剂量测定法：将成像流式细胞术与高通量机器人技术结合，以执行有丝分裂阻滞微核试验
Qi Wang,Matthew A Rodrigues,Mikhail Repin et al.
Qi Wang et al.
The cytokinesis-block micronucleus (CBMN) assay has become a fully-validated and standardized method for radiation biodosimetry. The assay is typically performed using microscopy, which is labor intensive, time consuming and impractical aft...