Proteomic Changes in Preterminal Serum Samples of Rhesus Macaques Exposed to Two Different Doses of Acute Lethal Total-body Gamma Radiation [0.03%]
急性致死全身γ射线辐射恒河猴在不同剂量照射下预终期血清蛋白组学变化分析
Alana D Carpenter,Issa Melendez-Miranda,Yaoxiang Li et al.
Alana D Carpenter et al.
Ionizing radiation exposure induces cellular and molecular damage, leading to a chain of events that results in tissue and organ injury. Proteomics studies help identify, validate, and quantify alterations in protein abundance downstream of...
Characterization of Two Stable Biodosimeters for Absorbed Ionizing Radiation Dose Estimation in Multiple Combined Injury Models [0.03%]
两种稳定的生物剂量计在多种复合伤模型中估算吸收电离辐射剂量的特征研究
Le Ma,Zhihe Hu,Yan Chen et al.
Le Ma et al.
Radiation damage and deposition caused by radiological or nuclear public health incidents (e.g., accidents or attacks) may lead to acute radiation syndrome and other complications. Accurate and effective radiation dose assessment is necessa...
Development of an Experimental Platform for Gamma Knife Radiosurgery in Mouse Brains [0.03%]
小鼠脑立体定向放射外科手术实验平台的建立与发展研究
Yueshan Feng,Jiaxing Yu,Lixin Xu et al.
Yueshan Feng et al.
The limited availability of post-Gamma Knife radiosurgery (GKRS) samples and the unsuitability of clinical GKRS devices for small animals highlight the need to develop devices that enable the application of a clinical GKRS device in mouse m...
Computational Modeling to Advance Novel Medical Isotopes for Radiotheranostics: A DOE-NIH Joint Workshop Executive Summary [0.03%]
美国能源部和国立卫生研究院联合研讨会专题总结：推进放射治疗诊断用新型医用同位素的计算模型研究
Jeffrey C Buchsbaum,Henry F VanBrocklin,Reinier Hernandez et al.
Jeffrey C Buchsbaum et al.
Maternal High-fat Diet Modulates Radiosensitivity of Hematopoietic Tissue in Male Offspring [0.03%]
高脂饮食可改变雄性后代造血组织的放射敏感性
Takanori Katsube,Masahiro Murakami,Kaoru Tanaka et al.
Takanori Katsube et al.
Obesity is a growing global health concern, and the Western diet characterized by its high-calorie and high-fat content, is widely acknowledged as a major contributor. Obesity is closely linked to the onset of various metabolic syndromes in...
Octamer-Binding Transcription Factor 4 Inhibits HSC Functions via the NF-κB Signaling Pathway After 60Co Irradiation [0.03%]
经60钴照射后八聚体结合转录因子4通过NF-κB信号途径抑制造血干细胞功能
Wenjing Yang,Xiaoe Jin,Chao Chen et al.
Wenjing Yang et al.
High doses of radiation can cause irreversible bone marrow hematopoietic damage and even death. No effective strategies have been developed to protect against radiation effects in hematopoietic stem cells (HSCs). A total-body irradiation mo...
Antioxidants Ameliorates Ionizing Radiation-Induced Microcephaly in Cerebral Organoid Derived from Human-induced Pluripotent Stem Cells [0.03%]
抗氧化剂改善了由人诱导多能干细胞衍生的脑类器官的小头畸形及放射引起的损伤
Mikio Shimada,Yoshihisa Matsumoto
Mikio Shimada
Ionizing radiation exposure induces DNA damage and chromosome aberrations through both direct and indirect effect. The indirect effects are primarily mediated by the generation of hydroxyl radicals, a process attributed to radiation. Dimeth...
The Radioprotective Effects of 16, 16 dimethyl Prostaglandin E2 on Survival and Hematopoiesis are Mediated Through Co-Stimulation of the EP3 and EP4 Receptors [0.03%]
16,16-二甲基前列腺素E2的放射保护作用通过EP3和EP4受体的协同刺激促进生存和造血作用实现
Seiji Fukuda,Andrea M Patterson,Tong Wu et al.
Seiji Fukuda et al.
16, 16 dimethyl-Prostaglandin E2 (dmPGE2) administered prior to lethal irradiation protects against mortality from the hematopoietic acute radiation syndrome (H-ARS). It protects hematopoietic stem (HSC) and progenitor (HPC) cells and accel...
Correlation Between DNA Double-Strand Break Distribution in 3D Genome and Ionizing Radiation-Induced Cell Death [0.03%]
DNA双链断裂在三维基因组中的分布与电离辐射诱导的细胞死亡之间的关系研究
Ankang Hu,Wanyi Zhou,Xiyu Luo et al.
Ankang Hu et al.
The target theory is the most classical hypothesis explaining radiation-induced cell death, yet the physical or biological nature of the "target" remains ambiguous. This study hypothesizes that the distribution of DNA double-strand breaks (...
A Murine Model of Radionuclide Lung Contamination for the Evaluation of Americium Decorporation Treatments [0.03%]
评价镅去污疗法的放射性核素污染肺的小鼠模型
Trevor Arino,Alexia G Cosby,Jennifer Alvarenga-Vasquez et al.
Trevor Arino et al.
The hydroxypyridinone ligand 3,4,3-LI(1,2-HOPO) (HOPO), has been previously characterized as a promising chelating agent for in vivo decorporation of actinides, with decorporation being the removal of internally deposited contaminants from ...