Dickkopf-1 Treatment Stimulates Hematopoietic Regenerative Function in Infused Endothelial Progenitor Cells [0.03%]
Dickkopf-1治疗可促进输入的内皮祖细胞的造血再生功能
Mindy M Kim,Lauren Schlussel,Liman Zhao et al.
Mindy M Kim et al.
Acute high-dose radiation injury damages the bone marrow hematopoietic stem and progenitor cell compartment. This damage compromises the functional ability of the bone marrow to produce mature blood cells and results in an increased risk of...
Use of Growth Factors and Other Cytokines for Treatment of Injuries During a Radiation Public Health Emergency [0.03%]
放射突发事件中治疗损伤用生长因子及其他细胞因子的使用
Andrea L DiCarlo,Zulmarie Perez Horta,Jennifer T Aldrich et al.
Andrea L DiCarlo et al.
Due to the threat of a radiological or nuclear incident that could impact citizens, the U.S. Department of Health and Human Services tasked the National Institute of Allergy and Infectious Diseases (NIAID) with identifying and funding early...
Dose, LET and Strain Dependence of Radiation-Induced 53BP1 Foci in 15 Mouse Strains Ex Vivo Introducing Novel DNA Damage Metrics [0.03%]
基于15个外遗传鼠株建立辐射诱导的新DNA损伤计量学指标：剂量、线性质商及品系依赖性研究
Sébastien Penninckx,Egle Cekanaviciute,Charlotte Degorre et al.
Sébastien Penninckx et al.
We present a comprehensive comparative analysis on the repair of radiation-induced DNA damage ex vivo in 15 strains of mice, including 5 inbred reference strains and 10 collaborative-cross strains, of both sexes, totaling 5 million skin fib...
Use of Growth Factors and Cytokines to Treat Injuries Resulting from a Radiation Public Health Emergency [0.03%]
放射所致公共卫生事件伤害的生长因子和细胞因子治疗研究进展及应用前景
Zulmarie Perez Horta,Cullen M Case Jr,Andrea L DiCarlo
Zulmarie Perez Horta
In response to concerns over possible radiological or nuclear incidents, the Radiation and Nuclear Countermeasures Program within the National Institute of Allergy and Infectious Diseases (NIAID) was tasked by the U.S. Department of Health ...
Transcriptional Profiling of Non-Human Primate Lymphoid Organ Responses to Total-Body Irradiation [0.03%]
非人灵长类动物全身辐照后淋巴器官转录组特征分析
David L Caudell,Kristofer T Michalson,Rachel N Andrews et al.
David L Caudell et al.
The global threat of exposure to radiation and its subsequent outcomes require the development of effective strategies to mitigate immune cell injury. In this study we explored transcriptional and immunophenotypic characteristics of lymphoi...
Characterization of Radioprotective, Radiomitigative and Bystander Signaling Modulating Effects of Endogenous Metabolites - Phenylacetate, Ursodeoxycholate and Tauroursodeoxycholate - on HCT116 Human Colon Carcinoma Cell Line [0.03%]
内源性代谢物（苯乙酸、乌本苷和牛磺熊去氧胆酸）对HCT116人结肠癌细胞系的放射保护、辐射减轻及旁观者信号调节作用的特征分析
Dusan Vukmirovic,Nguyen T K Vo,Colin Seymour et al.
Dusan Vukmirovic et al.
Exposures to ionizing radiation can cause depletion in stem cell reservoirs and lead to chronic injury processes that exacerbate carcinogenic and inflammatory responses. Therefore, radioprotective measures, against both acute and chronic bi...
Assessment of the Stability of Supraphysiological Ascorbate in Human Blood: Appropriate Handling of Samples from Clinical Trials for Measurements of Pharmacological Ascorbate [0.03%]
评估人体血液中超生理抗坏血酸稳定性的评价：临床试验样品的药理学抗坏血酸测量的适当处理方法
Michael S Petronek,Brett A Wagner,Nancy J Hollenbeck et al.
Michael S Petronek et al.
Based on encouraging results from several early-phase clinical trials, there is renewed interest in the use of pharmacological ascorbate (i.e., intravenous administration resulting in >≈10 mM plasma ascorbate concentrations) in combination...
Radiation-Induced Mitotic Catastrophe Enhanced by Gold Nanoparticles: Assessment with a Specific Automated Image Processing Workflow [0.03%]
辐射诱导的有丝分裂灾难由金纳米粒子增强：使用特定的自动化图像处理工作流程进行评估
Héna Paquot,Joël Daouk,Alicia Chateau et al.
Héna Paquot et al.
In recent years, the use of gold-based nanoparticles in radiotherapy has been extensively studied, and the associated radiosensitization mechanism has been evaluated in a variety of in vitro studies. Given that mitotic catastrophe is widely...
From Energy Deposition of Ionizing Radiation to Cell Damage Signaling: Benchmarking Simulations by Measured Yields of Initial DNA Damage after Ion Microbeam Irradiation [0.03%]
从离子辐射的能量沉积到细胞损伤信号传导：通过离子微束辐照后初始DNA损伤产额与测量结果进行基准比较的模拟研究
Géraldine Gonon,Carmen Villagrasa,Pascale Voisin et al.
Géraldine Gonon et al.
Advances in accelerator technology, which have enabled conforming radiotherapy with charged hadronic species, have brought benefits as well as potential new risks to patients. To better understand the effects of ionizing radiation on tumor ...
Adrenergic Receptor Signaling Regulates the Response of Tumors to Ionizing Radiation [0.03%]
肾上腺素受体信号调节肿瘤对电离辐射的反应
Cameron R MacDonald,Mark J Bucsek,Guanxi Qiao et al.
Cameron R MacDonald et al.
While ionizing radiation is a major form of cancer therapy, radioresistance remains a therapeutic obstacle. We have previously shown that the mandated housing temperature for laboratory mice (∼22°C) induces mild, but chronic, cold stress ...