Human Transcriptomic Response to Mixed Neutron-Photon Exposures Relevant to an Improvised Nuclear Device [0.03%]
与简易核装置相关的混合中子-光子照射的人体转录组反应
Sanjay Mukherjee,Veljko Grilj,Constantinos G Broustas et al.
Sanjay Mukherjee et al.
In the possible event of a detonation of an improvised nuclear device (IND), the immediate radiation would consist of both photons (gamma rays) and neutrons. Since neutrons generally have a high relative biological effectiveness (RBE) for m...
Rapid High-Throughput Diagnostic Triage after a Mass Radiation Exposure Event Using Early Gene Expression Changes [0.03%]
利用早期基因表达变化快速筛查大规模放射损伤受照者
Matthias Port,Patrick Ostheim,Matthäus Majewski et al.
Matthias Port et al.
Radiological exposure scenarios involving large numbers of people require a rapid and high-throughput method to identify the unexposed, and those exposed to low- and high-dose radiation. Those with high-dose exposure, e.g., >2 Gy and depend...
Adaptations to a Generalized Radiation Dose Reconstruction Methodology for Use in Epidemiologic Studies: An Update from the MD Anderson Late Effect Group [0.03%]
放射剂量重建方法在流行病学研究中的应用及适应性改良——M.D.安德森癌症中心放射损伤远期效应协作组的更新报告
Rebecca M Howell,Susan A Smith,Rita E Weathers et al.
Rebecca M Howell et al.
Epidemiologic studies that include patients who underwent radiation therapy for the treatment of cancer aim to quantify the relationship between radiotherapy and the risk of subsequent late effects. Because of the long follow-up period requ...
Reoxygenation and Repopulation of Tumor Cells after Ablative Hypofractionated Radiotherapy (SBRT and SRS) in Murine Tumors [0.03%]
大分割放射治疗(SBRT和SRS)诱导的乏氧及小鼠肿瘤细胞再增敏与复氧化
Chang W Song,Robert J Griffin,Yoon-Jin Lee et al.
Chang W Song et al.
In this work, we investigated the change in tumor microenvironment caused by semi-ablative high-dose irradiation and its implication on tumor cell survival, reoxygenation of hypoxic cells and repopulation in FSaII tumors grown subcutaneousl...
Biomolecular Analysis of Beta Dose-Dependent Cutaneous Radiation Injury in a Porcine Model [0.03%]
猪模型中β剂量依赖性皮肤辐射损伤的生物分子分析
Luke R Burnett,Alexis R Gabard,Mac Robinson et al.
Luke R Burnett et al.
While cutaneous radiation injury (CRI) is generally referenced as a consequence of a nuclear attack, it can also be caused by less dangerous events such as the use of dirty bombs, industrial radiological accidents, or accidental overexposur...
Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure [0.03%]
全身照射通过改变雄性食蟹猴单核细胞极化影响其放射损伤的机制研究
Kristofer T Michalson,Andrew N Macintyre,Gregory D Sempowski et al.
Kristofer T Michalson et al.
Radiation-induced fibrosis (RIF) is a common delayed effect of acute ionizing radiation exposure (DEARE) affecting diverse tissues including the heart, lungs, liver and skin, leading to reduced tissue function and increased morbidity. Monoc...
Stable Acinar Progenitor Cell Model Identifies Treacle-Dependent Radioresistance [0.03%]
稳定的小叶前体细胞模型鉴定出Treacle依赖的放射抵抗性
Thomas J Weber,Wei-Jun Qian,Jordan N Smith et al.
Thomas J Weber et al.
Radiotherapy for head and neck cancers can result in extensive damage to the salivary glands, significantly affecting patient quality of life. However, the salivary gland can recover in patients receiving lower doses of radiation. In additi...
Guthrie Miller,John A Klumpp,Deepesh Poudel et al.
Guthrie Miller et al.
In this work, a baseline compartmental model of the distribution and retention of americium in the rat for a systemic intake was derived. The model was derived from data obtained from a study designed to evaluate the behavior of americium i...
Age at Exposure to Radiation Determines Severity of Renal and Cardiac Disease in Rats [0.03%]
辐射暴露年龄决定大鼠肾病和心脏病的严重程度
Marek Lenarczyk,Amy Kronenberg,Marylou Mäder et al.
Marek Lenarczyk et al.
Radiotherapy with sparsely ionizing photons is a cornerstone of successful cancer treatment. Age at time of exposure to radiation is known to influence biological outcomes for many end points. The effect of dose and age at exposure upon the...
DMAPT is an Effective Radioprotector from Long-Term Radiation-Induced Damage to Normal Mouse Tissues In Vivo [0.03%]
DMAPT是一种有效的放射保护剂 可以减轻长期辐射对小鼠正常组织的损伤
Katherine L Morel,Rebecca J Ormsby,Sonja Klebe et al.
Katherine L Morel et al.
While radiotherapy is widely used in cancer treatment, the benefits can be limited by radiation-induced damage to neighboring healthy tissues. We previously demonstrated in mice that the anti-inflammatory compound dimethylaminoparthenolide ...