Radiation Biomarkers: Can Small Businesses Drive Accurate Radiation Precision Medicine? [0.03%]
辐射生物标志物：小型企业能否推动精确辐射精准医学？
Pataje G S Prasanna,Deepa Narayanan,Kehui Zhang et al.
Pataje G S Prasanna et al.
Radiation therapy is an essential component of cancer treatment. Currently, tumor control and normal tissue complication probabilities derived from a general patient population guide radiation treatment. Its outcome could be improved if rad...
Identification of Radiation-Dose-Dependent Expressive Genes in Individuals Exposed to External Ionizing Radiation [0.03%]
外照射辐射剂量依赖性表达基因的识别研究
Masaru Yamaguchi,Teruki Nishida,Yoshiaki Sato et al.
Masaru Yamaguchi et al.
For victims of radiological accidents, rapid dose estimation and damage prediction are essential. Administering the gold-standard biodosimetry chromosome aberration assay requires highly skilled individuals and several days of labor; conseq...
Delivery and Effectiveness of Carboplatin via Targeted Delivery Compared to Passive Accumulation of Intravenously Injected Particles Releasing Carboplatin upon Irradiation [0.03%]
主动辐射触发释放卡铂和被动注射卡铂的靶向输送的效果及作用机制比较研究
Takafumi Segawa,Satoshi Harada,Takahiro Sato et al.
Takafumi Segawa et al.
In this study, nanoparticles that release anticancer drugs upon irradiation were developed. Here, MM46 and MM48 tumors in C3He/N mice were irradiated. Furthermore, the intravenously (i.v.) injected nanoparticles were tested for their abilit...
Comparative Study
Radiation research. 2020 Mar;193(3):263-273. DOI:10.1667/RR15357.1 2020
Carli B Jones,Catherine M Davis,Karen S Sfanos
Carli B Jones
Over the course of a lifetime, humans may be exposed to different types of radiation, typically in the form of low-linear energy transfer (LET) radiation, which is used, for example, in cancer treatment. In addition, astronauts may be expos...
KATP Channel Blocker Glibenclamide Prevents Radiation-Induced Lung Injury and Inhibits Radiation-Induced Apoptosis of Vascular Endothelial Cells by Increased Ca2+ Influx and Subsequent PKC Activation [0.03%]
钾通道阻断剂苯乙双胍通过增加钙离子内流和随后的蛋白激酶C活化预防辐射引起的肺损伤并抑制血管内皮细胞的辐射诱导凋亡
Penglin Xia,Kun Cao,Xuguang Hu et al.
Penglin Xia et al.
Radiation-induced lung injury (RILI) is a common and severe side effect of thoracic radiotherapy, which compromises patients' quality of life. Recent studies revealed that early vascular injury, especially microvascular damage, played a cen...
Pet Dogs with Subclinical Acute Radiodermatitis Experience Widespread Somatosensory Sensitization [0.03%]
亚临床急性放射性皮炎患者的宠物狗出现广泛的体感敏感化现象
Michael W Nolan,Krista L Kelsey,Masataka Enomoto et al.
Michael W Nolan et al.
Radiation-induced dermatitis (RID) is a common and painful complication of radiotherapy. When severe, radiation-associated pain (RAP) can reduce the efficacy of radiotherapy by limiting the radiation dose given, and/or necessitating breaks ...
Imaging and Dosimetry Study of Inter-fraction Setup Error in a Murine Xenograft Flank Tumor Radiation Model [0.03%]
小鼠移植皮下肿瘤放射模型的体位摆位误差的影像与剂量学研究
Emily J Smith,Erik J Tryggestad,Brett L Carlson et al.
Emily J Smith et al.
Modern small animal irradiation platforms provide for accurate delivery of radiation under 3D image guidance. However, leveraging these improvements currently comes at the cost of lower-throughput experimentation. Herein, we characterized s...
Nailfold Capillaroscopic Findings in an Orthopedic Surgeon: Reversible Abnormalities after the Cessation of Radiation Exposure [0.03%]
放射线暴露停止后的可逆改变——一个骨科医生的手甲襞微循环发现
Maria Maddalena Sirufo,Lia Ginaldi,Massimo De Martinis
Maria Maddalena Sirufo
Interventional fluoroscopy is a leading source of occupational ionizing radiation exposure for medical personnel. For example, orthopedic surgeons represent one occupation where the risk of exposure is large. This occupational hazard is the...
Case Reports
Radiation research. 2020 Mar;193(3):236-240. DOI:10.1667/RR15435.1 2020
Contrast-Enhanced Ultrasound to Detect Early Microvascular Changes in Skeletal Muscle after High-Dose Radiation Treatment [0.03%]
高强度放射治疗后对比增强超声检测骨骼肌早期微血管变化的能力
Nima Nabavizadeh,Yue Qi,Andy Kaempf et al.
Nima Nabavizadeh et al.
The biological response of normal tissue to high-dose radiation treatment remains poorly understood. Alterations to the microenvironment, specifically the microvasculature, have been implicated as a significant contributor to tumoral cytoto...
Macrophage-Mediated Bystander Effects after Different Irradiations through a p53-dependent Pathway [0.03%]
不同辐照后巨噬细胞介导的旁观者效应依赖于p53途径
Jiamei Fu,Lin Zhu,Wenzhi Tu et al.
Jiamei Fu et al.
The goal of this work was to elucidate the mechanisms of bystander effects outside the localized irradiation field and their potential hematological toxicity. In this study, an in vitro multicellular co-culture system was used to investigat...