NIAID Staff and Biodosimetry Blue Ribbon Panel Participants
NIAID Staff and Biodosimetry Blue Ribbon Panel Participants
In the face of emerging threats from natural disasters, nuclear accidents, and potential malicious use of radiation, the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) has created the "202...
Radiation-induced Brain Injury and the Protective Role of Oxytetracycline: A Multimodal Study Integrating Behavioral, Biochemical, Histopathological, and Spectroscopic Analyses [0.03%]
辐射诱导的脑损伤及 oxytetracycline 的保护作用：结合行为学、生物化学、病理组织学和光谱学分析的多模态研究
Oytun Erbaş,Mümin Alper Erdoğan,Bahattin Özkul et al.
Oytun Erbaş et al.
Radiation-induced brain injury (RIBI) continues to pose a significant clinical problem linked to neuroinflammation, oxidative stress, and neuronal death. This research evaluates the neuroprotective efficacy of oxytetracycline (OTC) in mitig...
G0/G1 Switch 2 Regulates Radiation Sensitivity of Human Head and Neck Cancer through a G1-lipid Checkpoint [0.03%]
G0/G1转换开关2通过G1脂质检查点调节人类头颈部癌的放射敏感性
Niritta Patel,Amanda L Kalen,Leon Isakov et al.
Niritta Patel et al.
Head and neck squamous cell carcinoma (HNSCC) resistance to radiotherapy has prompted a need to develop adaptive radiation therapy protocols to improve patient outcomes. This study investigates the hypothesis that lipid metabolism regulates...
Effects of Ultra-High Dose-Rate Radiotherapy (FLASH-RT) on the Hematopoietic and Immune Systems: An Animal Study [0.03%]
超高速率放疗(FLASH-RT)对造血系统和免疫系统影响的动物研究
Tosol Yu,Yujeong Yoon,Chul-Won Choi et al.
Tosol Yu et al.
Ultra-high dose-rate radiotherapy, also known as FLASH radiotherapy (FLASH-RT), reduces radiation-induced damage in several organs. This study aimed to compare the effects of FLASH-RT and conventional dose-rate radiotherapy (CONV-RT) at 3 G...
Promoted Misrejoining of X-ray Radiation-induced DNA Double-Strand Breaks in Novel DNA Ligase IV-Deficient Mouse Cells [0.03%]
新型DNA连接酶IV缺陷小鼠细胞中电离辐射诱导的DNA双链断裂受控错误重接的研究
Maiko Kawata,Kazunori Shiraishi,Izumi Satake et al.
Maiko Kawata et al.
DNA double-strand breaks (DSBs) are the most severe type of DNA damage in living organisms and are primarily repaired by two pathways: non-homologous end joining (NHEJ) and homologous recombination (HR). DNA ligase IV (LIG4) is essential fo...
Ferroptosis is a Pivotal Player in Radiation-induced Cell Death of Colorectal Cancer Cells [0.03%]
铁死亡在结直肠癌细胞辐射诱导的细胞死亡中的关键作用
Lisa Kerkhove,Febe Geirnaert,Jana Coppens et al.
Lisa Kerkhove et al.
Ferroptosis, an iron-dependent type of regulated cell death (RCD), has recently been associated with radiation efficacy. However, the impact of ferroptosis inducers (FINs) on colorectal cancer (CRC) cell lines varies tremendously. This stud...
Dynamic Metabolomics Atlas of Radiation-induced Liver Injury and Hepatocyte Proliferation Process in Rat [0.03%]
大鼠辐射性肝损伤及肝细胞增殖过程的动态代谢图谱分析
Qiaoyuan Wu,Liqing Li,Yuxin Wei et al.
Qiaoyuan Wu et al.
This study aims to elucidate the processes involved in radiation-induced liver injury and subsequent hepatocyte proliferation, and to identify novel metabolic profiles associated with progression of liver injury and hepatocyte proliferation...
Dynamic Metabolomics Atlas of Radiation-induced Liver Injury and Hepatocyte Proliferation Process in Rat [0.03%]
大鼠辐射性肝损伤和肝细胞增殖过程的动态代谢图谱研究
Qiaoyuan Wu,Liqing Li,Yuxin Wei et al.
Qiaoyuan Wu et al.
This study aims to elucidate the processes involved in radiation-induced liver injury and subsequent hepatocyte proliferation, and to identify novel metabolic profiles associated with progression of liver injury and hepatocyte proliferation...
Impact of Oxygen on DNA Damage Distribution in 3D Genome and its Correlation to Oxygen Enhancement Ratio after High-LET Irradiation [0.03%]
氧气对高LET辐射下三维基因组DNA损伤分布的影响及其与氧增强比的关系研究
Ankang Hu,Wanyi Zhou,Xiyu Luo et al.
Ankang Hu et al.
The variation of the oxygen enhancement ratio (OER) across linear energy transfer (LET) currently lacks a comprehensive mechanistic interpretation and a mechanistic model. Our earlier research revealed a significant correlation between the ...
Effects of Tanshinone IIA on Calcium Overload and Pyroptosis in Radiation-induced Heart Disease Evaluated in Vivo and in Vitro [0.03%]
基于体内外研究探讨丹参酮 ⅡA 对放射性心脏病钙超载及焦亡的影响
Yan-Ling Li,Gang Wang,Yan-Biao Shu et al.
Yan-Ling Li et al.
Radiation-induced heart disease (RIHD) has become an unavoidable and challenging problem that greatly impacts the outcomes of patients with tumors undergoing radiotherapy. Many studies have shown the positive effects of tanshinone IIA on ca...