The Impact of Tissue Type and Density on Dose Point Kernels for Patient-Specific Voxel-Wise Dosimetry: A Monte Carlo Investigation [0.03%]
基于组织类型和密度的剂量点核对患者特异性体素剂量学的影响：一种蒙特卡洛方法研究
Ashok Tiwari,Stephen A Gravesa,John Sunderland
Ashok Tiwari
We report the generation of dose point kernels for clinically-relevant radionuclide beta decays and monoenergetic electrons in various tissues to understand the impact of tissue type on dose point kernels. Currently available voxel-wise dos...
Transitioning from Gamma Rays to X Rays for Comparable Biomedical Research Irradiations: Energy Matters [0.03%]
从伽马射线过渡到X射线进行可比的生物医学研究辐照：能量的重要性
Yannick Poirier,Matthew D Belley,Mark W Dewhirst et al.
Yannick Poirier et al.
Many studies in biomedical research and various allied fields, in which cells or laboratory animals are exposed to radiation, rely on adequate radiation dose standardization for reproducibility and comparability of biological data. Due to i...
Comparative Study
Radiation research. 2020 Jun 1;193(6):506-511. DOI:10.1667/RADE-20-00039.1 2020
Blood RNA Integrity is a Direct and Simple Reporter of Radiation Exposure and Prognosis: A Pilot Study [0.03%]
一项试点研究：血液RNA完整性是辐射暴露和预后的直接而简单的报告人
Abdulnaser Alkhalil,John L Clifford,Robert Ball et al.
Abdulnaser Alkhalil et al.
In the event of a mass casualty radiation scenario, rapid assessment of patients' health and triage is required for optimal resource utilization. Identifying the level and extent of exposure as well as prioritization of care is extremely ch...
Gary T Barnes
Gary T Barnes
Potential Mechanisms for Protective Effect of D-Methionine on Plasmid DNA Damage Induced by Therapeutic Carbon Ions [0.03%]
D-甲硫氨酸对治疗用碳离子诱发的质粒DNA损伤保护作用的潜在机制研究
Katsunori Yogo,Chieko Murayama,Yoshiki Fujisawa et al.
Katsunori Yogo et al.
D-methionine (D-met), a dextrorotatory isoform of the amino acid L-methionine (L-met), can prevent oral mucositis and salivary hypofunction in mice exposed to radiation. However, the mechanism of its radioprotection is unclear, especially w...
MicroRNA Analysis of ATM-Deficient Cells Indicate PTEN and CCDN1 as Potential Biomarkers of Radiation Response [0.03%]
ATM缺陷细胞的微RNA分析表明PTEN和CCDN1是辐射反应的潜在生物标志物
Jane Bryant,Lisa White,Natasha Coen et al.
Jane Bryant et al.
Genetic and epigenetic profile changes associated with individual radiation sensitivity are well documented and have led to enhanced understanding of the mechanisms of the radiation-induced DNA damage response. However, the search continues...
A Simplified Calyculin A-Induced Premature Chromosome Condensation (PCC) Protocol for the Biodosimetric Analysis of High-Dose Exposure to Gamma Radiation [0.03%]
一种简化的瓜林胺A诱导的辐射高剂量照射外周血早熟染色体凝集检测方法
Mingzhu Sun,Jayne Moquet,Stephen Barnard et al.
Mingzhu Sun et al.
Chemical-induced premature chromosome condensation (PCC) is an alternative biodosimetry method to the gold-standard dicentric analysis for ionizing radiation. However, existing literature shows great variations in the experimental protocols...
Effect of Ionizing Radiation on Transcriptome during Neural Differentiation of Human Embryonic Stem Cells [0.03%]
离子辐射对人类胚胎干细胞神经分化过程中转录谱的影响
Burk W Loeliger,Christine Hanu,Irina V Panyutin et al.
Burk W Loeliger et al.
Human embryonic brain development is highly sensitive to ionizing radiation. However, detailed information on the mechanisms of this sensitivity is not available due to limited experimental data. In this study, differentiation of human embr...
Development of Novel Radiosensitizers through the National Cancer Institute's Small Business Innovation Research Program [0.03%]
美国国家癌症研究所中小企业创新研究计划新型放疗增敏剂的研发
Kaveh Zakeri,Deepa Narayanan,Pataje G S Prasanna et al.
Kaveh Zakeri et al.
While radiosensitizing chemotherapy has improved survival for several types of cancer, current chemoradiation regimens remain ineffective for many patients and have substantial toxicities. Given the strong need for the development of novel ...
Epidermal Keratinocyte Depletion during Five Weeks of Radiotherapy is Associated with DNA Double-Strand Break Foci, Cell Growth Arrest and Apoptosis: Evidence of Increasing Radioresponsiveness and Lack of Repopulation; the Number of Melanocytes Remains Unchanged [0.03%]
放射治疗五周内表皮角质形成细胞耗竭与DNA双链断裂、细胞增殖停滞和凋亡有关：放射敏感性增加的证据，缺乏再群体；黑素细胞数量不变
Ingela Turesson,Martin Simonsson,Ingegerd Hermansson et al.
Ingela Turesson et al.
During fractionated radiotherapy, epithelial cell populations are thought to decrease initially, followed by accelerated repopulation to compensate cell loss. However, previous findings in skin with daily 1.1 Gy dose fractions indicate cont...