Transient Oxygen Depletion and FLASH: Are We Ruling It Out Too Soon? [0.03%]
瞬时氧耗竭和FLASH：我们是否过早排除了它们？
George D D Jones,Jan Schuemann,Bethany Rothwell
George D D Jones
The contribution of transient oxygen depletion (TOD) to the FLASH effect has been challenged, primarily because measurements indicate both insufficient depletion rates and normal tissue oxygenation levels that are too high. We argue that th...
Underscoring the Effects of Proton Radiation on Neuronal Function in 2D and 3D In Vitro Cortical Tissue Models [0.03%]
质子辐射对二维和三维皮质组织模型中神经元功能影响的实验研究
Neal M Lojek,Nazli Bostanci,Paulo Henrique Borges et al.
Neal M Lojek et al.
Proton radiation is known to have detrimental neurological effects, but there is limited scientific understanding of these effects at the cellular and tissue levels. We leveraged our 3D in vitro cortical tissue model alongside 2D cortical c...
Characterization of the Sequence of Cytopenia after Total-body Irradiation using Unsupervised Machine Learning [0.03%]
无监督机器学习描述全身照射后的细胞减少序列特征
Rahul K Goyal,John L McManus,Matangi Gopalakrishnan
Rahul K Goyal
Hematopoietic acute radiation syndrome (H-ARS) elicits multidimensional effects, as total-body irradiation (TBI) induced myelosuppression results in distinct patterns of loss and recovery across blood cell lineages. This study aimed to char...
Investigating the Toxicity and Biodistribution of Boron-loaded Liposomes in Canine and Feline Models [0.03%]
载硼脂质体的毒性及生物分布的犬猫模型研究
M Heidari-Kharaji,Peter J Orto,T A Everett et al.
M Heidari-Kharaji et al.
Boron neutron capture therapy (BNCT) is a targeted cancer treatment that relies on the selective accumulation of boron-containing agents in tumor cells, followed by irradiation with low-energy neutrons to produce a cytotoxic reaction. Lipos...
Individualized Dose-volume Reconstruction Workflow for the Normal Tissues of Pediatric Patients Treated with Passive Scattering Proton Therapy [0.03%]
儿科患者受被动散射质子治疗的正常组织个体化剂量体积重建工作流程
Keith T Griffin,Jan Schuemann,Aimee L McNamara et al.
Keith T Griffin et al.
The United States National Cancer Institute has launched a large epidemiological cohort study comparing subsequent cancer risks from photon and proton radiotherapy in pediatric cancer patients. Clinical data, including electronic radiothera...
Low-dose Ionizing Radiation, a Protective Intervention to Mitigate Chronic Cerebral Hypoperfusion-induced Brain Damage and Cognitive Deficits in the Rat [0.03%]
低剂量电离辐射通过改善脑缺血损伤和认知障碍保护慢性脑低灌注的作用及机制研究
Valentin Beaufils,Fatima-Azzahra Dwiri,Julie Bécam et al.
Valentin Beaufils et al.
Vascular dementia is a leading cause of cognitive decline, with few effective treatment options currently available. Within the framework of hormesis, treatment with low-dose ionizing radiation (LDIR
Emerging Roles of Multiparametric Biodosimetry and Artificial Intelligence in Advancing Radiation Dose Assessment for Triage [0.03%]
生物参数 biodosimetry 和人工智能在辐射剂量评估中的新兴作用及未来发展趋势——以分类为例
Adayabalam S Balajee
Adayabalam S Balajee
Biodosimetry plays a crucial role in radiation emergency preparedness and response by enabling efficient allocation of medical resources through prioritization of individuals needing urgent care to improve survival outcomes. Because current...
Neuroprotective Effects of Melatonin on Neurotrophic, Apoptotic/Antiapoptotic and Inflammation Markers in the Rat Cerebrum and Cerebellum after Cranial Radiotherapy [0.03%]
褪黑素对放射性脑损伤大鼠大脑和小脑神经营养、凋亡/抗凋亡及炎症指标的保护作用研究
Fatih Hacımustafaoğlu,Serhat Aras,Yalçın Erzurumlu et al.
Fatih Hacımustafaoğlu et al.
This study aims to investigate the radioprotective effects of melatonin (MEL) against oxidative damage that may be caused by flattening filter (FF) and flattening filter-free (FFF) beam in the cerebrum and cerebellum of rat using various ge...
Molecular Mechanisms of FLASH Radiotherapy in Alleviating Lung Normal Tissue Injury: Insights from Single-Cell Sequencing [0.03%]
FLASH放射治疗减轻肺正常组织损伤的分子机制：单细胞测序的新见解
Ziyang Guo,Yin Luo,Jianxin Wang
Ziyang Guo
FLASH radiotherapy (FLASH-RT), with its ultra-high dose rate (≥40 Gy/s) that causes the "FLASH effect," significantly reduces normal tissue toxicity while maintaining tumor cytotoxicity, but its molecular mechanisms have not been fully elu...
Silencing GPx1 Synergizes with Ionizing Radiation to Enhance the Elimination of Leukemia Stem Cells [0.03%]
GPx1沉默与电离辐射协同增强白血病干细胞的清除作用
Yaoqi Gui,Jingsong Cheng,Yi Mo et al.
Yaoqi Gui et al.
Leukemia stem cells (LSCs) are a key factor leading to the recurrence and drug resistance in acute myeloid leukemia (AML). Notably, the persistence of radiotherapy-resistant LSCs has been identified as a critical determinant of post-hematop...