The Protective Effects of TLR2/NOD2 Combined Agonist CL429 on 14.1 MeV Neutron-Radiation Damage [0.03%]
TLR2/NOD2激动剂CL429对14.1MeV中子辐照损伤的保护作用研究
Xiaoting Lin,Qingwei Zhao,Yanlan Xiao et al.
Xiaoting Lin et al.
High-energy neutron radiation (HENR) induces severe cellular and tissue damage, yet effective prophylactic agents remain limited. In this study, the TLR2/NOD2 co-agonist CL429 was evaluated for its radioprotective potential against 14.1 MeV...
Trends in Dose to the Contralateral Breast from Breast Cancer Radiotherapy in the United States [0.03%]
美国乳腺癌放射治疗的对侧乳房剂量趋势
Choonsik Lee,David Borrego,Lene H S Veiga et al.
Choonsik Lee et al.
Contralateral breast (CB) cancer is the most common subsequent cancer among breast cancer survivors, and radiotherapy has been linked to CB cancer risk. The purpose of this work was to evaluate doses to subregions of the contralateral breas...
Senescence Under the Lens: X-ray vs. Proton Irradiation at Conventional and Ultra-High Dose Rate [0.03%]
衰老作用机制的再审视：常规及超高剂量率X射线与质子照射效应的比较研究
Marie-Eugénie De Meester,Hugo Paulus,Carine Michiels et al.
Marie-Eugénie De Meester et al.
Conventional radiotherapy based on X rays is used to treat more than 50% of cancers. Although effective, radiotherapy can damage healthy tissues around the tumor due to the X-ray dose deposition profile, as well as the safety margin needed ...
16,16 dimethyl-prostaglandin E2 Administration Prior to Lethal Irradiation Ameliorates Long-term Immune Suppression [0.03%]
致死照射前给予16,16-二甲基前列腺素E2改善长期免疫抑制
Tong Wu,P Artur Plett,Carol H Sampson et al.
Tong Wu et al.
Survivors of the hematopoietic acute radiation syndrome (H-ARS) face delayed effects of acute radiation exposure (DEARE), including chronic immune suppression and thymic involution, for which no effective countermeasures exist. We previousl...
Whole-Thorax Irradiation Induces Persistent T Cell Clonal Dysregulation in Pediatric Rhesus Macaques [0.03%]
全胸腔照射会导致恒河猴幼年期T细胞克隆调节紊乱并持续终生
Andrew N Macintyre,John D Olson,Gaya Balamayooran et al.
Andrew N Macintyre et al.
The thymus is critical for the development and selection of T cells with a diverse range of non-self-reactive antigen receptors. Both the thymus and circulating T cells can be damaged by acute exposure to ionizing radiation, leading to dose...
Multicentered Biospecimen Analyses after 4 Gy Sublethal Total Body Irradiation in Rhesus [0.03%]
接受4Gy亚致死全身照射后猕猴多中心样本分析
J Tyson McDonald,Claude J Rogers,Denise Nishita et al.
J Tyson McDonald et al.
In the event of a large-scale radiological emergency, delivering timely medical aid to individuals receiving potentially lethal doses of radiation will result in improved survival and decreased severity of injuries. While it may be possible...
The Impact of Dose, Sex, and Age at Time of Acute Whole-body Radiation Exposure on Long-term Hematopoiesis in Rhesus Macaques (Macaca mulatta) [0.03%]
剂量、性别和急性全身辐射照射时年龄对恒河猴终生造血的影响
Yuiko Chino,John D Olson,Stephen Aichele et al.
Yuiko Chino et al.
The hematopoietic system is highly sensitive to ionizing radiation exposure. Accumulating evidence from the Japanese A-bomb survivor cohort and animal studies suggests that radiation-induced damage to the hematopoietic system can persist lo...
Radiation Decreases Bone Density while Diabetes Increases Osteoarthritis in Non-Human Primates [0.03%]
辐射减少骨密度而糖尿病增加非人类灵长类动物的骨关节炎患病率
Nequesha S Mohamed,Nicole A Gagnon,Johannes F Plate et al.
Nequesha S Mohamed et al.
Total-body irradiation has long-term effects and may cause joint damage, especially in individuals with diabetes. Lowered bone mineral density and arthropathy related to radiation can contribute to the development of osteoarthritis. Monitor...
Radiation-induced Lung Injury (RILI) in Non-human Primates (NHPs) Induces Cellular Senescence and Upregulation of Tyrosine Kinase Fgr, which is Detectable in Bronchoalveolar Lavage [0.03%]
辐射诱导的非人灵长类动物肺损伤（RILI）引起细胞衰老并上调酪氨酸激酶Fgr，该变化可通过支气管肺泡灌洗液检测到
George W Schaaf,John D Olson,Baher A Elgohari et al.
George W Schaaf et al.
Radiation-induced lung injury (RILI) includes early acute phase radiation pneumonitis (RP), and late chronic phase radiation-induced pulmonary fibrosis (RIPF). There is increasing evidence that ionizing radiation-induced cellular senescence...
Postmortem Findings from the Wake Forest University Radiation Late Effects Cohort of Rhesus Monkeys (Macaca mulatta) [0.03%]
威克森林大学放射线长期影响恒河猴群体的死后发现（猕猴）
George W Schaaf,John D Olson,Brooke T Kahn et al.
George W Schaaf et al.
The Wake Forest Radiation Late Effects Cohort (RLEC), formerly known as the Radiation Survivors Cohort, of rhesus (Macaca mulatta) non-human primates (NHPs) is a unique colony of long-term survivors of total-body irradiation (TBI). The coho...