Differential Radiosensitivity in T-Cell Subsets: Metabolic and Antioxidative Mechanisms Underlying Naïve T-Cell Vulnerability [0.03%]
T细胞亚群的差异放射敏感性：初代T细胞脆弱性的代谢及抗氧化机制研究
Lorreta Yun-Tien Lin,Anika Kot,Albert J Fornace Jr et al.
Lorreta Yun-Tien Lin et al.
T cells, which are generally highly sensitive to DNA damage-induced cell death, exhibit distinct responses to ionizing radiation (IR) depending on their differentiation state. In this study, we investigated the heightened radiosensitivity o...
Enhanced Response to Radiopharmaceutical Therapy in Preclinical Tumor Models with XRD-0394, a Dual Inhibitor of ATM Kinase and DNA-PKcs [0.03%]
一种ATM激酶和DNA-PKcs的双抑制剂XRD-0394可增强放射性药物治疗的疗效：基于肿瘤模型的药理学研究
Caroline P Kerr,Won Jong Jin,Alejandro J Oñate et al.
Caroline P Kerr et al.
Enhanced DNA repair is a common mechanism of radiation resistance. XRD-0394, a novel small molecule dual inhibitor of ataxia telangiectasia mutated (ATM) kinase and deoxyribonucleic acid (DNA)-dependent protein kinase (DNA-PKcs), may sensit...
Transient Oxygen Depletion and FLASH: Are We Ruling It Out Too Soon? [0.03%]
瞬时氧耗竭和FLASH：我们是否过早排除了它们？
George D D Jones,Jan Schuemann,Bethany Rothwell
George D D Jones
The contribution of transient oxygen depletion (TOD) to the FLASH effect has been challenged, primarily because measurements indicate both insufficient depletion rates and normal tissue oxygenation levels that are too high. We argue that th...
Underscoring the Effects of Proton Radiation on Neuronal Function in 2D and 3D In Vitro Cortical Tissue Models [0.03%]
质子辐射对二维和三维皮质组织模型中神经元功能影响的实验研究
Neal M Lojek,Nazli Bostanci,Paulo Henrique Borges et al.
Neal M Lojek et al.
Proton radiation is known to have detrimental neurological effects, but there is limited scientific understanding of these effects at the cellular and tissue levels. We leveraged our 3D in vitro cortical tissue model alongside 2D cortical c...
Characterization of the Sequence of Cytopenia after Total-body Irradiation using Unsupervised Machine Learning [0.03%]
无监督机器学习描述全身照射后的细胞减少序列特征
Rahul K Goyal,John L McManus,Matangi Gopalakrishnan
Rahul K Goyal
Hematopoietic acute radiation syndrome (H-ARS) elicits multidimensional effects, as total-body irradiation (TBI) induced myelosuppression results in distinct patterns of loss and recovery across blood cell lineages. This study aimed to char...
Investigating the Toxicity and Biodistribution of Boron-loaded Liposomes in Canine and Feline Models [0.03%]
载硼脂质体的毒性及生物分布的犬猫模型研究
M Heidari-Kharaji,Peter J Orto,T A Everett et al.
M Heidari-Kharaji et al.
Boron neutron capture therapy (BNCT) is a targeted cancer treatment that relies on the selective accumulation of boron-containing agents in tumor cells, followed by irradiation with low-energy neutrons to produce a cytotoxic reaction. Lipos...
Individualized Dose-volume Reconstruction Workflow for the Normal Tissues of Pediatric Patients Treated with Passive Scattering Proton Therapy [0.03%]
儿科患者受被动散射质子治疗的正常组织个体化剂量体积重建工作流程
Keith T Griffin,Jan Schuemann,Aimee L McNamara et al.
Keith T Griffin et al.
The United States National Cancer Institute has launched a large epidemiological cohort study comparing subsequent cancer risks from photon and proton radiotherapy in pediatric cancer patients. Clinical data, including electronic radiothera...
Low-dose Ionizing Radiation, a Protective Intervention to Mitigate Chronic Cerebral Hypoperfusion-induced Brain Damage and Cognitive Deficits in the Rat [0.03%]
低剂量电离辐射通过改善脑缺血损伤和认知障碍保护慢性脑低灌注的作用及机制研究
Valentin Beaufils,Fatima-Azzahra Dwiri,Julie Bécam et al.
Valentin Beaufils et al.
Vascular dementia is a leading cause of cognitive decline, with few effective treatment options currently available. Within the framework of hormesis, treatment with low-dose ionizing radiation (LDIR
Emerging Roles of Multiparametric Biodosimetry and Artificial Intelligence in Advancing Radiation Dose Assessment for Triage [0.03%]
生物参数 biodosimetry 和人工智能在辐射剂量评估中的新兴作用及未来发展趋势——以分类为例
Adayabalam S Balajee
Adayabalam S Balajee
Biodosimetry plays a crucial role in radiation emergency preparedness and response by enabling efficient allocation of medical resources through prioritization of individuals needing urgent care to improve survival outcomes. Because current...
Neuroprotective Effects of Melatonin on Neurotrophic, Apoptotic/Antiapoptotic and Inflammation Markers in the Rat Cerebrum and Cerebellum after Cranial Radiotherapy [0.03%]
褪黑素对放射性脑损伤大鼠大脑和小脑神经营养、凋亡/抗凋亡及炎症指标的保护作用研究
Fatih Hacımustafaoğlu,Serhat Aras,Yalçın Erzurumlu et al.
Fatih Hacımustafaoğlu et al.
This study aims to investigate the radioprotective effects of melatonin (MEL) against oxidative damage that may be caused by flattening filter (FF) and flattening filter-free (FFF) beam in the cerebrum and cerebellum of rat using various ge...