Proline Intake Dampens Radiosensitivity in Prostate Cancer Cells by Targeting PRODH/MAPK Pathway [0.03%]
脯氨酸通过靶向PRODH / MAPK通路抑制前列腺癌细胞的放射敏感性
Lei Chang,Xinzhou Deng,Shan Jiang et al.
Lei Chang et al.
Radiotherapy remains a standard treatment for prostate cancer (PCa), inducing tumor cell death and apoptosis. However, its efficacy depends on various factors, including tumor cell metabolism. In this study, we investigated whether alterati...
Dose Optimization and Receptor Utilization of Prostaglandin E Analogs for Radioprotection and Radiomitigation of H-ARS and DEARE [0.03%]
前列腺素E类似物的剂量优化和受体利用以对H-ARS和DEARE进行放射防护和放射治疗
Tong Wu,P Artur Plett,Hailin Feng et al.
Tong Wu et al.
The prostaglandin E2 (PGE2) analog 16, 16 dimethyl-PGE2 (dmPGE2) administered prior to lethal irradiation protects against mortality from the hematopoietic acute radiation syndrome (H-ARS) and the chronic delayed effects of acute radiation ...
Serum Proteomic Signatures in Nonhuman Primates after Treatment with a Radiation Countermeasure and Exposure to a Partial- or Total-body Supralethal Radiation Dose [0.03%]
接受辐射防护剂治疗并暴露于半致死剂量或全致死剂量放射后的非人灵长类动物血清蛋白标志物特征分析
Alana D Carpenter,Yaoxiang Li,Jeyalakshmi Kandhavelu et al.
Alana D Carpenter et al.
As countries face emerging conflicts and evaluate military strategies, the potential for nuclear-related accidents continues to rise, putting large populations of civilians at risk. As a result, the development of pharmaceuticals that can b...
Radiosensitization of Cancer Cells by 5-Selenocyanato- and 5-Trifluoromethanesulfonyl- Derivatives of 2'-deoxyuridine [0.03%]
5-硒氰酸盐和5-三氟甲烷磺酰基-2'-脱氧尿苷衍生物的放射增敏作用对抗癌细胞的作用
Magdalena Zdrowowicz,Magdalena Datta,Karol Biernacki et al.
Magdalena Zdrowowicz et al.
Radiation chemical studies together with theoretical calculations have confirmed that 5-selenocyanato-2'-deoxyuridine (SeCNdU) and 5-trifluoromethanesulfonyl-2'-deoxyuridine (OTfdU) undergo dissociation induced by an excess electron attachm...
Spleen Transcriptome of Nonhuman Primates Exposed to High Doses of Total- or Partial-Body Radiation Comparisons with Jejunum and Lung [0.03%]
非人灵长类动物全身或部分身体暴露于高剂量电离辐射后脾脏转录组变化与空肠和肺的比较研究
Neetha Nanoth Vellichirammal,Nagavardhini Avuthu,Stephen Y Wise et al.
Neetha Nanoth Vellichirammal et al.
Total-body irradiation (TBI) and partial-body irradiation (PBI) after a radiological or nuclear event result in acute radiation syndrome. Such radiation-induced injuries require immediate diagnosis and treatment. New strategies are required...
Leukemia, Lymphoma, and Multiple Myeloma Mortality in the Russian Mayak Worker Cohort 1948-2015 [0.03%]
俄罗斯梅雅克工人队列（1948~2015年）中的白血病、淋巴瘤和多发性骨髓瘤死亡率研究
Mikhail E Sokolnikov,Daniel O Stram,Dale L Preston et al.
Mikhail E Sokolnikov et al.
Increased leukemia incidence or mortality is a well-known effect of acute radiation exposure. Less is known about the risks associated with protracted exposure, such as those arising in occupational exposure settings. We used excess relativ...
Regulation of Germ Cell Apoptosis by Innate Immune Pathways in Caenorhabditis elegans Exposed to Ionizing Radiation [0.03%]
秀丽杆线虫感应离子辐射诱导生殖细胞凋亡的先天免疫通路及其调节机制研究
Xiaoman Li,Kangyang Li,Meimei Zhao et al.
Xiaoman Li et al.
Ionizing radiation induces cytokine expression, affecting apoptosis through pro- and anti-apoptotic signals. Although some innate immune pathways regulating radiation-induced germ cell apoptosis have been identified in Caenorhabditis elegan...
Mitigation of Radiation-induced Cardiotoxicity by Subcutaneous "Protective Wounding" [0.03%]
皮下"保护性损伤"对放射性心毒性的缓解作用
Joseph R Dynlacht,Joy Garrett,Meijing Wang et al.
Joseph R Dynlacht et al.
Recent advances in dose-delivery techniques have led to a reduction in normal tissue complications in radiotherapy patients. However, significant early and late cardiovascular (CV) effects may result when the heart is included in the radiat...
A Novel Haploid Cell Culture System for Multi-layered Analysis of Radiation Effects on Human Cells [0.03%]
一种新的单倍体细胞培养体系用于多层次分析辐射对人类细胞的影响
Kasumi Kawamura,Norisato Mitsutake,Keiji Suzuki
Kasumi Kawamura
Ionizing radiation causes various types of DNA damage in mammalian cells, leading to tissue reactions and stochastic effects. Different cultured cell lines have been used to study DNA alterations at the molecular level; however, most previo...
Extracellular DNA-mediated Differential Bystander Effects Induced by FLASH or Conventional Proton Radiation [0.03%]
由FLASH或传统质子辐射诱导的外源性DNA介导的旁观者效应差异
Ying Xu,Zi Guo,Yunan Ding et al.
Ying Xu et al.
A cutting-edge advancement known as FLASH radiotherapy, administered at an ultra-high dose rate of ≥40 Gy/s, has garnered considerable attention for its ability to spare normal tissues while retaining its efficacy in targeting tumors. Howe...