G0/G1 Switch 2 Regulates Radiation Sensitivity of Human Head and Neck Cancer through a G1-lipid Checkpoint [0.03%]
G0/G1转换开关2通过G1脂质检查点调节人类头颈部癌的放射敏感性
Niritta Patel,Amanda L Kalen,Leon Isakov et al.
Niritta Patel et al.
Head and neck squamous cell carcinoma (HNSCC) resistance to radiotherapy has prompted a need to develop adaptive radiation therapy protocols to improve patient outcomes. This study investigates the hypothesis that lipid metabolism regulates...
Effects of Ultra-High Dose-Rate Radiotherapy (FLASH-RT) on the Hematopoietic and Immune Systems: An Animal Study [0.03%]
超高速率放疗(FLASH-RT)对造血系统和免疫系统影响的动物研究
Tosol Yu,Yujeong Yoon,Chul-Won Choi et al.
Tosol Yu et al.
Ultra-high dose-rate radiotherapy, also known as FLASH radiotherapy (FLASH-RT), reduces radiation-induced damage in several organs. This study aimed to compare the effects of FLASH-RT and conventional dose-rate radiotherapy (CONV-RT) at 3 G...
Promoted Misrejoining of X-ray Radiation-induced DNA Double-Strand Breaks in Novel DNA Ligase IV-Deficient Mouse Cells [0.03%]
新型DNA连接酶IV缺陷小鼠细胞中电离辐射诱导的DNA双链断裂受控错误重接的研究
Maiko Kawata,Kazunori Shiraishi,Izumi Satake et al.
Maiko Kawata et al.
DNA double-strand breaks (DSBs) are the most severe type of DNA damage in living organisms and are primarily repaired by two pathways: non-homologous end joining (NHEJ) and homologous recombination (HR). DNA ligase IV (LIG4) is essential fo...
Ferroptosis is a Pivotal Player in Radiation-induced Cell Death of Colorectal Cancer Cells [0.03%]
铁死亡在结直肠癌细胞辐射诱导的细胞死亡中的关键作用
Lisa Kerkhove,Febe Geirnaert,Jana Coppens et al.
Lisa Kerkhove et al.
Ferroptosis, an iron-dependent type of regulated cell death (RCD), has recently been associated with radiation efficacy. However, the impact of ferroptosis inducers (FINs) on colorectal cancer (CRC) cell lines varies tremendously. This stud...
Dynamic Metabolomics Atlas of Radiation-induced Liver Injury and Hepatocyte Proliferation Process in Rat [0.03%]
大鼠辐射性肝损伤及肝细胞增殖过程的动态代谢图谱分析
Qiaoyuan Wu,Liqing Li,Yuxin Wei et al.
Qiaoyuan Wu et al.
This study aims to elucidate the processes involved in radiation-induced liver injury and subsequent hepatocyte proliferation, and to identify novel metabolic profiles associated with progression of liver injury and hepatocyte proliferation...
Dynamic Metabolomics Atlas of Radiation-induced Liver Injury and Hepatocyte Proliferation Process in Rat [0.03%]
大鼠辐射性肝损伤和肝细胞增殖过程的动态代谢图谱研究
Qiaoyuan Wu,Liqing Li,Yuxin Wei et al.
Qiaoyuan Wu et al.
This study aims to elucidate the processes involved in radiation-induced liver injury and subsequent hepatocyte proliferation, and to identify novel metabolic profiles associated with progression of liver injury and hepatocyte proliferation...
Impact of Oxygen on DNA Damage Distribution in 3D Genome and its Correlation to Oxygen Enhancement Ratio after High-LET Irradiation [0.03%]
氧气对高LET辐射下三维基因组DNA损伤分布的影响及其与氧增强比的关系研究
Ankang Hu,Wanyi Zhou,Xiyu Luo et al.
Ankang Hu et al.
The variation of the oxygen enhancement ratio (OER) across linear energy transfer (LET) currently lacks a comprehensive mechanistic interpretation and a mechanistic model. Our earlier research revealed a significant correlation between the ...
Effects of Tanshinone IIA on Calcium Overload and Pyroptosis in Radiation-induced Heart Disease Evaluated in Vivo and in Vitro [0.03%]
基于体内外研究探讨丹参酮 ⅡA 对放射性心脏病钙超载及焦亡的影响
Yan-Ling Li,Gang Wang,Yan-Biao Shu et al.
Yan-Ling Li et al.
Radiation-induced heart disease (RIHD) has become an unavoidable and challenging problem that greatly impacts the outcomes of patients with tumors undergoing radiotherapy. Many studies have shown the positive effects of tanshinone IIA on ca...
Predicting the Effectiveness of Low-Energy Ions, an Extension of the Local Effect Model [0.03%]
低能量离子有效性预测的局地效应模型的拓展研究
K Sennhenn,M Scholz,T Friedrich
K Sennhenn
In the field of radiation physics, understanding the impact of low-energy ions with high-linear energy transfer (LET) is crucial for assessing both radiation protection and particle therapy risks. However, predicting their biological effect...
Exploring Erythrocyte Glycophorin a Somatic Mutations and ERCC5 Genotypes in Atomic Bomb Survivors: An Association Analysis [0.03%]
一次炸弹幸存者红细胞糖基蛋白A体细胞突变与ERCC5基因型的关联分析
Tomonori Hayashi,Kousuke Tanimoto,Naohiro Kato et al.
Tomonori Hayashi et al.
Individual differences in the effects of ionizing radiation on humans remain poorly understood. Although studies on atomic bomb survivors have demonstrated that the hemizygous glycophorin A (GPA) gene mutant fraction (GPA Mf) in erythrocyte...