Brit Salbu
Brit Salbu
When environmental impact and risks associated with radioactive contamination of ecosystems are assessed, the source term and deposition must be linked to ecosystem transfer, biological uptake and effects in exposed organisms. Thus, a well-...
Novel Small Molecule, UTS-1401, as a Radioprotector for Total-Body Irradiation [0.03%]
用于全身辐照的新型小分子放射保护剂UTS-1401
Frederick A Valeriote,Stephen L Brown,Joseph Media et al.
Frederick A Valeriote et al.
We report on a new radioprotector, UTS-1401, a small molecule that was synthesized (by one of us, JS) and evaluated here for its radioprotective effect against total-body irradiation (TBI). Female and male NIH Swiss mice were subjected to T...
Seventy Years of Dose-response Models: From the Target Theory to the Use of Big Databases Involving Cell Survival and DNA Repair [0.03%]
剂量效应模型七十载：从靶理论到大规模数据库在细胞存活和DNA修复中的应用
Larry Bodgi,Laurent Pujo-Menjouet,Audrey Bouchet et al.
Larry Bodgi et al.
Radiobiological data, whether obtained at the clinical, biological or molecular level has significantly contributed to a better description and prediction of the individual dose-response to ionizing radiation and a better estimation of the ...
Mechanism of the Radioresistant Colorectal Cancer Cell Line SW480RR Established after Fractionated X Irradiation [0.03%]
分次X射线照射建立的耐辐射结直肠癌SW480RR细胞系的机制研究
Koya Yamashita,Hironobu Yasui,Tomoki Bo et al.
Koya Yamashita et al.
Radioresistant cancer cells are risk factors for recurrence and are occasionally detected in recurrent tumors after radiotherapy. Intratumor heterogeneity is believed to be a potential cause of treatment resistance. Heterogeneity in DNA con...
A Novel TGFβ Receptor Inhibitor, IPW-5371, Prevents Diet-induced Hepatic Steatosis and Insulin Resistance in Irradiated Mice [0.03%]
新型TGFβ受体抑制剂IPW-5371可预防放射小鼠的饮食诱导性肝脂肪变性和胰岛素抵抗
Alexandria M Szalanczy,Chrissy Sherrill,Katherine M Fanning et al.
Alexandria M Szalanczy et al.
As the number of cancer survivors increases and the risk of accidental radiation exposure rises, there is a pressing need to characterize the delayed effects of radiation exposure and develop medical countermeasures. Radiation has been show...
Revisiting an Inverse Dose-Fractionation Effect of Ionizing Radiation Exposure for Ischemic Heart Disease: Insights from Recent Studies [0.03%]
放射性暴露的逆向剂量分割效应与缺血性心脏病： recent studies带来的新思考
Lydia B Zablotska,Mark P Little,Nobuyuki Hamada
Lydia B Zablotska
Over the last two decades, there has been emerging evidence suggesting that ionizing radiation exposures could be associated with elevated risks of cardiovascular disease (CVD), particularly ischemic heart disease (IHD). Excess CVD risks ha...
Effects of Photon versus Carbon-Ion Irradiation in the Rat Cervical Spinal Cord - a Serial T2 and Diffusion-weighted Magnetic Resonance Imaging Study [0.03%]
光子与碳离子照射对大鼠颈椎脊髓效应的磁共振成像研究
Thomas Welzel,Maria Saager,Peter Peschke et al.
Thomas Welzel et al.
Carbon-ion irradiation is increasingly used at the skull base and spine near the radiation-sensitive spinal cord. To better characterize the in vivo radiation response of the cervical spinal cord, radiogenic changes in the high-dose area we...
Comparative Study
Radiation research. 2024 Jul 1;202(1):11-15. DOI:10.1667/RADE-23-00151.1 2024
Evaluation of Cell Cycle-Dependent Migration Activity after X-ray Exposure: A Radiobiological Approach for Optimization of Radiotherapy with Cell Cycle-Targeting Agents [0.03%]
辐照后细胞周期依赖性迁移活性的评估：一种优化细胞周期靶向剂放射治疗的放射生物学方法
Ryosuke Seino,Hisanori Fukunaga
Ryosuke Seino
Radiotherapy with cell cycle-specific anticancer agents has become an important option in the control of both primary tumors and metastases. Here, we used image analysis algorithms that enable quick segmentation and tracking to describe a r...
Rethinking the Role of Biodosimetry to Assess Risks for Acute Radiation Syndrome in Very Large Radiation Events: Reconsidering Legacy Concepts [0.03%]
重新思考生物剂量学在非常大的辐射事件中评估急性放射病风险的作用：重新考虑传统概念
Harold M Swartz,Ann Barry Flood
Harold M Swartz
The development of effective uses of biodosimetry in large-scale events has been hampered by residual, i.e., "legacy" thinking based on strategies that scale up from biodosimetry in small accidents. Consequently, there remain vestiges of un...