Rapamycin Reduces Carcinogenesis and Enhances Survival in Mice when Administered after Nonlethal Total-Body Irradiation [0.03%]
雷帕霉素可通过非致死全身照射后给药降低致癌性并增强小鼠存活率
Anastasia L Sowers,Sangeeta Gohain,Elijah F Edmondson et al.
Anastasia L Sowers et al.
The rationale of this study stems from the concern of a radiation-induced accident or terrorist-mediated nuclear attack resulting in large populations of people exposed to nonlethal radiation doses or after a course of definitive radiation ...
Dose Reconstruction for Epidemiological Studies among Ukrainian Chernobyl Cleanup Workers [0.03%]
乌克兰切尔诺贝利事故清理工人队列流行病学研究中的剂量重建
Vladimir Drozdovitch,Victor Kryuchkov,Elena Bakhanova et al.
Vladimir Drozdovitch et al.
The present paper provides an overview of the methods and summarizes the results of estimating radiation doses and their uncertainties for Ukrainian-American epidemiological studies among the Chernobyl (Chornobyl) cleanup workers. After the...
The Role of Natural Background Radiation in Maintaining Genomic Stability in the CGL1 Human Hybrid Model System [0.03%]
关于天然背景辐射在维持CGL1人杂交模型系统基因组稳定性中的作用
Jake Pirkkanen,Taylor Laframboise,Jayden Peterson et al.
Jake Pirkkanen et al.
Natural background ionizing radiation is present on the earth's surface; however, the biological role of this chronic low-dose-rate exposure remains unknown. The Researching the Effects of the Presence and Absence of Ionizing Radiation (REP...
Effect of Age at Time of Irradiation, Sex, Genetic Diversity, and Granulopoietic Cytokine Radiomitigation on Lifespan and Lymphoma Development in Murine H-ARS Survivors [0.03%]
照射时的年龄、性别、遗传多样性以及粒细胞生成细胞因子辐射防护对小鼠H-ARS幸存者寿命和淋巴瘤发生的影响
P Artur Plett,Hui Lin Chua,Tong Wu et al.
P Artur Plett et al.
Acute, high-dose radiation exposure results in life-threatening acute radiation syndrome (ARS) and debilitating delayed effects of acute radiation exposure (DEARE). The DEARE are a set of chronic multi-organ illnesses that can result in ear...
Developing an RNA Signature for Radiation Injury Using a Human Liver-on-a-Chip Model [0.03%]
利用人体肝脏芯片模型开发辐射损伤的RNA标志物
Shannon Martello,Yuki Ueda,Michelle A Bylicky et al.
Shannon Martello et al.
Radiation exposure in a therapeutic setting or during a mass casualty event requires improved medical triaging, where the time to delivery and quantity of medical countermeasures are critical to survival. Radiation-induced liver injury (RIL...
Mitigation of Fetal Radiation Injury from Mid-Gestation Total-body Irradiation by Maternal Administration of Mitochondrial-Targeted GS-Nitroxide JP4-039 [0.03%]
母体给予线粒体靶向GS-硝基咪唑JP4-039减轻中孕期全身辐照引起的胎儿损伤
Yijen L Wu,Anthony G Christodoulou,Jan H Beumer et al.
Yijen L Wu et al.
Victims of a radiation terrorist event will include pregnant women and unborn fetuses. Mitochondrial dysfunction and oxidative stress are key pathogenic factors of fetal radiation injury. The goal of this preclinical study is to investigate...
Selecting the Most Relevant Mouse Strains for Evaluating Radiation-Induced Multiple Tissue Injury after Leg-Shielded Partial-Body Gamma Irradiation [0.03%]
评估遮挡部分身体γ射线照射后引起多个组织损伤时选择最相关的实验小鼠品系
Julian D Down,Milton R Cornwall-Brady,Wei Huang et al.
Julian D Down et al.
Animal studies are needed that best simulate a large-scale, inhomogeneous body exposure after a radiological or nuclear incident and that provides a platform for future development of medical countermeasures. A partial-body irradiation (PBI...
Relative Biological Effectiveness of Carbon Ion Beams for Induction of Medulloblastoma with Radiation-specific Chromosome 13 Deletion in Ptch1+/- Mice [0.03%]
碳离子束相对于质子束诱导Ptch1基因杂合突变小鼠发生伴独特的染色体13号单倍体缺失的髓母细胞瘤的相对生物学效应研究
Chizuru Tsuruoka,Mayumi Shinagawa,Yi Shang et al.
Chizuru Tsuruoka et al.
Carbon ion radiotherapy (CIRT) for pediatric cancer is currently limited because of the unknown risk of induction of secondary cancers. Medulloblastoma of Ptch1+/- mice offers a unique experimental system for radiation-induced carcinogenesi...
Angela M Groves,Nicole D Paris,Carl J Johnston et al.
Angela M Groves et al.
Inflammation is a key factor in both influenza and radiation-induced lung pathophysiology. This implies a commonality of response to pulmonary damage from these insults and suggests exacerbated pathology may occur after combined exposure. W...
Impact of Cosmic Rays on Radiation Exposures and Scientific Activities at the Atacama Large Millimeter/Submillimeter Array (ALMA) Sites [0.03%]
宇宙射线对阿塔卡马大型毫米/亚毫米波阵列(ALMA)站辐射暴露和科学活动的影响
Guillaume Hubert,Alain Baudry,Alejandro Saez
Guillaume Hubert
This study delves into the investigation of cosmic-ray radiation exposure levels for workers and their impact on the signal correlation subsystems at the Atacama Large Millimeter/submillimeter Array (ALMA) observatory sites. The analysis pr...