Antioxidant Probucol Reduces Mortality in Mice Exposed to Lethal Doses of Ionizing Radiation [0.03%]
抗氧化剂Probucol可降低致命剂量电离辐射照射小鼠的死亡率
Shunsuke Tanigawa,Ki-Ichiro Kawano,Nobuyuki Hamada et al.
Shunsuke Tanigawa et al.
Radiation has beneficial medical and industrial applications; however, high-dose exposure during accidents can result in severe outcomes, including fatal bone marrow failure. Total-body irradiation (TBI) of 6-10 Gy induces hematopoietic fai...
The Detection of Radiation Effects in the Urine of Rhesus Macaques Using Raman Spectroscopy [0.03%]
用于恒河猴尿液检测辐射效应的拉曼光谱法
Courtney S Moore,Amr Sayed Issa,Lacey Ngo et al.
Courtney S Moore et al.
Exposure to ionizing radiation has been associated with the development of neoplasms in humans and other animals. Detection of both neoplastic growth and effects of radiation with standard laboratory testing (hematology and serum chemistry ...
Characterization of Radiation-responsive Genes and Transcript Variants under Different Radiation Qualities, Doses and Dose Rates [0.03%]
不同辐射品质、剂量和剂量率下辐射响应基因及转录变异的特征分析
Maria Polozova,Lourdes Cruz-Garcia,Shanaz A Ghandhi et al.
Maria Polozova et al.
Rapid molecular biodosimetry may support radiation exposure assessment during mass casualty or mixed-field radiological incidents, but how gene expression responses vary across radiation qualities and dose rates remains incompletely charact...
Methyl Quercetin Inhibits Radiation-induced Senescence and TGF-β1-induced Myofibroblast Differentiation Through Psmad3/TGF-Β Signaling [0.03%]
甲基化芹菜素通过P-Smad3/TGF-Β信号通路抑制辐射诱导的衰老和TGF-β1诱导的肌成纤维细胞分化
Heesu Ahn,Eun Joo Chung,Alya White et al.
Heesu Ahn et al.
Previously, we demonstrated that continuous oral delivery of quercetin attenuated radiation-induced dermal fibrosis in C3H/HeN mice exposed to 35 Gy of ionizing radiation. Quercetin was rapidly metabolized and primarily detected in plasma, ...
Characterization of the Sequence of Cytopenia after Total-body Irradiation using Unsupervised Machine Learning [0.03%]
无监督机器学习表征全身体外照射后的细胞减少顺序
Rahul K Goyal,John L McManus,Mathangi Gopalakrishnan
Rahul K Goyal
Hematopoietic acute radiation syndrome (H-ARS) elicits multidimensional effects, as total-body irradiation (TBI) induced myelosuppression results in distinct patterns of loss and recovery across blood cell lineages. This study aimed to char...
Low-Dose Ionizing Radiation Modulates Translation Efficiency in Human Lung Fibroblasts [0.03%]
低剂量电离辐射通过调节翻译效率影响人肺成纤维细胞生物学行为
Rosette N Tamaddon,Martin Roffe,Antonella Bertucci et al.
Rosette N Tamaddon et al.
Understanding the cellular responses to low-dose ionizing radiation exposure (≤ 0.1 Gy) is essential for developing evidence-based radiation protection policies. Unlike high-dose radiation exposure, which is known to alter gene expression ...
Histological Evaluation of In Vivo Dose Delivery in Respiration-gated Small Animal Radiotherapy [0.03%]
呼吸门控小动物放射治疗的组织学评估
Qiwei Wu,Cheng Zheng,Zihao Liu et al.
Qiwei Wu et al.
Preclinical small-animal radiotherapy is essential for advancing radiobiological research. However, respiratory motion causes significant geometric uncertainty and dose blurring, reducing treatment accuracy. This study aims to develop and v...
Salivary Gene Expression Changes after Total Body Irradiation in Leukemia Patients: Toward Non-invasive Biodosimetry [0.03%]
急性白血病患者全身放疗后的唾液基因表达变化：迈向无创生物剂量学检测
S Fischer,M Kasper,S Stewart et al.
S Fischer et al.
Blood is the standard matrix for gene expression (GE)-based biodosimetry, but less invasive sampling methods are needed in emergency settings and for longitudinal monitoring. Saliva, which contains leukocytes and an ultrafiltrate of blood, ...
Using Gene Expression Changes for Monitoring Glioblastoma WHO CNS Grade 4 Recurrence: Validation of NGS Candidate Genes via qRT-PCR [0.03%]
通过qRT-PCR验证NGS候选基因以实现对IV级胶质母细胞瘤复发进行基因表达变化监测
R Muhtadi,N Schmid,D Bernhardt et al.
R Muhtadi et al.
Glioblastoma WHO CNS Grade 4 (GBM) is associated with poor prognosis and high recurrence rates despite the current therapeutic interventions. Conventional imaging bears restrictions in detecting tumor recurrence and discriminating it from t...
Total-Body Irradiation and Muscular Damage: A New Model of Radiation Combined Injury in Rats [0.03%]
全身照射与肌肉损伤：大鼠放射复合伤的新模型
Chloé Cervera,Laure Bobyk,Marco Valente et al.
Chloé Cervera et al.
The potential use of tactical nuclear weapons or improvised nuclear devices in conflict scenarios could cause mass casualties, exposing victims to both physical trauma and ionizing radiation, resulting in complex injuries related to irradia...