Radiation-induced Brain Injury and the Radiation Late Effects Cohort (RLEC) of Rhesus Macaques (Macaca mulatta) [0.03%]
辐射引起的脑损伤及恒河猴(Rhesus Macaques, Macaca mulatta)的辐射迟发效应群组(RLEC)研究
Brendan J Johnson,Rachel N Andrews,John D Olson et al.
Brendan J Johnson et al.
In the event of a nuclear accident or attack, thousands of people could receive high doses of total-body irradiation (TBI). Although retrospective analyses of atomic bomb and nuclear disaster survivors have been conducted, the long-term out...
Persistent Postirradiation Skeletal Muscle Protein and Insulin Sensitivity Changes in Nonhuman Primates [0.03%]
非人灵长类动物放疗后持续存在的肌肉蛋白和胰岛素敏感性变化
Jingyun Lee,Xiaofei Chen,Katherine M Fanning et al.
Jingyun Lee et al.
Increased incidence of diabetes has been reported after whole-body irradiation in cancer survivors and in the years after exposure in research studies of nonhuman primates. Type 2 diabetes presents in the absence of obesity and suggests tha...
Calculations of Mean Quality Factors and Their Implications for Organ-specific Relative Biological Effectiveness (RBE) in Analysis of Radiation-related Risk in the Atomic Bomb Survivors [0.03%]
用于分析原子 bomb 生存者辐射相关风险的器官特异性相对生物效应（RBE）的平均质量系数计算及其意义
Shota Shimizu,Tatsuhiko Sato,Sachiyo Funamoto et al.
Shota Shimizu et al.
Past and current estimates of relative biological effectiveness (RBE) from the cohort analyses of atomic bomb survivors suggested not only that RBE may be much higher than those assessed by the United Nations Scientific Committee on Effects...
The Long-term Effects of Acute Total-Body Irradiation on Pre-irradiation Measles-vaccine-induced Immunological Memory [0.03%]
急性全身照射对灭活麻疹疫苗接种免疫记忆的长期影响研究
Erica L Stover,Michelle L Rock,John D Olson et al.
Erica L Stover et al.
Acute total-body irradiation (TBI) leads to transient dose-dependent lymphopenia. While lymphocyte numbers gradually recover, there remain subtle but long-lasting changes to B and T cell populations years after radiation exposure. The degre...
PRMT7 Inhibitor SGC3027 Enhances Radiotherapy Efficacy via Activating ATM Kinase in Non-Small Cell Lung Carcinoma [0.03%]
PRMT7抑制剂SGC3027通过激活非小细胞肺癌中的ATM激酶增强放射治疗的疗效
Ya Heng,Feifei Wang,Zhonghui Zhang et al.
Ya Heng et al.
Non-small-cell lung cancer (NSCLC) is the leading cause of tumor-related death in humans. Radiotherapy is a crucial strategy for NSCLC treatment, although its effectiveness is limited by the radio-resistance of tumor cells. Our current rese...
Plasmid DNA Strand Breaks Are Dose Rate Independent at Clinically Relevant Proton Doses and Under Biological Conditions [0.03%]
质粒DNA单链断裂在临界 proton 剂量下以及生物条件下与剂量率无关
Louis V Kunz,Robert Schaefer,Houda Kacem et al.
Louis V Kunz et al.
We investigated the effect of proton FLASH radiation on plasmid DNA. Purified supercoiled pBR322 plasmids were irradiated with clinical doses (≤10 Gy) of protons at ultra-high and conventional dose rates using the Paul Scherrer Institute (...
Systematic Study of Silicon Carbide Detectors and Beam Current Transformer Signals for UHDR Single Electron Pulse Monitoring [0.03%]
用于UHDR单电子脉冲监测的碳化硅探测器及束流电流互感器信号的系统研究
C Okpuwe,G Milluzzo,D Coves et al.
C Okpuwe et al.
The use of ultra-high dose rate beams (UHDR) (> 40 Gy/s) for radiotherapy, despite its advantage of exhibiting the FLASH effect that improves the sparing of healthy tissues, faces challenges in dosimetry and beam monitoring since standard d...
Occupational Exposure to Low Dose Ionizing Radiation and the Incidence of Surgically Removed Cataracts and Glaucoma in a Cohort of Ontario Nuclear Power Plant Workers [0.03%]
低剂量电离辐射职业暴露与安大略省核电站工人队列中经手术去除的白内障和青光眼发病率的关系研究
Paul J Villeneuve,Brianna Frangione,Robert Talarico et al.
Paul J Villeneuve et al.
Ionizing radiation is a human carcinogen and has been shown to increase the risk of non-cancerous ocular disorders. Specifically, findings from epidemiological studies suggest that ionizing radiation leads to the development of cataracts an...
Timosaponin AIII Enhances Radiosensitivity in Breast Cancer through Induction of ROS-Mediated DNA Damage and Apoptosis [0.03%]
Timosaponin AIII通过诱导ROS介导的DNA损伤和凋亡增强乳腺癌放射敏感性
Huiting Peng,Bingqing Cui,Jianming Wei et al.
Huiting Peng et al.
Breast cancer is a commonly diagnosed cancer, while resistance to radiation therapy remains an important factor hindering the treatment of patients. Timosaponin AIII (Tim AIII) is a steroidal saponin from the Anemarrhena asphodeloides. Its ...
Effects of Whole-Body Carbon-Ion Beam Irradiation on Bone Marrow Death in Mice and an Examination of Candidates for Protectors or Mitigators against Carbon-Ion-Beam-Induced Bone Marrow Death [0.03%]
全身影碳离子束照射对小鼠骨髓杀伤作用及防辐剂筛选的初探
Megumi Ueno,Shuichi Setoguchi,Kazuhisa Matsunaga et al.
Megumi Ueno et al.
The present study examined the effects of whole-body carbon-ion-beam irradiation on bone marrow death in mice and investigated whether compounds/materials, which were identified as efficient radio-protectors or mitigators against X-ray-radi...