The Effect of X rays on the Expression of Mismatch Repair Genes and Proteins in Lynch Syndrome Associated Human Colorectal Cancer Cell Lines [0.03%]
X射线对林奇综合征相关人类结直肠癌细胞系错配修复基因和蛋白表达的影响
Mingzhu Sun,Lourdes Cruz-Garcia,Danny Freestone et al.
Mingzhu Sun et al.
This study investigated whether therapeutic X-ray doses can affect the expression of mismatch repair (MMR) genes and proteins using Lynch syndrome-associated human colorectal cancer cell lines. MMR-deficient cell lines (HCT116, SW48, LoVo) ...
Spencer A Witte,Monika Poonia,Mallard Woodward et al.
Spencer A Witte et al.
Hair is an attractive sample for determining exposure to ionizing radiation due to its non-invasive nature. A biological tissue comprised mainly of keratin protein, hair is susceptible to oxidative or reductive stress by direct or indirect ...
Comparative Study of Pathology of Various Organs of Rhesus and Cynomolgus Nonhuman Primates Exposed to Two Different Doses of Acute Total-body Radiation [0.03%]
不同剂量全身照射后食蟹猴和恒河猴主要脏器损伤的病理学比较研究
Vijay K Singh,Stephen Y Wise,Oluseyi O Fatanmi et al.
Vijay K Singh et al.
The rhesus macaque (Macaca mulatta) is the primary nonhuman primate (NHP) model used for the development of radiation medical countermeasures (MCMs), but due to the limited supply of rhesus macaques that has resulted from their need in othe...
A Microdosimetric Dose Response Model for Monoenergetic Ions and Doses Relevant for Space Radiation Carcinogenesis [0.03%]
单能离子和与空间辐射致癌相关的剂量的微剂量响应模型
T C Slaba,F Poignant,S Rahmanian
T C Slaba
The radiation environment in space consists of a complex mixture of particles and energies that are characteristically different from any natural Earth radiation source. Projections of space radiation cancer risk are obtained by scaling or ...
PNA-FISH-based Chromosome Aberration Frequency and Serum IL-6 as Predictive Biomarkers for Radiation Therapy-induced Pneumonitis in Lung Cancer Patients [0.03%]
基于PNA-FISH的染色体异常频率和血清IL-6作为预测肺癌患者放疗引起肺炎标志物的研究
Gloriamaris Loy-Caraos,Nobuki Imano,Ikuno Nishibuchi et al.
Gloriamaris Loy-Caraos et al.
Accurate prediction of symptomatic radiation therapy-induced pneumonitis (RT-IP) remains an important clinical challenge. Currently, mean lung dose and volume of the lungs receiving a 20 Gy threshold of ≤20 Gy and ≤35%, respectively, are ...
Understudied Populations in Radiation Exposure Research: Needs, Challenges, and Mitigation Strategies [0.03%]
辐射暴露研究中被忽视人群的需求、挑战及缓解策略
Lanyn P Taliaferro,Jeffrey C Buchsbaum,Andrea L DiCarlo et al.
Lanyn P Taliaferro et al.
This workshop examined the effects of ionizing radiation on certain understudied populations, including pregnant/lactating, in utero, pediatric, and geriatric populations. Research using animal models has revealed significant age and condit...
Quantifying Sensitivity of Carbon RBE Models to Reference Parameter Variations [0.03%]
碳RBE模型对参考参数变化的敏感性定量
Shannon Hartzell,Fada Guan,Giuseppe Magro et al.
Shannon Hartzell et al.
Models used to calculate the relative biological effectiveness (RBE) of carbon-ion radiotherapy include the microdosimetric kinetic model (MKM), stochastic MKM (SMKM), repair-misrepair-fixation (RMF) model, and local effect model I (LEM). W...
miR-144-3p Regulates the Radiation Sensitivity of Nasopharyngeal Carcinoma Through Targeting the NFE2L2 Pathway [0.03%]
微RNA-144-3P通过靶向NFE2L2通路调节鼻咽癌放射敏感性
Jingjing Chen,Yilong Wang,Na Zhao et al.
Jingjing Chen et al.
Radiation therapy is one of the most critical methods for the comprehensive treatment of nasopharyngeal carcinoma (NPC). However, radiation resistance limits the effectiveness of radiotherapy. MicroRNAs (miRNAs) are associated with the radi...
Radiation Dose and Solid Cancer Mortality Risk in the Techa River and East Urals Radioactive Trace Cohorts in 1950-2016 [0.03%]
1950~2016年捷卡河和乌拉尔放射痕人群队列辐射剂量与实体癌死亡风险关联研究
D L Preston,L Y Krestinina,D O Stram et al.
D L Preston et al.
The objective of the work was to estimate the dose dependence of mortality risk from solid cancers in a cohort that includes members of two cohorts of residents of the Southern Urals who received chronic environmental low-dose, low-dose-rat...