Radiation-induced Lung Injury (RILI) in Non-human Primates (NHPs) Induces Cellular Senescence and Upregulation of Tyrosine Kinase Fgr, which is Detectable in Bronchoalveolar Lavage [0.03%]
辐射诱导的非人灵长类动物肺损伤（RILI）引起细胞衰老并上调酪氨酸激酶Fgr，该变化可通过支气管肺泡灌洗液检测到
George W Schaaf,John D Olson,Baher A Elgohari et al.
George W Schaaf et al.
Radiation-induced lung injury (RILI) includes early acute phase radiation pneumonitis (RP), and late chronic phase radiation-induced pulmonary fibrosis (RIPF). There is increasing evidence that ionizing radiation-induced cellular senescence...
Postmortem Findings from the Wake Forest University Radiation Late Effects Cohort of Rhesus Monkeys (Macaca mulatta) [0.03%]
威克森林大学放射线长期影响恒河猴群体的死后发现（猕猴）
George W Schaaf,John D Olson,Brooke T Kahn et al.
George W Schaaf et al.
The Wake Forest Radiation Late Effects Cohort (RLEC), formerly known as the Radiation Survivors Cohort, of rhesus (Macaca mulatta) non-human primates (NHPs) is a unique colony of long-term survivors of total-body irradiation (TBI). The coho...
John D Olson,George W Schaaf,J Daniel Bourland et al.
John D Olson et al.
Wake Forest University School of Medicine (WFUSM) hosts the Radiation Late Effects Cohort (RLEC), a unique cohort of previously irradiated rhesus monkeys gathered from multiple institutions over twenty years. Supported by the National Insti...
Delayed Effects of Acute Radiation Exposure in the Nonhuman Primate Radiation Late Effects Cohort [0.03%]
非人灵长类动物急性放射照射后远期效应研究群体的长期结果研究报告
J Mark Cline,Polly Chang,Isabel Lauren Jackson et al.
J Mark Cline et al.
Targeting CXCR4 with 212Pb/203Pb-Pentixather Significantly Increases Overall Survival in Small Cell Lung Cancer [0.03%]
使用212Pb/203Pb- Pentixather靶向CXCR4可显著延长小细胞肺癌患者的总生存期
Keegan A Christensen,Melissa A Fath,Jordan T Ewald et al.
Keegan A Christensen et al.
Small cell lung cancer (SCLC) has a 6% 5-year overall survival rate. C-X-C chemokine receptor 4 (CXCR4) is an attractive target for theranostic agents, is highly expressed in SCLCs, and can be targeted with pentixather using the theranostic...
Effects of p53 Mutation on Tumor Radiosensitivity Estimated by Predictive Models [0.03%]
利用预测模型评估p53基因突变对肿瘤放射敏感性的影响
Atsushi Kaida,Hitomi Nojima,Masahiko Miura
Atsushi Kaida
p53 gene mutations are common in various cancers and may provide insights in predicting tumor radiosensitivity. This study aimed to assess the effect of p53 mutations on radiosensitivity using the intrinsic radiosensitivity index (RSI) acro...
Brian Ponnaiya,Naresh T Deoli,Guy Garty et al.
Brian Ponnaiya et al.
Particle radiotherapy is successful in treating cancers that are typically refractory to conventional low-LET therapy; however, the underlying molecular mechanisms remain largely unknown. Some suggest that, in addition to local tumor contro...
A Combat-Relevant Model of Traumatic Hemorrhage in Rats for the Study of Combined Radiation Injury: A Pilot Study [0.03%]
一种用于联合辐射损伤研究的含放射性的大鼠创伤性出血模型的初步研究
Stephanie M Lipiec,Luciana N Torres,Kathy L Ryan et al.
Stephanie M Lipiec et al.
The threat and consequences of nuclear or radiological events remain a military concern today. It is estimated that 65-70% of weapon-related injuries after a nuclear event will be radiation combined injuries, i. e., acute radiation injury a...
Centers for Medical Countermeasures against Radiation Consortium: Past, Present, and Beyond [0.03%]
辐射医疗反措施国家中心联盟：过去、现在和未来方向
Lanyn P Taliaferro,David J Brenner,Sally A Amundson et al.
Lanyn P Taliaferro et al.
The Centers for Medical Countermeasures against Radiation Consortium (CMCRC) has provided a strong research foundation for the radiobiology science that will follow. After 20 years, however, the CMCRC will continue to conduct research on pr...
Immunological and Respiratory Effects in a Healthy Rodent Model after Inhalation of Low and Regulated Levels of Radon [0.03%]
低剂量和恒定氡暴露对健康实验动物的免疫学和呼吸系统影响研究
Dylan De Bellis,James McEvoy-May,Christopher Kalnins et al.
Dylan De Bellis et al.
Radon gas is a naturally occurring substance and contributes significantly to the public background radiation dose. It is widely accepted that radon has harmful effects, being considered the second leading cause of lung cancer after smoking...