Peripheral T Cells as a Biomarker for Oxygen-Ion-Radiation-Induced Social Impairments [0.03%]
外周T细胞作为氧-离子辐射诱导的社会行为障碍生物标志物的可能性
Karen Krukowski,Tamako Jones,Mary Campbell-Beachler et al.
Karen Krukowski et al.
Exposure to galactic cosmic rays (GCR) poses an obstacle to successful deep space missions, including missions to the Moon or Mars. Previously, we and others have identified chronic cognitive impairments associated with GCR in rodent model ...
Brent D Cameron,Konjeti R Sekhar,Maxwell Ofori et al.
Brent D Cameron et al.
The transcription factor Nrf2 is an important modulator of antioxidant and drug metabolism, carbohydrate and lipid metabolism, as well as heme and iron metabolism. Regulation of Nrf2 expression occurs transcriptionally and post-transcriptio...
Postirradiation Necrosis after Slow Microvascular Breakdown in the Adult Rat Spinal Cord is Delayed by Minocycline Treatment [0.03%]
米诺环素治疗延迟成年大鼠脊髓放射性坏死发生时间及机制研究
Karen L Lankford,Edgardo J Arroyo,Jeffery D Kocsis
Karen L Lankford
To better understand the spatiotemporal course of radiation-induced central nervous system (CNS) vascular necrosis and assess the therapeutic potential of approaches for protecting against radiation-induced necrosis, adult female Sprague Da...
Significant Suppression of CT Radiation-Induced DNA Damage in Normal Human Cells by the PrC-210 Radioprotector [0.03%]
放射保护剂PrC-210可显著抑制正常人细胞的CT射线诱导的DNA损伤
Frank Jermusek Jr,Chelsea Benedict,Emma Dreischmeier et al.
Frank Jermusek Jr et al.
While computed tomography (CT) is now commonly used and considered to be clinically valuable, significant DNA double-strand breaks (γ-H2AX foci) in white blood cells from adult and pediatric CT patients have been frequently reported. In th...
Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors [0.03%]
带电铁颗粒可诱导卵巢上皮瘤形成且存在于宇宙射线中
Birendra Mishra,Gregory W Lawson,Ryan Ripperdan et al.
Birendra Mishra et al.
Astronauts traveling in deep space are exposed to high-charge and energy (HZE) particles from galactic cosmic rays. We have previously determined that irradiation of adult female mice with iron HZE particles induces DNA double-strand breaks...
Hypothyroidism after Radiation Therapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study [0.03%]
儿童癌症放射治疗后的甲状腺功能减退症：来自儿童癌症幸存者研究的报道
Peter D Inskip,Lene H S Veiga,Alina V Brenner et al.
Peter D Inskip et al.
While thyroid cancer risks from exposure to ionizing radiation early in life are well characterized quantitatively, the association of radiation with nonmalignant, functional thyroid disorders has been less studied. Here, we report on a ris...
Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells [0.03%]
热激活金属多烯炔的人类黑色素瘤细胞毒性特征研究
Eric J Keller,Meghan Porter,Joy E Garrett et al.
Eric J Keller et al.
Enediynes are a highly cytotoxic class of compounds. However, metallation of these compounds may modulate their activation, and thus their cytotoxicity. We previously demonstrated that cytotoxicity of two different metalloenediynes, includi...
Molecular Cytogenetics Guides Massively Parallel Sequencing of a Radiation-Induced Chromosome Translocation in Human Cells [0.03%]
分子细胞遗传学指导人类辐射诱导染色体重排的大规模平行测序工作
Michael N Cornforth,Pavana Anur,Nicholas Wang et al.
Michael N Cornforth et al.
Chromosome rearrangements are large-scale structural variants that are recognized drivers of oncogenic events in cancers of all types. Cytogenetics allows for their rapid, genome-wide detection, but does not provide gene-level resolution. M...
A Two-Component Assay for Hypoxia Incorporating Long-Term Nitroreduction and Short-Term DNA-Damage Allows Differentiation of the Three Hypoxia Sub-types [0.03%]
一种两部分缺氧分析方法结合长期硝基还原和短期DNA损伤，可区分三种缺氧亚型
Cameron J Koch
Cameron J Koch
Hypoxia in tumors has many well-characterized effects that are known to prevent optimal cancer treatment. Despite the existence of a large number of assays that have supported hypoxia as an important diagnostic, there is no routine clinical...
Gene Expression in Parp1 Deficient Mice Exposed to a Median Lethal Dose of Gamma Rays [0.03%]
帕瑞肽1基因剔除小鼠遭受中剂量γ射线照射的基因表达研究
M A Suresh Kumar,Evagelia C Laiakis,Shanaz A Ghandhi et al.
M A Suresh Kumar et al.
There is a current interest in the development of biodosimetric methods for rapidly assessing radiation exposure in the wake of a large-scale radiological event. This work was initially focused on determining the exposure dose to an individ...