A Novel Haploid Cell Culture System for Multi-layered Analysis of Radiation Effects on Human Cells [0.03%]
一种新的单倍体细胞培养体系用于多层次分析辐射对人类细胞的影响
Kasumi Kawamura,Norisato Mitsutake,Keiji Suzuki
Kasumi Kawamura
Ionizing radiation causes various types of DNA damage in mammalian cells, leading to tissue reactions and stochastic effects. Different cultured cell lines have been used to study DNA alterations at the molecular level; however, most previo...
Extracellular DNA-mediated Differential Bystander Effects Induced by FLASH or Conventional Proton Radiation [0.03%]
由FLASH或传统质子辐射诱导的外源性DNA介导的旁观者效应差异
Ying Xu,Zi Guo,Yunan Ding et al.
Ying Xu et al.
A cutting-edge advancement known as FLASH radiotherapy, administered at an ultra-high dose rate of ≥40 Gy/s, has garnered considerable attention for its ability to spare normal tissues while retaining its efficacy in targeting tumors. Howe...
Genomic Loci of Radiation-induced Lung Disease in a Mouse Model: Refinement and Candidate Gene Analysis [0.03%]
基于小鼠放射性肺损伤模型的易感基因定位及候选基因分析
Ian Johnson,Nicole Ferreira,Vassilena Sharlandjieva et al.
Ian Johnson et al.
Susceptibility to radiation-induced lung disease differs among people and among inbred strains of mice; C3H/HeJ mice develop early onset distress from pneumonitis and C57BL/6J mice present later onset pneumonitis with fibrosis. Previous stu...
Long-term Pathway Activation in Cardiac Ventricular Tissues after Gamma and simGCRsim Irradiation [0.03%]
心脏心室组织的伽马和模拟太阳高能粒子照射后的长期活化效应研究
Gisane Khachatryan,Tamara Sirunyan,Siras Hakobyan et al.
Gisane Khachatryan et al.
Space radiation represents a significant health risk for deep-space exploration, yet its long-term effects on cardiovascular function remain poorly understood. While our previous studies have highlighted persistent transcriptional changes i...
Analysis of the Metabolomic Profile in Serum of Mice Treated with RadioDefender, a Novel Radiation Medical Countermeasure [0.03%]
放射医学对策RadioDefender的小鼠模型的血清代谢组分析
Alana D Carpenter,Matthew W Brink,Xu Li et al.
Alana D Carpenter et al.
Ionizing radiation continues to be weaponized not only through the development of nuclear weapons, but also on a smaller scale through the development of radiological dispersal devices, or dirty bombs. Exposure to acute doses of ionizing ra...
Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice [0.03%]
单次太空相关质子辐射暴露会改变小鼠的肠道一碳代谢途径和微生物群
Isabelle R Miousse,Charles M Skinner,Rupak Pathak et al.
Isabelle R Miousse et al.
Space radiation, primarily originating from galactic cosmic rays, is mainly composed of protons. Given NASA's plans for manned lunar and Mars missions, it is critical to assess the risk of proton radiation in disrupting tissue homeostasis, ...
Cosmic Ray-induced Radiation Exposure among Summer and Overwintering Expeditioners in the High-altitude Antarctic Environment [0.03%]
南极高原夏季和越冬考察队员的宇宙射线辐射暴露量研究
Guillaume Hubert,Eric Lefebvre
Guillaume Hubert
This paper investigates cosmic ray exposure among Antarctic expeditioners through detailed case analyses of individuals undertaking diverse polar missions, encompassing both summer campaigns and extended winter-overs. The first case profile...
Development of Low Radiation Dose Biomarkers: A Commentary on Whether Non-targeted Effects Need to Be Considered [0.03%]
低辐射剂量生物标志物的研发——非目标效应需要被考虑吗？
Carmel Mothersill,Colin Seymour
Carmel Mothersill
The issue of determining likely outcomes after low dose exposure to radiation is complex and controversial. Currently, the linear no-threshold (LNT) model is used to justify the linear extrapolation of (adverse) outcomes from high doses, wh...
Cancer Mortality after Protracted Low-level Radiation Exposure for Early and Contemporary Workers in Two Large Occupational Cohorts in the U.S. Million Person Study [0.03%]
美国百万人研究中两大型职业队列早期和当代工作人员长期低剂量辐射暴露后的癌症死亡率研究
Linda Walsh,Sarah S Cohen,Lawrence T Dauer et al.
Linda Walsh et al.
An evaluation is presented of differences in radiation-related solid cancer mortality risk for early versus contemporary sub-groups of radiation workers in both of the two constituent Million Person Study (MPS) cohorts. The two previously a...
High-dose Radiation Induces an Early and Transient, ATM-dependent Inflammatory Response in Primary Human Endothelial Cells [0.03%]
高强度电离辐射通过ATM依赖性机制诱导人脐静脉内皮细胞早期短暂的炎症反应
Clément Rouichi,Elizabeth Chartier-Garcia,Jean-Luc Ravanat et al.
Clément Rouichi et al.
Inflammation is the initial immune response activated to protect an organism's integrity after cell or tissue damage caused by infectious agents or physical trauma, such as exposure to ionizing radiation. The mechanisms behind ionizing radi...