The EGFR Pathway as a Potential Therapeutic Target for Modulation of Radiation-induced Liver Injury [0.03%]
表皮生长因子受体通路可能的治疗作用靶点调节放射引起的肝损伤
Satoshi Omiya,Juan Dalo,Yuki Ueda et al.
Satoshi Omiya et al.
Radiation exposure can result in various complications influenced by factors such as dose, the amount of tissue exposed, and the type of tissue exposed. Radiation-induced liver injury (RILI) is a concern in cancer patients receiving thoraci...
A Combined Therapy of Pegylated G-CSF with Ciprofloxacin Mitigates Damage Induced by Lethal Ionizing Radiation to the Bone Marrow, Spleen, and Ileum by Increasing AKT Activation but Decreasing IL-18, C3, and miR-34a [0.03%]
聚乙二醇化G-CSF与环丙沙星联合疗法通过增加AKT活化但减少IL-18、C3和miR-34a来减轻致死性电离辐射对骨髓、脾脏和回肠的损伤
Juliann G Kiang,Georgetta Cannon,Min Zhai et al.
Juliann G Kiang et al.
Ciprofloxacin (CIP) was found to enhance pegylated G-CSF therapy (PEG, Neulasta®)-induced survival from 30% to 85% after ionizing radiation exposure. This combined therapy significantly mitigated radiation-induced brain hemorrhage through ...
Symbolic Regression: A Versatile Approach for Constructing Phenomenological Models of Radiobiological Effects [0.03%]
符号回归：构建放射生物学效应现象模型的通用方法
Ankang Hu,Wanyi Zhou,Rui Qiu et al.
Ankang Hu et al.
The development of quantitative models that correlate physical, chemical, and biological parameters with radiobiological effects is imperative in the domains of radiotherapy and radiation protection. Due to the challenges associated with qu...
Mechanisms of Radiation-induced Brain Injury in Mice Based on Bioinformatics Analysis [0.03%]
基于生物信息学分析的小鼠辐射诱发脑损伤机制
Peiquan Liu,Min Fu,Dong Liu et al.
Peiquan Liu et al.
Radiation therapy is a crucial adjunct treatment for head and neck tumors, as well as primary or metastatic brain tumors. Radiation-induced brain injury is one of the most severe complications, postirradiation, in patients with head and nec...
Synthesis and Evaluation of Novel 18F-labeled Oxadiazole-based Positron Emission Tomography Tracers for β-Amyloid [0.03%]
新型18F标记的噁二唑正电子发射断层扫描示踪剂的合成及评估，用于β-淀粉样蛋白成像
Zhongyuan Qi,Wantong Guo,Mengchao Cui et al.
Zhongyuan Qi et al.
This research details the synthesis, structure-activity evaluation, and analysis of novel oxadiazole-based compounds for visualizing β-amyloid (Aβ) in Alzheimer's disease (AD). The derivatives exhibited binding affinities to Aβ aggregate...
Lethality Assessments for Acutely Irradiated Cynomolgus Macaques Under Subject-based Care [0.03%]
基于个体护理的急性照射食蟹猴的致死性评估
Issa Melendez-Miranda,Oluseyi O Fatanmi,Stephen Y Wise et al.
Issa Melendez-Miranda et al.
Well-characterized animal models of acute radiation syndrome are needed for the development of radiation medical countermeasures to mitigate injury due to acute exposure to high doses of total- or partial-body radiation. Such animal models ...
Preparations for Ultra-High Dose Rate 25-90 MeV Electron Radiation Experiments with a Compact, High-Peak-Current, X-band Linear Accelerator [0.03%]
使用紧凑、高峰值电流X波段线性加速器进行超高速率25-90兆电子伏特电子辐射实验的准备
Haytham H Effarah,Trevor Reutershan,Michael W L Seggebruch et al.
Haytham H Effarah et al.
The Distributed Charge Compton Source (DCCS) developed by Lumitron Technologies, Inc. has produced a 25-MeV electron beam with 1.7-nC macrobunches at a 100-Hz repetition rate from a compact, high-gradient X-band (11.424 GHz) accelerator. Th...
What's in a Proton FLASH Beam? Characterizing Ultra-High Dose Rate Protons Using a Commercial Plastic Scintillator [0.03%]
质子束中有什么？使用商用塑料闪烁体表征超高剂量率的质子
Yannick Poirier,Kevin E Byrne,Gulakhshan Hamad et al.
Yannick Poirier et al.
While biological studies of the FLASH effect in proton beams have mainly been performed in the plateau region at maximum beam energy and current, this type of delivery has limited clinical applications. Naturally, it is anticipated that pla...
Widespread Multimorbidity in a Cohort of Aging, Radiation-exposed Rhesus Macaques [0.03%]
老年辐射暴露恒河猴群体中普遍存在多种疾病并发现象
Ellen E Quillen,George W Schaaf,Jamie N Justice et al.
Ellen E Quillen et al.
Delayed effects of acute radiation exposure (DEARE) and radiation late effects are a suite of conditions that become apparent months to years after initial exposure to radiation in both humans and non-human primates. Many of these disorders...
Radiation-induced Brain Injury and the Radiation Late Effects Cohort (RLEC) of Rhesus Macaques (Macaca mulatta) [0.03%]
辐射引起的脑损伤及恒河猴(Rhesus Macaques, Macaca mulatta)的辐射迟发效应群组(RLEC)研究
Brendan J Johnson,Rachel N Andrews,John D Olson et al.
Brendan J Johnson et al.
In the event of a nuclear accident or attack, thousands of people could receive high doses of total-body irradiation (TBI). Although retrospective analyses of atomic bomb and nuclear disaster survivors have been conducted, the long-term out...