Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from old hosts against antibody-opsonized Streptococcus pneumoniae [0.03%]
老年宿主中ERK1/2基线活化削弱了中性粒细胞对抗体包被的肺炎链球菌的抗菌作用
Shaunna R Simmons,Annabel Rivera,Elsa N Bou Ghanem
Shaunna R Simmons
Age-related decline in neutrophil function reduces vaccine protection against Streptococcus pneumoniae. In vaccinated hosts, neutrophil activation via complement and Fcγ receptors mediates bacterial uptake and killing. Mechanisms behind ag...
Sirtuin 1 is an endogenous NETosis inhibitor that becomes dysfunctional in diabetes [0.03%]
沉默信息调节因子1是内源性NETosis抑制因子，糖尿病会导致其功能失调
Liang De Wang,Feng Chen,Rinkoo Dalan et al.
Liang De Wang et al.
Neutrophils release their chromatin with toxic granular proteins as neutrophil extracellular traps (NETs) when activated. Diabetes exacerbates NET formation (NETosis), resulting in tissue damage and diabetic complications such as non-healin...
ICAM-1 and vascular matrices coordinate skin S1-macrophage formation from blood PDGFRα-lineage monocyte [0.03%]
血管细胞黏附分子-1和基质协调血液来源的PDGFRα单核细胞形成皮肤S1型巨噬细胞
Yu-Tung Li,Akito Inoue,Aoi Fukuda et al.
Yu-Tung Li et al.
Extravasation control of leukocytes and their functional fates are crucial to maintain tissue homeostasis. Leukocyte lineage origin regulates these processes that blood monocytes derived from PDGFRα+ embryonic progenitors (PDGFRα-lineage)...
A conserved upstream element in the mouse Csf1r locus contributes to transcription in hematopoietic and trophoblast cells [0.03%]
小鼠Csf1r基因组中一个保守的上游元件可影响造血细胞和滋养层细胞中的转录水平
Emma Maxwell,Isis Taylor,Cameron Flegg et al.
Emma Maxwell et al.
Expression of the Csf1r gene in mice is restricted to cells of the mononuclear phagocyte system and placental trophoblasts. A conserved element (Csf1r upstream regulatory element A, CUREA) in the mouse Csf1r locus contains transcription sta...
Immunity at the edge: Cell-intrinsic roles for intestinal epithelial cells in host immunity [0.03%]
边缘的免疫作用：肠上皮细胞在宿主免疫中的固有细胞功能
Thomas Charron,Ines Hrichi,Ryan D Pardy
Thomas Charron
As the barrier between the contents of the intestines and the rest of the body, intestinal epithelial cells (IEC) occupy a crucial niche for the health of the organism. They are responsible for nutrient absorption and transfer, barrier main...
Eosinophils: Pathological Mechanisms and Novel Targeted Therapeutic Strategies Across Multiple Disease Spectrums [0.03%]
嗜酸性粒细胞：病理机制及多病谱的新型靶向治疗策略
Yuan Chen,Yuhua Liu
Yuan Chen
Eosinophils are a type of white blood cell belonging to the granulocyte family. Their cytoplasm contains eosinophilic granules that hold various biologically active substances. They perform diverse functions, participating in inflammatory r...
Biodegradable microparticles promote anti-inflammatory innate immune memory though a size- and mTOR dependent process [0.03%]
可降解微粒通过尺寸和mTOR依赖型过程促进具有抗炎作用的先天性免疫记忆
Roisin I Lynch,Aoife L Gorman,Sean McCluskey et al.
Roisin I Lynch et al.
Emerging evidence demonstrates that innate immune cells can maintain a non-specific memory, not only in response to microbe-associated ligands such as β-glucan, but also synthetic biomaterials and nano- and microparticles. This creates an ...
Association between absolute blood eosinophil count and carotid plaque in the Multi-Ethnic Study of Atherosclerosis (MESA) [0.03%]
基于多民族动脉粥样硬化研究(MESA)的外周血绝对嗜酸性粒细胞计数与颈动脉斑块的关系
Nyla E Mathis,Mats W Johansson,Spencer L Hansen et al.
Nyla E Mathis et al.
Prior studies have demonstrated associations between eosinophil activation products and incident stroke. We investigated whether circulating eosinophil concentration is associated with imaging markers of atherosclerotic cardiovascular disea...
The selective estrogen receptor modulator bazedoxifene affects the metabolism and functions of human neutrophils [0.03%]
选择性雌激素受体调节剂巴唑昔芬影响人中性粒细胞的代谢和功能
Elena Lonina,Florence Léveillé,Pier-Olivier Leblanc et al.
Elena Lonina et al.
Bazedoxifene is a selective estrogen receptor modulator that is prescribed to menopausal women to treat symptoms of estrogen deficiency. Furthermore, bazedoxifene is being considered for cancer therapeutics due to its ability to block IL-6 ...
CD101 - a versatile molecule associated with immunoregulatory and anti-microbial functions [0.03%]
CD101与免疫调节和抗微生物功能相关的一个多功能分子
Jochen Mattner
Jochen Mattner
CD101 is a disulfide-linked immunoglobulin-like glycoprotein with a unique glutamine-tryptophan-isoleucine (EWI) sequence motif. Allelic variations within the Cd101 gene can influence CD101 expression and function of different myeloid cell ...