Neutrophils and the NLRP3 inflammasome: a tale of proteases, kinases, and inflammation [0.03%]
中性粒细胞和NLRP3炎性小体：关于蛋白酶、激酶和炎症的故事
Vinicius N C Leal,Alexander N R Weber
Vinicius N C Leal
Neutrophils are key first responders to both infectious and noninfectious stress, playing a pivotal role in maintaining homeostasis through tightly regulated activation states and the release of inflammatory mediators. The Nod-like receptor...
Correction to: Hypoxia-activated cystathionine β-synthase/H2S signaling drives drug resistance in acute myeloid leukemia through CD36-mediated fatty acid metabolism [0.03%]
急性髓系白血病中低氧激活的胱硫醚β合成酶/氢硫酸盐信号通过CD36介导的脂肪酸代谢驱动药物耐药性的研究校正案
Published Erratum
Journal of leukocyte biology. 2026 Feb 9;118(2):qiag013. DOI:10.1093/jleuko/qiag013 2026
Interferon stimulation and NKG2D expression drive enhanced natural killer cell antibody-dependent cellular cytotoxicity against viral infections [0.03%]
干扰素刺激和NKG2D表达驱动自然杀伤细胞的抗体依赖性细胞毒性增强以对抗病毒感染
Leslie Chan,Kassandra Pinedo,Samuel Yang et al.
Leslie Chan et al.
Natural killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC) contributes to effective antiviral immunity, yet the relative contribution of NK cell-intrinsic factors and antibodies in mediating these responses remain poorly under...
Neutrophil progenitor cell therapy rescues host defense against Staphylococcus aureus in murine chronic granulomatous disease [0.03%]
中性粒细胞祖细胞治疗可救治小鼠慢性颗粒白血病中的金黄色葡萄球菌感染宿主防御功能障碍问题
Kristina D Hinman,Jason T Machan,Craig T Lefort
Kristina D Hinman
Despite advances in engineered adaptive immune cell therapies, current options for innate immune cell therapies are sparse. In this work, we demonstrate the utility of a neutrophil progenitor-based cell therapy. Murine conditionally-immorta...
Leukocyte immunoglobulin-like receptor subfamily B member 1 expression defines CD8+ T cell exhaustion in acute myeloid leukemia [0.03%]
急性髓系白血病中CD8+T细胞耗竭定义了 leukocyte免疫球蛋白样受体亚家族B成员1的表达
Yuran Miao,Liwan Lin,Zhixi Chen et al.
Yuran Miao et al.
Acute myeloid leukemia (AML) is characterized by profound immune dysregulation, yet the mechanisms underlying impaired cytotoxicity remain unclear. By analyzing samples from 20 AML patients and 20 healthy donors, we integrated scRNA-seq (GS...
Non-eosinophilic leukolectin-proteins occur in cytoplasmic granules in some human leukocytes [0.03%]
非嗜酸性粒细胞白细胞中的蛋白出现在人类某些白细胞的胞浆颗粒中
Mirushe H Miftari,Bernt T Walther
Mirushe H Miftari
Novel leukolectin-proteins (LL-proteins) are present in multiple lower vertebrates. LL-proteins (∼255 AAs) possess five TECPR-domains spanning 4/5 of conserved AA-sequences, and are detected in dermal lectocytes, (primitive and tissue resi...
Christy H Clutter,Daniel T Leung
Christy H Clutter
Mucosal associated invariant T (MAIT) cells are part of a T cell subset that is activated upon presentation of B2 vitamin (riboflavin) metabolites by the major histocompatibility complex, class I related (MR1) protein. Though there is a cle...
Holly Linley,Shafqat Jaigirdar,Lucy Buckingham et al.
Holly Linley et al.
γδ T cells are enriched at barrier sites such as skin, gut and lung, where they protect against cancer and infections, and promote healing. They detect diverse ligands in T cell receptor-dependent or independent manners, producing large q...
Countering tumor-derived PGE2-EP2/4 signaling mediates neutrophil activation [0.03%]
对抗肿瘤源性PGE2-EＰ２／４信号转导可介导中性粒细胞活化
Johanna Bödder,Robbin Kramer,Julia Minnee et al.
Johanna Bödder et al.
Neutrophils have recently been demonstrated to play a variable role in cancer progression, likely due to adaptability to environmental signals that influence neutrophil phenotype and function. In the tumor microenvironment, tumor-derived pr...
EpCAM (CD326) is dispensable for in vitro B cell activation and maintenance of antibody-secreting cells [0.03%]
EpCAM(CD326)对于体外B细胞活化和分泌抗体的细胞维持是不需要的
Shannon R Menzel,Edith Roth,Katharina Pracht et al.
Shannon R Menzel et al.
Antibody-secreting cells (ASCs) provide the foundation for protective humoral immunity following infection or vaccination. Recent advances have revealed substantial phenotypic complexity within the ASC compartment, associated with diverse f...