CD177 Promotes NLR Inflammasome Activation in Acute Respiratory Distress Syndrome by Remodeling Neutrophil Glycolytic Metabolism [0.03%]
CD177通过重塑中性粒细胞糖酵解代谢促进急性呼吸窘迫综合征中NLR炎症小体的激活
Dongfeng Shen,Yuejiao Sun,Yixin Xu et al.
Dongfeng Shen et al.
Acute respiratory distress syndrome (ARDS) is a high-mortality lung disorder driven by excessive neutrophil activation. While neutrophils are central to ARDS, the metabolic pathways fueling their inflammatory response remain unclear. This s...
Macrophage and fibro-adipogenic progenitor (FAP) communication in skeletal muscle regeneration: Tissue homeostasis and pathogenic remodeling [0.03%]
肌营养不良中的巨噬细胞与成脂成纤维前体细胞（FAP）相互作用：从正常骨骼肌再生到病理性肌肉修复和重建的作用机制及功能探讨
Seily Shrestha,Abbey Politeski,Sarah A Dick
Seily Shrestha
Skeletal muscle regeneration depends on coordinated interactions between macrophages, fibro-adipogenic progenitors (FAPs), and muscle stem cells (MuSCs). Following injury, macrophages transition from pro-inflammatory to anti-inflammatory ph...
Yuzhen Ouyang,Mengchuan Luo,Kailin Li et al.
Yuzhen Ouyang et al.
Exhausted T cells (Tex), characterized by impaired cytotoxic function, play a detrimental role in anti-tumor and anti-infection immunity but represent promising therapeutic targets for autoimmune diseases. Persistent exposure to auto-antige...
Macrophage heterogeneity influences cellular response to HIV infection and latency modulation [0.03%]
巨噬细胞异质性影响HIV感染及潜伏期的调节
Michelle E Wong,Laura Rikard-Bell,Salimeh Ebrahimnezhaddarzi et al.
Michelle E Wong et al.
HIV reservoirs persist in macrophages in people with HIV despite antiretroviral therapy, representing a barrier to cure. Factors which govern the establishment and reversal of HIV latency in different macrophage types remain poorly understo...
Kristina Handler,Alessandra Gurtner,Deeksha Raju et al.
Kristina Handler et al.
Eosinophils are challenging to profile by single cell RNA sequencing (scRNA-seq) approaches due to their fragile nature and the abundance of RNases and cytotoxic enzymes stored in cytoplasmic granules, which can compromise RNA integrity upo...
Neutrophil FcγRI expression as a determinant of oxidative responses in human blood [0.03%]
人血中调节氧化应答的中性粒细胞FcγRI表达量测定
Sandrine Huot,Paul R Fortin,Cynthia Laflamme et al.
Sandrine Huot et al.
Neutrophils express Fc receptors on their surface to trap immune complexes. While the roles of FcγRIIa and FcγRIIIb have been extensively studied in that context, that of FcγRI remains elusive. Recently, aggregated IgGs have been shown t...
Tissue Context as a Determinant of Trained Innate Immunity: A Conserved Molecular Toolkit with Divergent Functional Outputs [0.03%]
组织微环境决定先天免疫细胞获得性记忆的形成：保守的分子机制与多样的功能效应
Mary A Oliver,Xenia D Davis,Julia K Bohannon
Mary A Oliver
Trained innate immunity (TI) challenges the traditional view that adaptive immune cells are solely responsible for establishing immune memory. Instead, innate immune cells can develop a form of memory through persistent epigenetic, metaboli...
CCDC137 stabilizes S100A6 to activate the PI3K/AKT pathway and drive acute myeloid leukemia progression [0.03%]
CCDC137通过稳定S100A6来激活PI3K / AKT途径并驱动急性髓系白血病进展
Xiaoying Zhao,Wenjing Zhang,Sirui Chen et al.
Xiaoying Zhao et al.
Coiled-coil domain-containing proteins (CCDCs) play pivotal roles in tumorigenesis by regulating gene transcription, apoptosis, and cell cycle progression. This study focuses on the function and mechanisms of CCDC137 in acute myeloid leukem...
Intrinsic differences in hamster and mouse macrophage biology correlate with susceptibility to Leishmania donovani infection [0.03%]
固有差异仓鼠和小鼠巨噬细胞生物学与利什曼原DONOVANI菌感染的相关性
Paul Jenkins,Anne Danckaert,Thomas Cokelaer et al.
Paul Jenkins et al.
The basis for differential susceptibility to Leishmania donovani infection observed in individuals remains poorly understood. Here we address this important open question comparing bone marrow-derived macrophages (BMDMs) from susceptible ha...
Re-defining granulomas: bacterial effectors, host circuits, and spatially resolved immunity [0.03%]
重塑肉芽肿：细菌效应物、宿主回路和空间免疫分辨率
Daniel S C Butler
Daniel S C Butler
Granulomas are organized immune aggregates of myeloid and lymphoid cells that arise when the host fails to eliminate persistent stimuli; however, their function remains paradoxical, by promoting both protection from systemic dissemination w...