Clotilde Marie Lacroix,Kalyani Kulkarni,Nicola Laura Diny
Clotilde Marie Lacroix
Eosinophils are increasingly recognized as tissue-resident immune cells that take on diverse functions. Recent studies have shed light on the pathways that result in tissue-specific eosinophil phenotypes. In this review, we discuss the proc...
Factor H-Related Protein 1 Deficiency and Risk of Severe Falciparum Malaria in Ghanaian Children: A Cohort Analysis [0.03%]
GHAMA研究中儿童血红素丝氨酸蛋白1缺乏与严重疟疾风险关系的队列分析
Alliyah Uhmon Byrd,Lucy Wahler,Thorsten Thye et al.
Alliyah Uhmon Byrd et al.
Malaria caused by Plasmodium falciparum remains a leading cause of childhood mortality in sub-Saharan Africa. The intraerythrocytic parasite can evade complement-mediated destruction through recruitment of human Factor H (FH). In vitro, Fac...
Gut-derived, inflammatory ILC2s disseminate type 2 immunity to remote lung in food allergen-challenged mice [0.03%]
肠道来源的炎症ILC2s使食物过敏小鼠远端肺组织发生2型免疫反应
Natalie A Falta,Leigha D Larsen,Kriti Gupta et al.
Natalie A Falta et al.
Dissemination of type 2 immunity along skin-gut-lung axes contributes to allergic march progressions in atopic individuals, yet the underlying mechanisms remain incompletely understood. In mice, gastrointestinal helminth infections can mobi...
Three-dimensional modeling of sensory nerve architecture and eosinophil and mast cell interactions in eosinophilic gastrointestinal disease [0.03%]
eosinophilic胃肠疾病的感觉神经结构及嗜酸性粒细胞和肥大细胞相互作用的三维建模
Ari M Levine,Megan Koch,Julius Herzog et al.
Ari M Levine et al.
Increased sensory nerve density has been described in type II inflammatory conditions and is linked to eosinophil and mast cell infiltration and neuropathic pain. To examine these relationships in eosinophilic gastrointestinal diseases (EGI...
Streptococcus anginosus Activates the NLRP3 Inflammasome to Promote Inflammatory Responses from Macrophages [0.03%]
链球菌激活NLRP3炎性小体促进巨噬细胞的炎症反应
Anika M Arias,Dakota M Reinartz,Chloe Sairs et al.
Anika M Arias et al.
Chronic inflammation and oral dysbiosis are common features of oral squamous cell carcinoma (OSCC). The commensal streptococci, S. anginosus, is increased in oral diseases including OSCC. Our previous work revealed that S. anginosus promote...
Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung [0.03%]
趋化因子受体表达定义了从单核细胞到肺成熟巨噬细胞的发育轨迹
Heather Mathie,Laura Medina-Ruiz,Fabian Schuette et al.
Heather Mathie et al.
CCR1, CCR2 and CCR5 direct recruitment of monocytes and macrophages in inflammation. However, the discrete role for each receptor in monocyte/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. Us...
Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil [0.03%]
巴西康复者的HLA-A*2等位基因人群新冠病毒特异性CD8+t细胞免疫图谱：核蛋白为主要抗病毒免疫反应靶标
Ágata Lopes-Ribeiro,Geovane Marques-Ferreira,Franklin Pereira Araujo et al.
Ágata Lopes-Ribeiro et al.
Despite advanced knowledge on the SARS-CoV-2-induced immunity, a deeper understanding of how virus-specific responses are assembled upon infection is necessary. Therefore, the present work investigates the MHC-restricted virus-specific resp...
BET inhibition curbs macrophage inflammation, lipid accumulation, and atherogenesis by disrupting the YAP/TAZ-BRD4 axis [0.03%]
BET抑制通过破坏YAP/TAZ-BRD4轴来减轻巨噬细胞炎症、脂质积累和动脉粥样硬化形成
Praveen Krishna Veerasubramanian,Vijaykumar S Meli,Hamza Atcha et al.
Praveen Krishna Veerasubramanian et al.
Macrophage dysfunction is hallmark of atherosclerotic disease, characterized by inflammation and uptake of oxidized low-density lipoproteins (oxLDL). We investigate the role of the epigenetic reader bromodomain-containing protein 4 (BRD4) i...
Mapping the sepsis immune landscape across age and source of infection: lessons from single-cell multi-omics [0.03%]
脓毒症免疫图谱的跨年龄段和感染来源绘制：单细胞多组学的启示
Mihir R Atreya,Basilia Zingarelli
Mihir R Atreya