Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages [0.03%]
纯合激酶死Csfr1突变的杂种小鼠揭示了组织驻留巨噬细胞的特异和冗余功能
Sebastien Jacquelin,Emma Maxwell,Isis Taylor et al.
Sebastien Jacquelin et al.
The proliferation, differentiation and survival of cells of the macrophage lineage depends on signals from the macrophage colony-stimulating factor receptor (CSF1R). On a C57BL/6J background homozygous kinase-dead Csf1r mutation (Csf1rE631K...
Carboxylesterase 1 contributes to the human macrophage alternative activation response to Th2 cytokine interleukin-4 [0.03%]
羧酸酯酶1对Th2细胞因子白细胞介素4活化的人巨噬细胞的替代激活反应有贡献作用
Matthew K Ross,Abdolsamad Borazjani,Hannah L Thrash et al.
Matthew K Ross et al.
Carboxylesterase 1 (CES1) is a hydrolytic enzyme with roles in xenobiotic and lipid metabolism. Our previous studies suggested a novel role for CES1 in the regulation of macrophage gene expression following exposure to inflammatory molecule...
Sombrero vesicles: from overlooked structures to primary mediators of eosinophil secretion [0.03%]
漏斗状小体：从被忽视的结构到主要嗜酸性粒细胞分泌介导物
Rossana C N Melo,Peter F Weller
Rossana C N Melo
Eosinophils, cells of the innate immune system, have a unique architecture, which includes morphologically complex secretory granules and a prominent, activation-responsive vesiculotubular system. In human eosinophils, this system is collec...
SIV infection induces aging-like alterations in cardiac cellularity and macrophage populations of rhesus macaques [0.03%]
猴免疫缺陷病毒诱导了食蟹猴心脏细胞和巨噬细胞群体的老化表型变化
Daniel I Petkov,Summer Siddiqui,David X Liu et al.
Daniel I Petkov et al.
People living with HIV experience an earlier risk for onset of aging-related chronic inflammatory comorbidities including cardiovascular disease. We previously showed that the proportion of macrophages was higher in the heart of older rhesu...
Glucocorticoid-driven gene expression in circulating monocytes and neutrophils in health and severe inflammation [0.03%]
健康状态和严重炎症外周血单核细胞和中性粒细胞的糖皮质激素驱动基因表达模式及其临床意义
Arthur Molendijk,Leo Koenderman
Arthur Molendijk
Glucocorticoids (GCs) are used as anti-inflammatory and immunosuppressive drugs in many immune mediated diseases, but their use in sepsis and shock is controversial. This is caused in part by a lack of information regarding the responding c...
Raúl F Reyes-Huerta,Rosa G Rebollar-Vega,Jiram Torres-Ruiz et al.
Raúl F Reyes-Huerta et al.
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by skeletal muscle inflammation and systemic immune activation. Although traditionally viewed as T cell-driven diseases, recent evidenc...
Beyond Suppression: The Plasticity, Dysfunction, and Therapeutic Reprogramming of Regulatory T Cells in Inflammatory Bowel Disease [0.03%]
调控性T细胞的可塑性、功能障碍及炎症性肠病中的治疗再编程
Yunting Shao,Shaochen Yu,Mengjie Zhang et al.
Yunting Shao et al.
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gut, whose pathogenesis is closely related to immune dysregulation. Regulatory T cells (Tregs), as a key cell population maintaining intestinal immune tole...
Withania somnifera extracts and withaferin A differentially regulate neutrophil pyroptosis, NETosis, and apoptosis [0.03%]
Withania somnifera提取物和withaferin A差异调节中性粒细胞焦亡、NETosis和凋亡
Partha Sarathi Mondal,Apurwa Singhal,Ritvik Guru et al.
Partha Sarathi Mondal et al.
Neutrophils are short-lived, yet critical components of the innate immune system. These cells play crucial roles in host defense and inflammation. Their high turnover during inflammatory responses is often accompanied by inflammatory lytic ...
Priya Hegde,Clayton Sandel,Alexander Schmidt et al.
Priya Hegde et al.
Sarcoidosis (SRS) is a multi-organ granulomatous disorder that predominantly affects the eyes, lungs, and skin. Biopsy, the standard for a definitive SRS diagnosis, is often impractical for ocular sarcoidosis (OSRS) due to the delicate natu...
Hesham Mohei,Donn A Van Deren,Malay Haldar
Hesham Mohei
Macrophages are highly heterogeneous innate immune cells that populate virtually all tissues, in which they acquire distinct phenotypes and homeostatic functions shaped by their local environment. Although these cells can arise from either ...