Differences in the cell-wall architecture drive strain-specific IgA induction by Limosilactobacillus reuteri [0.03%]
鼠李糖乳杆菌菌株特异性诱导肠分泌型IgA的差异取决于细胞壁骨架结构的区别分析
Ran Lu,Brianna K Swartwout,Jee-Hwan Oh et al.
Ran Lu et al.
Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a well-studied commensal bacterium known for various health benefits. Our recent findings reveal that the human-derived strain L. reuteri CF48-3A enhances endogenous neonatal i...
A TNFR2 biparatopic antagonist reverses immune suppression through a crosslinking-resistant and ADCC- independent mechanism [0.03%]
一种TNFR2双表位拮抗剂通过非抗体依赖的细胞介导的细胞毒作用和交联独立机制逆转免疫抑制
Shusu Liu,Zhichao Eric Ai,Jinli Xie et al.
Shusu Liu et al.
Tumor necrosis factor receptor 2 (TNFR2) is a promising immunotherapeutic target due to its high upregulation on immunosuppressive populations, like regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). The clinical effic...
High CD163+CD206+macrophages infiltration in the bone marrow microenvironment of newly diagnosed multiple myeloma patients [0.03%]
新诊断多发性骨髓瘤患者骨髓微环境中高富集CD163+CD206+巨噬细胞
Dong-Hai Han,Ya-Ru Li,Hui-Ping Li et al.
Dong-Hai Han et al.
Multiple myeloma (MM) is a neoplastic disease caused by abnormal clonal plasma cells (PCs) in the bone marrow (BM). Macrophages(MФs) are essential components of BM microenvironment and crucial mediators of PCs. Therefore, investigating alt...
An optimized method to differentiate HL60 cells into neutrophil-like cells [0.03%]
一种优化的诱导HL60细胞向类似中性粒细胞分化的方法
Samuel P Collie,Grant Yu,Suraj S Rawat et al.
Samuel P Collie et al.
The HL60 promyelocytic leukemia cell line is widely used to investigate neutrophil biology due to its genetic tractability and accessibility. HL60 cells can be differentiated into neutrophil-like cells using all-trans retinoic acid (ATRA) o...
The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with metastatic cancer: a phase II single arm, open label trial [0.03%]
靶向CD33抗体药物偶联物Gemtuzumab Ozogamicin在转移性肿瘤患者中耗竭并功能重编程CD33阳性髓系来源抑制细胞：一项单臂、开放标签II期临床试验
Carmela De Santo,Aimee Jackson,Francis Mussai et al.
Carmela De Santo et al.
We previously demonstrated that the anti-CD33 antibody drug conjugate, gemtuzumab ozogamicin (GO) binds CD33-expressing monocytic myeloid-derived suppressor cells (M-MDSCs), is internalised, and decreases their viability. Treatment of MDSCs...
HIF-1α in macrophage polarization: roles in immunometabolism and autoimmune diseases [0.03%]
巨噬细胞极化中的HIF-1α：在免疫代谢和自身免疫性疾病中的作用
Dongye Li,Xihao Pan,ZiJin He et al.
Dongye Li et al.
Hypoxia-inducible factor-1α (HIF-1α) is a central regulator of cellular responses to hypoxia and plays a pivotal role in immune cell activation and functional reprogramming. This review summarizes how HIF-1α modulates inflammatory respon...
Neutrophils in Tumorigenesis and Progression: Dual Roles and Clinical Translation [0.03%]
中性粒细胞在肿瘤发生发展中的双刃剑作用及临床转化研究展望
Kexin Hu,Hongyu Li,Puwei Huang et al.
Kexin Hu et al.
Neutrophils, the most abundant innate immune cells, act as first responders in host defense via phagocytosis, degranulation, ROS production and Neutrophil Extracellular Traps (NETs) formation. Emerging evidence reveals that neutrophils are ...
Rotavirus-specific intestinal resident memory T cells induced by oral vaccination in early-life mice may contribute to protective immunity [0.03%]
口服给药诱导的小鼠肠道驻留记忆T细胞对轮状病毒具有特异性并可能参与保护性免疫反应
Catherine Montenegro,Martín Alonso Rondón,Siyuan Ding et al.
Catherine Montenegro et al.
Resident memory T cells (Trm) are key mediators of protective immunity at barrier sites, yet their development during early life remains poorly defined. Here, we show that early-life oral vaccination with a heterologous rhesus rotavirus (RV...
Conjugated bilirubin reduces hepatitis E virus infectivity by modulating immunometabolic processes [0.03%]
结合胆红素通过调节免疫代谢过程来降低HEV感染性
Javier Orozco-Cordoba,Julio Y Anaya-Covarrubias,Minerva D Santiago et al.
Javier Orozco-Cordoba et al.
Despite the landmark discovery of the hepatitis E virus (HEV) four decades ago and its status as the leading cause of viral hepatitis worldwide, the infection remains overlooked in numerous countries. Currently, there are no approved treatm...
A Narrative Review of the mtDNA-Stimulated Inflammatory Axis in Sepsis-Induced Acute Lung Injury: Cellular Mechanisms and Therapeutic Targeting [0.03%]
线粒体DNA诱导的炎症通路在脓毒症急性肺损伤中的作用机制及治疗靶点：综述文章
Shuqi Ma,Qiusha Pan,Ruifeng Zeng et al.
Shuqi Ma et al.
Sepsis-induced acute lung injury (SALI) represents a life-threatening condition with complex pathophysiology. Emerging evidence highlights the mitochondrial DNA (mtDNA)-stimulated inflammatory axis as a pivotal mechanism driving pulmonary i...