Follicular regulatory T cell biology and its role in immune-mediated diseases [0.03%]
滤泡调节性T细胞的生物学及其在自身免疫性疾病中的作用
Yishan Ye,Mowang Wang,He Huang
Yishan Ye
Follicular regulatory T (Tfr) cells are recently found to be a special subgroup of regulatory T (Treg) cells. Tfr cells play an important role in regulating the germinal center (GC) response, especially modulating follicular helper T (Tfh) ...
Emergence of immunosuppressive LOX-1+ PMN-MDSC in septic shock and severe COVID-19 patients with acute respiratory distress syndrome [0.03%]
脓毒症和严重COVID-19急性呼吸窘迫综合征患者的免疫抑制性LOX-1+PMN-MDSC的出现
Rémy Coudereau,Louis Waeckel,Martin Cour et al.
Rémy Coudereau et al.
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with immunosuppressive properties. In cancer patients, the expression of lectin-type oxidized LDL receptor 1 (LOX-1) on granulocytic MDSC ident...
Tanshinone IIA enhances susceptibility of non-small cell lung cancer cells to NK cell-mediated lysis by up-regulating ULBP1 and DR5 [0.03%]
丹参酮 ⅡA通过上调ULBP1和DR5增强NK细胞对非小细胞肺癌细胞的裂解作用
Yufang Sun,Chenyuan Gong,Zhongya Ni et al.
Yufang Sun et al.
Natural killer (NK) cells have a great potential in cancer immunotherapy. However, their therapeutic efficacy is clinically limited owing to cancer cell immune escape. Therefore, it is urgently necessary to develop novel method to improve t...
Hepatic F4/80+ CD11b+ CD68- cells influence the antibacterial response in irradiated mice with sepsis by Enterococcus faecalis [0.03%]
辐照脓毒症小鼠模型中肠球菌引起肝内F4/80+CD11b+CD68-细胞对细菌反应的影响研究
Norio Okamoto,Hideko Ohama,Masahiro Matsui et al.
Norio Okamoto et al.
Gut-associated sepsis is a major problem in patients undergoing abdominal radiation therapy; the majority of pathogens causing this type of sepsis are translocated from the gut microbiota. While treating sepsis, bacterial clearance must be ...
Ye Tu,Ran Yang,Xin Xu et al.
Ye Tu et al.
The gastrointestinal tract is colonized by trillions of microorganisms, consisting of bacteria, fungi, and viruses, known as the "second gene pool" of the human body. In recent years, the microbiota-gut-bone axis has attracted increasing at...
ATR kinase activity promotes antibody class switch recombination in B cells through cell cycle regulation without suppressing DSB resection and microhomology usage [0.03%]
ATR激酶活性通过细胞周期调节促进B细胞中的抗体类别转换重组而不抑制DNA末端切除和微同源序列使用
Xikui Sun,Meiling Liu,Jingning Bai et al.
Xikui Sun et al.
Class switch recombination (CSR) changes the effector functions of antibodies and is carried out by classical and alternative nonhomologous end joining (c-NHEJ and A-EJ) of repetitive switch (S) region double-strand breaks (DSBs). The maste...
Lymphocytes sense antibodies through human FCRL proteins: Emerging roles in mucosal immunity [0.03%]
人类FCRL蛋白通过淋巴细胞感知抗体：黏膜免疫中的新角色
Mate Tolnay
Mate Tolnay
Members of the Fc receptor-like (FCRL) family modulate B and T cell responses, yet their functional roles remain enigmatic. Nevertheless, FCRL3 promoter polymorphism that alters gene expression has been associated with autoimmune disease ri...
CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils [0.03%]
人中性粒细胞上的进化上保守的活化受体CD200R1L
M Inês Pascoal Ramos,Can Keşmir,Jorn E Stok et al.
M Inês Pascoal Ramos et al.
Inhibitory and activating immune receptors play a key role in modulating the amplitude and duration of immune responses during infection and in maintaining immune balance in homeostatic conditions. The CD200 Receptor (CD200R) gene family in...
Phenotypes, roles, and modulation of regulatory lymphocytes in periodontitis and its associated systemic diseases [0.03%]
牙周病及其相关系统疾病的调节性淋巴细胞的表型、作用及调控
Hang Zou,Niu Zhou,Yilian Huang et al.
Hang Zou et al.
Periodontitis is a common chronic inflammatory disease that can result in tooth loss and poses a risk to systemic health. Lymphocytes play important roles in periodontitis through multiple mechanisms. Regulatory lymphocytes including regula...
Safety analysis of ex vivo-expanded canine natural killer cells in a xenogeneic mouse model of graft-versus-host disease [0.03%]
犬源性NK细胞的体外扩增及其在人源HLA转基因小鼠GVHD模型中的安全性研究
Cheol-Jung Kim,Se-Cheol Park,Soo-Hyeon Lee et al.
Cheol-Jung Kim et al.
Canine natural killer (NK) cells are large, granular lymphocytes that are neither B lymphocytes nor T lymphocytes. However, it has been reported that canine NK cells share some of the phenotypic characteristics of T lymphocytes, such as CD3...