Phase Ib Study to Assess the Safety of Neoadjuvant Trifluridine/Tipiracil With Concurrent Radiation in Resectable Stage II/III Rectal Cancer: The FIERCE Study [0.03%]
术前曲氟尿苷联合泰Leap与同期放疗治疗可切除的II/III期直肠癌的Ib期研究：FIERCE研究
Emerson Y Chen,Nima Nabavizadeh,Nicholas D Kendsersky et al.
Emerson Y Chen et al.
Background: Trifluridine has demonstrated superior radio-sensitizing ability in vitro, and trifluridine/tipiracil (FTD/TPI) confers clinical benefit in metastatic colorectal cancer. The FIERCE trial (NCT04104139) sought t...
Lenvatinib Plus Pembrolizumab for Patients With Previously Treated Advanced Colorectal Cancer: Results From the Phase II LEAP-005 Study [0.03%]
仑伐替尼联合派姆单抗治疗既往接受过治疗的晚期结直肠癌患者：LEAP-005Ⅱ期试验结果
Iván Victoria Ruiz,Nataliya V Uboha,Rahima Jamal et al.
Iván Victoria Ruiz et al.
Background: Current treatments for patients with previously treated metastatic colorectal cancer (CRC) have poor outcomes. LEAP-005 (ClinicalTrials.gov, NCT03797326) was a multicohort, open-label phase II study evaluating...
Circulating Tumor DNA as a Biomarker for Recurrence After Curative Resection of Colorectal Cancer Liver Metastases: A Systematic Review and Meta-Analysis [0.03%]
Atta Ullah Khan,Abdul Ahad Mehboob,Asraa Abdulsahib Yousif et al.
Atta Ullah Khan et al.
Colorectal liver metastases (CRLM) remain a leading cause of cancer-related mortality, with recurrence rates of 50 to 70% following curative-intent hepatic resection. Circulating tumor DNA (ctDNA) has emerged as a promising biomarker for mi...
Brain Metastasis From Anal Canal Squamous Cell Carcinoma: A Rare Case Report and Systematic Review [0.03%]
罕见的肛管鳞状细胞癌脑转移病例报告及系统回顾
Miriam Tomaciello,Mauro Palmieri,Massimo Corsini et al.
Miriam Tomaciello et al.
Anal canal squamous cell carcinoma (ACSCC) is a rare malignancy, accounting for approximately 2% of all colorectal cancers. Brain metastases originating from this primary site are exceedingly uncommon and scarcely documented. The aim of thi...
Successful Encorafenib and Cetuximab Re-Challenge Combined With Nivolumab in BRAF V600E Mutated, Mismatch-Repair-Proficient Metastatic Colorectal Cancer - A Case Report From the AGMT mCRC Registry [0.03%]
恩考芬尼和西妥昔单抗联合纳武利尤单抗治疗BRAF V600E突变、错配修复完整型转移性结直肠癌的再挑战研究——AGMT mCRC注册报告的一个病例研究报告
Iason Theodorou,Ronald Heregger,Richard Greil et al.
Iason Theodorou et al.
The Role of Systemic Chemotherapy to Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Patients With Appendiceal Cancers [0.03%]
系统化疗在回盲部肿瘤腹腔细胞减灭术及腹腔热灌注化疗中作用的专家共识（2018版）
Gagandeep Brar,Dani Castillo,Thinzar Lwin et al.
Gagandeep Brar et al.
Background: Appendiceal cancer frequently presents with peritoneal metastases. Cytoreductive surgery combined (CRS) with heated intraperitoneal chemotherapy (HIPEC) is currently standard practice for metastatic appendicea...
Randomized phase III Study of Adding Paclitaxel to Chemoradiotherapy With Capecitabine and Mitomycin C in Squamous Cell Anal Carcinoma [0.03%]
卡培他滨、丝裂霉素联合多西他赛对比卡培他滨、丝裂霉素治疗肛管鳞状细胞癌的随机III期临床研究
Sergey S Gordeyev,Marina V Chernykh,Mikhail Yu Fedyanin et al.
Sergey S Gordeyev et al.
Purpose: In our pilot study adding paclitaxel to chemoradiotherapy (CRT) with capecitabine and mitomycin C (MMC) showed promising efficacy and we aimed to determine whether it could improve progression-free survival (PFS)...
Bowel Stenosis Following Immunotherapy in dMMR Colorectal Cancer: A Case Series [0.03%]
dMMR结直肠癌免疫治疗后肠道狭窄的病例系列研究
Ahmad Gebai,Francine Aubin,Martin Borduas et al.
Ahmad Gebai et al.
Very Early-Onset Colorectal Cancer: Need for a Sub-Category Based on Differences in Tumor Biology, Metastatic and Survival Patterns? A Population-Based Cohort Study [0.03%]
基于肿瘤生物学、转移和生存模式的差异，非常早发结直肠癌需要分类为亚型吗？一项基于人群队列的研究
Abdul Qahar K Yasinzai,Qaidar Alizai,Danish Ali et al.
Abdul Qahar K Yasinzai et al.
Background: The incidence of early-onset colorectal cancer (eoCRC)-diagnosed before age 50-has been increasing annually. Notably, there is significant heterogeneity in the biology within the eoCRC group, yet the specific ...
Effects of Cancer Treatment on Inflammation in Colorectal Cancer Patients: A Longitudinal Study [0.03%]
结直肠癌患者癌症治疗对炎症的影响：一项纵向研究
Anouk E C Bruijnzeels,Floortje Mols,Katrijn Van Deun et al.
Anouk E C Bruijnzeels et al.
Background: Colorectal cancer (CRC) treatment commonly involves surgery combined with chemotherapy (CT) and/or radiotherapy (RT), which can trigger acute and chronic immune alterations. Understanding treatment-related inf...