Structural robustness and temporal vulnerability of the starvation-responsive metabolic network in healthy and obese mouse liver [0.03%]
健康小鼠和肥胖小鼠肝脏适应饥饿的代谢网络的结构鲁棒性和时间脆弱性
Keigo Morita,Atsushi Hatano,Toshiya Kokaji et al.
Keigo Morita et al.
Adaptation to starvation is a multimolecular and temporally ordered process. We sought to elucidate how the healthy liver regulates various molecules in a temporally ordered manner during starvation and how obesity disrupts this process. We...
Re-epithelialization of cancer cells increases autophagy and DNA damage: Implications for breast cancer dormancy and relapse [0.03%]
癌细胞的再上皮化增加自噬和DNA损伤：乳腺癌休眠和复发的意义
Diana Drago-Garcia,Suvendu Giri,Rishita Chatterjee et al.
Diana Drago-Garcia et al.
Cellular plasticity mediates tissue development as well as cancer growth and progression. In breast cancer, a shift to a more epithelial phenotype (epithelialization) underlies a state of reversible cell growth arrest called tumor dormancy,...
John F Foley
John F Foley
A blended proteomics platform provides new depth to the proteome of breast cancer.
A drug that induces the microRNA miR-124 enables differentiation of retinoic acid-resistant neuroblastoma cells [0.03%]
一种能够诱导miR-124的药物可使视黄酸耐药神经母细胞瘤细胞分化
Lien D Nguyen,Satyaki Sengupta,Kevin I Cho et al.
Lien D Nguyen et al.
Tumor cell heterogeneity in neuroblastoma, a pediatric cancer arising from neural crest-derived progenitor cells, presents clinical challenges. Unlike adrenergic (ADRN) neuroblastoma cells, neuroblastoma cells with a mesenchymal (MES) ident...
The dose makes the poison [0.03%]
剂量决定毒性
Wei Wong
Wei Wong
Covalent protein modification with endogenously produced cyanide supports mammalian cell proliferation.
Dynamic modulation of the motor neuron translatome during developmental synapse elimination [0.03%]
发育性突触消除过程中运动神经元转录组的动态调节机制研究
Dinja van der Hoorn,Fabio Lauria,Helena Chaytow et al.
Dinja van der Hoorn et al.
The developmental sculpting of neuromuscular circuitry in early postnatal life occurs through the process of synapse elimination: Supernumerary axon inputs are gradually eliminated from the neuromuscular junction (NMJ), resulting in each mu...
Amy E Baek
Amy E Baek
Glutamate is required for macrophage-driven liver regeneration.
Sierra P Feeney,Jordan M McCarthy,Cecilia R Petruconis et al.
Sierra P Feeney et al.
Sleep loss dysregulates cellular metabolism and energy homeostasis. Highly metabolically active cells, such as neurons, enter a catabolic state during periods of sleep loss, which consequently disrupts physiological functioning. Specific to...
The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis [0.03%]
抗精神病药物硫利达嗪通过诱导鸟氨酸琥珀酸转氨酶1和持续性促吞噬作用刺激巨噬细胞清除病原细胞
Yoko Kojima,Zhongde Ye,Fudi Wang et al.
Yoko Kojima et al.
Stimulating efferocytosis, the phagocytic removal of apoptotic cells by macrophages, has been proposed as a method to eliminate dying or dead cells that accumulate and contribute to diseases such as cancer, atherosclerosis, and infection. T...
Annalisa M VanHook
Annalisa M VanHook
Ethanol impairs sleep in fruit flies by inhibiting cholinergic neurons.