Loss-of-function Gαs rare disease variants exert mutation-specific effects on GPCR signaling [0.03%]
功能缺失Gαs罕见疾病变异体对GPCR信号转导具有突变特异性效应
Theo Redfern-Nichols,Shannon L O&#x;Brien,Xianglin Huang et al.
Theo Redfern-Nichols et al.
G protein-coupled receptors (GPCRs) are transmembrane detectors of extracellular signals that activate heterotrimeric G proteins to regulate intracellular responses. Because there are only 16 Gα proteins that can couple to GPCRs, variation...
Morphological control of merlin-Rac antagonism in proliferation-promoting signaling [0.03%]
形态控制merlin-rac在促进增殖信号传递中的拮抗作用
Byron G Weiss,Justine M Keth,Kushal Bhatt et al.
Byron G Weiss et al.
The extension of lamellipodia, which are thin, fanlike projections at the cell periphery, requires the assembly of branched actin networks under the control of the small GTPase Rac1. In melanoma, a hyperactive P29S Rac1 mutant is associated...
Technical recommendations for analyzing oxylipins by liquid chromatography-mass spectrometry [0.03%]
液相色谱-质谱法分析氧脂素的技术建议
Nils Helge Schebb,Nadja Kampschulte,Gerhard Hagn et al.
Nils Helge Schebb et al.
Several oxylipins are potent lipid mediators that regulate diverse aspects of health and disease and whose quantitative analysis by liquid chromatography-mass spectrometry (LC-MS) presents substantial technical challenges. As members of the...
Adherens junctions co-opt EGFR-ERK signaling for epithelial mechanotransduction [0.03%]
粘附连接募集EGFR-ERK信号通路用于上皮机械转导
Ellen K Potoczky,Alpha S Yap
Ellen K Potoczky
In this issue of Science Signaling, Houtekamer et al. report a mechanism by which adherens junctions enable epithelia to respond to mechanical stress. They demonstrate that E-cadherin-containing adhesions stimulate ERK signaling in response...
Annalisa M VanHook
Annalisa M VanHook
Chronic stress impairs intestinal stem cell function through the parasympathetic nervous system.
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding [0.03%]
上皮单层中的E-钙黏着蛋白机械转导通过诱导ADAM介导的配体释放激活EGFR-ERK信号通路
Ronja M Houtekamer,Mirjam C van der Net,Marjolein J Vliem et al.
Ronja M Houtekamer et al.
The behavior of cells is governed by signals originating from their local environment, including mechanical forces exerted on the cells. Forces are transduced by mechanosensitive proteins, which can impinge on signaling cascades that are al...
ADAR2-mediated Q/R editing of GluA2 in homeostatic synaptic plasticity [0.03%]
ADAR2介导的GluA2Q/R编辑在稳态突触可塑性中的作用
Lucy Peterson,Richard Coca,Shreya Parikh et al.
Lucy Peterson et al.
Homeostatic synaptic plasticity is a negative feedback mechanism through which neurons modify their synaptic strength to counteract chronic increases or decreases in activity. In response to activity deprivation, synaptic strength is enhanc...
A good side of STING [0.03%]
STING阳性的一面
Leslie K Ferrarelli
Leslie K Ferrarelli
The innate immunity mediator STING senses and repairs lysosomal dysfunction.
Pericytes under pressure: TRPC3 channels as gatekeepers of capillary flow [0.03%]
受压的周细胞：TRPC3通道作为毛细血管血流的调节器
Scott Earley
Scott Earley
Intrinsic control of cerebral blood flow in response to intravascular pressure is traditionally attributed to smooth muscle cells in arterioles. However, in this issue of Science Signaling, Ferris et al. demonstrate that capillary constrict...
Increased luminal pressure in brain capillaries drives TRPC3-dependent depolarization and constriction of transitional pericytes [0.03%]
脑毛细血管管腔内压增高通过TRPC3依赖性去极化和收缩过渡态周细胞来介导阻力的增加
Hannah R Ferris,Danielle A Jeffrey,Mayra Bueno Guerrero et al.
Hannah R Ferris et al.
Cerebral autoregulation ensures constant blood flow, an essential condition of brain health. A fundamental parameter of the brain circulation is the dynamic regulation of microvessel diameter to allow for adjustments in resistance to blood ...