Autophosphorylation of oncoprotein TEL-ABL in myeloid and lymphoid cells confers resistance to the allosteric ABL inhibitor asciminib [0.03%]
髓系和淋巴组织细胞中的致癌蛋白TEL-ABL自磷酸化赋予其对ABL变构抑制剂asciminib的耐药性
Serena Muratcioglu,Christopher A Eide,Chien-Lun Hung et al.
Serena Muratcioglu et al.
Chromosomal translocations that fuse ABL1 to BCR or TEL cause human leukemias. In BCR-ABL and TEL-ABL fusion proteins, oligomerization and loss of an autoinhibitory myristoylation site in the SH3 domain of ABL lead to increased ABL tyrosine...
Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins [0.03%]
RIPK3定位于星形胶质细胞中通过转录诱导serpin发挥抗炎保护作用对抗小鼠病毒性脑炎
Marissa Lindman,Irving Estevez,Eduard Marmut et al.
Marissa Lindman et al.
Flaviviruses pose a substantial threat to public health because of their ability to infect the central nervous system (CNS). Receptor-interacting protein kinase 3 (RIPK3) is a central coordinator that promotes neuroinflammation during viral...
Evolution of growth factor signaling to the TSC complex to regulate mTORC1 [0.03%]
生长因子信号转导至TSC复合体以调节mTORC1的发展变迁
Kun Wang,Sophie E Lockwood,Brendan D Manning
Kun Wang
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates signals from factors that both stimulate (exogenous growth factors) and are essential for (intracellular nutrients and energy) cellular growth. Activation of the prote...
Leslie K Ferrarelli
Leslie K Ferrarelli
Parkinson's disease-associated α-synuclein impairs autophagy by hijacking the cell's acetylation machinery.
The MDM2-p53 axis regulates norrin/frizzled4 signaling and blood-CNS barrier function [0.03%]
MDM2-p53轴调控Norrin-Frizzled4信号通路及血脑屏障功能
Jacklyn Levey,Md Abedin,Chi Zhang et al.
Jacklyn Levey et al.
Norrin-induced activation of β-catenin-dependent signaling through the receptor frizzled4 in endothelial cells (ECs) is essential for establishing and maintaining blood-CNS barrier function. We sought to determine how this pathway is modul...
Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson's disease-linked LRRK2-mutant mice [0.03%]
通过激酶抑制剂治疗帕金森病相关LRRK2突变小鼠以恢复黑质保护途径
Ebsy Jaimon,Yu-En Lin,Francesca Tonelli et al.
Ebsy Jaimon et al.
Parkinson's disease is associated with activating mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2), which suppresses primary cilia formation in cholinergic and parvalbumin interneurons and astrocytes in the striatum. As a...
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease [0.03%]
PKCη错义突变增强高尔基体定位信号并与常染色体隐性遗传的家族性阿尔茨海默病相关
Maria Celeste Gauron,Dmitry Prokopenko,Sanghun Lee et al.
Maria Celeste Gauron et al.
The identification of Alzheimer's disease (AD)-associated genomic variants has provided powerful insight into disease etiology. Genome-wide association studies (GWASs) of AD have successfully identified previously unidentified targets but h...
Annalisa M VanHook
Annalisa M VanHook
Glycosaminoglycans enable cancer cells to take up antiferroptotic lipoproteins.
The lncRNA Gas5 is an activity-responsive scaffold that mediates cAMP-dependent synaptic plasticity [0.03%]
Gas5是cAMP依赖的突触可塑性的响应活性支架调控长非编码RNA
Kaushik Chanda,Eddie Grinman,Kaylyn Clark et al.
Kaushik Chanda et al.
Changes in the transcriptome are critical in shaping the structural plasticity of neurons, which underpins learning and long-term memory storage. Here, we explored the effect of two opposing, plasticity-associated pathways-cAMP second-messe...
Loss of STIM2, but not of STIM1, drives colorectal cancer metastasis through metabolic reprogramming and the ATF4 ER stress pathway [0.03%]
STIM2缺失通过代谢重编程和ATF4内质网应激途径驱动结直肠癌转移，而STIM1缺失则不具有此作用
Trayambak Pathak,J Cory Benson,Martin T Johnson et al.
Trayambak Pathak et al.
The large amounts of calcium (Ca2+) stored in the endoplasmic reticulum (ER) and the controlled release of this Ca2+ store into the cytosol regulate many cellular functions, and altered ER Ca2+ homeostasis induces ER stress. Stromal-interac...