The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibition [0.03%]
长链非编码RNA EPIC1通过抑制dsRNA诱导的I型干扰素信号通路成为增强三阴性乳腺癌PD-1抑制治疗反应的潜在治疗靶点
Dhamotharan Pattarayan,Yue Wang,Zehua Wang et al.
Dhamotharan Pattarayan et al.
Increases in retroelement-derived double-stranded RNAs (dsRNAs) in various types of cancer cells facilitate the activation of antitumor immune responses. The long noncoding RNA EPIC1 interacts with the histone methyltransferase EZH2 and con...
The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in pancreatic cancer cells [0.03%]
ERK激酶在胰腺癌细胞上皮间质转化异质性中扮演保守的核心角色
Michelle C Barbeau,Brooke A Brown,Sara J Adair et al.
Michelle C Barbeau et al.
Epithelial-mesenchymal transition (EMT) occurs heterogeneously among carcinoma cells to promote chemoresistance. Identifying the signaling pathways involved will nominate drug combinations to promote chemoresponse, but cell population-level...
Tailored receptor modulators [0.03%]
定制化受体调节剂
John F Foley
John F Foley
Positive allosteric modulators of free fatty acid receptor 2 induce distinct conformations to bias G protein signaling.
Anthony C Restaino,Maryam Ahmadi,Tuany Eichwald et al.
Anthony C Restaino et al.
Small extracellular vesicles (sEVs) released from tumors recruit nociceptor neurons to the tumor bed. Here, we found that ablating these neurons in mouse models of head and neck carcinoma and melanoma reduced the infiltration of myeloid-der...
Tumor-derived small extracellular vesicles reprogram sensory nerves to drive immunosuppression in the tumor microenvironment [0.03%]
肿瘤衍生的小细胞外囊泡通过重新编程感觉神经在肿瘤微环境中发挥免疫抑制作用
Leah Boyd,Jeremy C Borniger
Leah Boyd
Neuroimmune cross-talk is emerging as an important regulator of tumor growth and progression in cancers beyond the central nervous system. In this issue of Science Signaling, Restaino et al. demonstrate that tumor-derived small extracellula...
Proteomic analyses identify targets, pathways, and cellular consequences of oncogenic KRAS signaling [0.03%]
蛋白质组分析识别出了癌基因KRAS信号转导的靶点、途径及其细胞后果
Nicole Kabella,Florian P Bayer,Konstantinos Stamatiou et al.
Nicole Kabella et al.
Mutations that activate the small GTPase KRAS are a frequent genetic alteration in cancer, and drug discovery efforts have led to inhibitors that block KRAS activity. We sought to better understand oncogenic KRAS signaling and the cytostati...
USP5 deubiquitylates and stabilizes FcεRIγ to enhance IgE-induced mast cell activation and allergic inflammation [0.03%]
USP5通过去泛素化和稳定FCERI伽马来增强IgE诱导的肥大细胞活化及过敏性炎症反应
Zi-Wen Zhou,Xue-Ting Xu,Qiu-Ni Liang et al.
Zi-Wen Zhou et al.
Antigen-mediated aggregation of immunoglobulin E (IgE) bound to the high-affinity IgE receptor (FcεRI) initiates mast cell activation and allergic inflammation. Here, we investigated the role of ubiquitin-specific protease 5 (USP5) in IgE-...
Wei Wong
Wei Wong
Sphingomyelins in mosquito saliva enhance flavivirus infection by preventing viral protein degradation.
Deletion of PTP1B in cardiomyocytes alters cardiac metabolic signaling to protect against cardiomyopathy induced by a high-fat diet [0.03%]
心脏成纤维细胞中PTP1B缺失通过重塑代谢和内皮功能来改善肥胖性心肌病
Yan Sun,Abhishek Kumar Mishra,Vasanth Chanrasekhar et al.
Yan Sun et al.
Cardiomyocytes (CMs) normally use fatty acid oxidation (FAO) as their primary energy source. In response to pathological stress, the substrate preference of CMs switches from FAO to glucose metabolism, leading to the development of heart fa...
Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer [0.03%]
基于报告基因的筛查鉴定出了RAS-RAF突变是结直肠癌激活态RAS抑制剂耐药性的驱动因素
Oleksandra Aust,Moritz R T Thiel,Eric Blanc et al.
Oleksandra Aust et al.
Therapy-induced acquired resistance limits the clinical effectiveness of mutation-specific KRAS inhibitors in colorectal cancer (CRC). Here, we investigated whether broad-spectrum, active-state RAS inhibitors meet similar limitations. We fo...