Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1 [0.03%]
白细胞介素15和18通过非经典活化方式激活mTORC1协同启动天然杀伤细胞的抗肿瘤功能
Lucie Fallone,Kévin Pouxvielh,Laure Arbez et al.
Lucie Fallone et al.
The multiprotein complex mTORC1 is essential for the increase in protein synthesis and bioenergetic metabolism that supports the proliferation of many cell types, including natural killer (NK) cells, which are important innate effectors of ...
Fusobacterium nucleatum enhances amphetamine-induced behavioral responses through a butyrate-driven epigenetic mechanism [0.03%]
具核梭杆菌通过丁酸盐介导的表观遗传机制增强苯丙胺引起的神经行为反应
Samuel J Mabry,Xixi Cao,Yanqi Zhu et al.
Samuel J Mabry et al.
Amphetamines are psychostimulants that are commonly used to treat neuropsychiatric disorders and are prone to misuse. The pathogenesis of amphetamine use disorder (AUD) is associated with dysbiosis (an imbalance in the body's microbiome) an...
Identification of proteins in semen-derived extracellular vesicles that bind to Tat and NF-κB and that may impair HIV replication [0.03%]
识别结合HIV-1 Tat和NF-κB并可能抑制HIV复制的精液衍生外泌体蛋白
Bryson C Okeoma,Hussein Kaddour,Wasifa Naushad et al.
Bryson C Okeoma et al.
Replication of HIV-1 requires the coordinated action of host and viral transcription factors, most critically the viral transactivator Tat and the host nuclear factor κB (NF-κB). This activity is disrupted in infected cells that are cultu...
APOE ε4 on immunity [0.03%]
载脂蛋白ε4与免疫反应
Leslie K Ferrarelli
Leslie K Ferrarelli
APOE ε4 dysregulates systemic immunity, creating vulnerability for neurodegenerative disease.
Gαq signaling in primary sensory neurons shifts opioid analgesia to NMDA receptor-driven tolerance and hyperalgesia [0.03%]
初级感觉神经元中Gαq信号转导使阿片类药物镇痛作用转化为NMDA受体介导的耐受性和痛觉过敏现象
Daozhong Jin,Hong Chen,Meng-Hua Zhou et al.
Daozhong Jin et al.
Opioids relieve pain by activating μ-opioid receptors (MORs), which inhibit communication between pain-sensing neurons (nociceptors) and the spinal cord. However, prolonged opioid use can paradoxically lead to increased pain sensitivity (h...
MAPK and mTORC1 signaling converge to drive cyclin D1 protein production to enable cell cycle reentry in melanoma persister cells [0.03%]
MAPK和mTORC1信号的汇聚驱动cyclin D1蛋白产生以使黑色素瘤持久存在细胞重新进入细胞周期
Varuna Nangia,Humza Ashraf,Nasreen Marikar et al.
Varuna Nangia et al.
In BRAF-mutant melanoma cells treated with inhibitors of the kinases BRAF and MEK, a subset of cells rapidly and nongenetically adapts to escape drug-induced quiescence and reenters the cell cycle. Here, we investigated the mechanisms enabl...
Analysis of stress-induced small proteins in Escherichia coli reveals that YoaI mediates cross-talk between distinct signaling systems [0.03%]
对大肠杆菌中应激诱导的小分子蛋白的分析表明YoaI在不同的信号系统之间传递信息
Sangeevan Vellappan,Junhong Sun,John Favate et al.
Sangeevan Vellappan et al.
Bacterial small proteins (≤50 amino acids) are an emerging class of regulators that modulate the activity of signaling networks that enable bacterial adaptation to stress. The Escherichia coli genome encodes at least 150 small proteins, mo...
Annalisa M VanHook
Annalisa M VanHook
Estrogen protects against kidney injury through both genomic and nongenomic mechanisms.
Hox-C12 coordinates β2-adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer [0.03%]
HOX-C12通过β2-肾上腺素受体与cAMP/钙离子前馈环的偶联驱动三阴性乳腺癌侵袭转移
Terrance Lam,Bailey Cardwell,Bonan Liu et al.
Terrance Lam et al.
Noradrenaline released from sympathetic neurons accelerates cancer metastasis by activating β2-adrenergic receptors (β2-adrenoceptors) on tumor cells to promote invasion. We previously showed that the β2-adrenoceptor promotes invasive be...
Amylin receptor subunit interactions are modulated by agonists and determine signaling [0.03%]
淀粉肽受体亚基间的相互作用由激动剂调节并决定信号转导
Sandra E Gostynska,Jordan A Karim,Bailee E Ford et al.
Sandra E Gostynska et al.
Three amylin receptors (AMYRs) mediate the metabolic actions of the peptide hormone amylin and are drug targets for diabetes and obesity. AMY1R, AMY2R, and AMY3R are heterodimers consisting of the calcitonin receptor (CTR), a G protein-coup...