Senataxin promotes recombination fidelity during antigen receptor gene diversification [0.03%]
生发中心反应中促进抗原受体基因多样性化的重组忠实性蛋白质研究
Alice Billie Libri,Jinglong Wang,Timea Marton et al.
Alice Billie Libri et al.
Antigen receptor diversity depends on the assembly of variable (V), diverse (D), and joining (J) exons in genes encoding immunoglobulins (Igs) and T cell receptors (TCRs). During V(D)J recombination, DNA double-strand breaks (DSBs) introduc...
John F Foley
John F Foley
Coordinated posttranslational modifications of cysteine residues regulate STING oligomerization and function.
An ectopic Hedgehog signaling axis drives directional tumor outgrowth in a mouse model of hereditary multiple osteochondromas [0.03%]
在遗传性多骨软骨瘤小鼠模型中异常的Hedgehog信号轴驱动肿瘤定向生长
Sarah E Catheline,Christina Mundy,Cheri Saunders et al.
Sarah E Catheline et al.
Osteochondromas characterize the rare pediatric disorder hereditary multiple osteochondromas (HMO). The tumors originate from the growth plate perichondrium along skeletal elements, appear first as ectopic cartilage, and then grow unidirect...
Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke [0.03%]
骨骼肌RYR1丝氨酸2902磷酸化减少Ca2+泄漏、恶性高热和中暑的易感性
Rachel Sue Zhen Yee,Chang Seok Lee,Ting Chang et al.
Rachel Sue Zhen Yee et al.
Ryanodine receptor 1 (RYR1) is the sarcoplasmic reticulum (SR) Ca2+ release channel required for both skeletal muscle contraction and Ca2+ leak. Mutations in RYR1 cause malignant hyperthermia susceptibility (MHS) and enhanced sensitivity to...
Molecular determinants for the endocytosis of the voltage-gated K+ channel Kv1.3 [0.03%]
电压门控钾通道Kv1.3的内吞作用分子决定因素
Irene Estadella,María Navarro-Pérez,Magalí Colomer-Molera et al.
Irene Estadella et al.
The voltage-gated potassium channel Kv1.3 contributes to action potential conduction in sensory neurons and to sustained increases in cytoplasmic Ca2+ that activate immune cells. Here, we found that two distinct endocytosis-inducing stimuli...
Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer [0.03%]
MYC调节的转录组和激酶组的定义，以支持胰腺癌中KRAS和ERK依赖性的生长
Priya S Hibshman,Clint A Stalnecker,Jeffrey A Klomp et al.
Priya S Hibshman et al.
Of the thousands of genes and substrates identified in KRAS-mutant signaling networks in pancreatic ductal adenocarcinoma (PDAC), more than 200 are transcription factors, implying extensive and complex transcriptional regulation. However, w...
Wei Wong
Wei Wong
Mitochondrial stress drives brown fat whitening through a pathway involving reduced nuclear stiffness.
TIM3 is a context-dependent coregulator of cytotoxic T cell function [0.03%]
TIM3是细胞毒性T细胞功能的上下文依赖性共调节因子
Hanin Alamir,Carissa C W Wong,Amal Alsubaiti et al.
Hanin Alamir et al.
TIM3 is a coregulatory receptor that is highly abundant on multiple immune cell types, including T cells in response to prolonged exposure to antigen, and it marks functionally suppressed cytotoxic T lymphocytes (CTLs) in the tumor microenv...
Adenosine 2A receptor-dependent activation of AMPK represses TH17 cell pathogenicity through epigenetic and metabolic reprogramming [0.03%]
A2AR依赖的AMPK激活通过表观遗传和代谢重编程抑制TH17细胞的致病性
Gina Papadopoulou,Dimitrios Valakos,Ioanna Polydouri et al.
Gina Papadopoulou et al.
Metabolic reprogramming controls protective and pathogenic T helper 17 (TH17) cell responses. When naïve T cells are differentiated into TH17 cells in vitro, the presence of the cytokine activin A promotes their maturation into a nonpathog...
Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers [0.03%]
野生型RAS信号传导是RAS突变癌症的治疗靶点
Nancy E Sealover,Bridget A Finniff,Jacob M Hughes et al.
Nancy E Sealover et al.
Mutated RAS proteins activate downstream effector pathways (RAF-MEK-ERK and PI3K-AKT) to drive oncogenic transformation and progression. Because RAS family members differentially engage these pathways, combined inhibition of both pathways i...