Ionizable networks mediate pH-dependent allostery in the SH2 domain-containing signaling proteins SHP2 and SRC [0.03%]
可离子化的网络介导了SHP2和SRC中SH2结构域含蛋白质的pH依赖性别构效应
Papa Kobina Van Dyck,Luke Piszkin,Elijah A Gorski et al.
Papa Kobina Van Dyck et al.
Intracellular pH dynamics regulate many cell biological processes. We developed a computational pipeline to identify pH-sensitive proteins and the molecular mechanisms that regulate their pH-dependent activity. By applying the pipeline to t...
Leslie K Ferrarelli
Leslie K Ferrarelli
Citrullination enhances the tumor-suppressor function of p53 by redirecting its gene target selectivity.
The chordoid glioma PRKCA D463H mutation is a kinase inactive, gain-of-function allele that induces early-onset chondrosarcoma in mice [0.03%]
PRKCA D463H 突变导致小鼠早发性软骨肉瘤的机制研究
Véronique Calleja,Jack C Henry,Mathias Cobbaut et al.
Véronique Calleja et al.
The penetrant D463H mutation in PRKCA, which encodes the kinase PKCα, is a biomarker and driver of chordoid glioma, a type of brain cancer. Here, we found that heterozygous knock-in expression of the D463H mutant in mice elicited the devel...
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation [0.03%]
类白细胞具有透明质硫酸糖萼，在类似银屑病的皮肤炎症中调节募集作用
Megan J Priestley,Anna K Hains,Iashia Z Mulholland et al.
Megan J Priestley et al.
The glycocalyx is a proteoglycan-rich layer present on the surface of all mammalian cells and is particularly prevalent on endothelial cells lining the vasculature. The glycocalyx is thought to affect leukocyte migration by masking adhesion...
Loss of the conserved switch III region in a G protein leads to severe pediatric encephalopathy [0.03%]
视蛋白III保守功能区缺失导致儿童脑病
Mikhail Savitsky,Yonika A Larasati,Gonzalo P Solis et al.
Mikhail Savitsky et al.
The α subunits of heterotrimeric guanine nucleotide-binding proteins (G proteins) in G protein-coupled receptor (GPCR) pathways operate as gate switches by cycling through inactive GDP-bound and active GTP-bound states. Three flexible regi...
Annalisa M VanHook
Annalisa M VanHook
Sensory neurons promote bone homeostasis and repair by providing osteopontin to skeletal stem cells.
Intestine-derived sorbitol drives steatotic liver disease in the absence of gut bacteria [0.03%]
无肠菌时肠道衍生山梨醇可诱发脂肪变性肝病
Madelyn M Jackstadt,Ronald Fowle-Grider,Mun-Gu Song et al.
Madelyn M Jackstadt et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to a shift in the composition of the gut microbiome. Here, we found that depletion of the gut microbiome in adult zebrafish led to the development of steatotic liver...
PARP1-mediated PARylation of TEAD4 stabilizes the YAP1-TEAD4 complex and promotes growth and immune evasion in breast cancer cells [0.03%]
乳腺癌细胞中PARP1介导的TEAD4多聚ADP核糖化稳定YAP1-TEAD4复合物并促进生长和免疫逃逸
Yibo Guo,Gaoqing Song,Hailin Zou et al.
Yibo Guo et al.
The transcriptional coactivator YAP1 regulates numerous biological processes, including organ size control and tissue homeostasis. Although its hyperactivity promotes tumor development and progression, YAP1 itself is not yet druggable. Here...
Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration [0.03%]
调控颅骨再生中缝干细胞激活的损伤诱导生态位因子Cxcl12和Shh/Ihh
Bo Li,Takehito Ouchi,Jie Liu et al.
Bo Li et al.
Stem cells reside in niches that determine how they respond to injury to expand in number, migrate to the injury site, and differentiate into cells to regenerate lost tissue. Suture stem cells (SuSCs) are important for homeostasis and regen...
The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD [0.03%]
E3泛素连接酶ZNRF3通过刺激配体结合的FZD的选择性降解来限制Wnt受体复合物的活性
Bo Lu,Feng Cong
Bo Lu
Ligands of the WNT family induce formation of the WNT receptor signalosome and promote stabilization of the transcriptional coactivator β-catenin. The homologous transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 inhibit WNT-dependent stab...