Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes [0.03%]
抑制Gβγ-SNARE相互作用会破坏GPCR介导的突触前抑制，从而导致生理和行为表型
Zack Zurawski,Analisa D Thompson Gray,Lillian J Brady et al.
Zack Zurawski et al.
G protein-coupled receptors (GPCRs) that couple to Gi/o proteins modulate neurotransmission presynaptically by inhibiting exocytosis. Release of Gβγ subunits from activated G proteins decreases the activity of voltage-gated Ca2+ channels ...
Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential [0.03%]
三叶草C端鸟苷交换因子模块的自动抑制结构揭示了它的致癌潜能
Sumit J Bandekar,Nadia Arang,Ena S Tully et al.
Sumit J Bandekar et al.
The C-terminal guanine nucleotide exchange factor (GEF) module of Trio (TrioC) transfers signals from the Gαq/11 subfamily of heterotrimeric G proteins to the small guanosine triphosphatase (GTPase) RhoA, enabling Gαq/11-coupled G protein...
Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation [0.03%]
谷胱甘肽S-转移酶在脑炎症期间促进促炎性星形胶质细胞-小胶质细胞通讯
Shin-Ichi Kano,Eric Y Choi,Eisuke Dohi et al.
Shin-Ichi Kano et al.
Astrocytes and microglia play critical roles in brain inflammation. Here, we report that glutathione S-transferases (GSTs), particularly GSTM1, promote proinflammatory signaling in astrocytes and contribute to astrocyte-mediated microglia a...
An immunoproteomic approach to characterize the CAR interactome and signalosome [0.03%]
一种表征CAR互作组和信号组的免疫蛋白组学方法
Maria C Ramello,Ismahène Benzaïd,Brent M Kuenzi et al.
Maria C Ramello et al.
Adoptive transfer of T cells that express a chimeric antigen receptor (CAR) is an approved immunotherapy that may be curative for some hematological cancers. To better understand the therapeutic mechanism of action, we systematically analyz...
Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration [0.03%]
炎症、坏死和RIP3激酶是AAG依赖性烷基化诱导的视网膜变性的关键介质
Mariacarmela Allocca,Joshua J Corrigan,Aprotim Mazumder et al.
Mariacarmela Allocca et al.
DNA-alkylating agents are commonly used to kill cancer cells, but the base excision repair (BER) pathway they trigger can also produce toxic intermediates that cause tissue damage, such as retinal degeneration (RD). Apoptosis, a process of ...
Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO [0.03%]
mitochondrial reactive oxygen species通过NEMO二硫键连接促进促炎信号转导
Marc Herb,Alexander Gluschko,Katja Wiegmann et al.
Marc Herb et al.
A major function of macrophages during infection is initiation of the proinflammatory response, leading to the secretion of cytokines that help to orchestrate the immune response. Here, we identify reactive oxygen species (ROS) as crucial m...
Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling [0.03%]
缺氧癌相关成纤维细胞通过增强VEGF信号增加NCBP2-AS2/HIAR促进内皮出芽
Fernanda G Kugeratski,Samuel J Atkinson,Lisa J Neilson et al.
Fernanda G Kugeratski et al.
Intratumoral hypoxia causes the formation of dysfunctional blood vessels, which contribute to tumor metastasis and reduce the efficacy of therapeutic treatments. Blood vessels are embedded in the tumor stroma of which cancer-associated fibr...
Inhibition of T cell activation and function by the adaptor protein CIN85 [0.03%]
衔接蛋白CIN85对T细胞活化和功能的抑制作用
Mei Suen Kong,Akiko Hashimoto-Tane,Yusuke Kawashima et al.
Mei Suen Kong et al.
T cell activation is initiated by signaling molecules downstream of the T cell receptor (TCR) that are organized by adaptor proteins. CIN85 (Cbl-interacting protein of 85 kDa) is one such adaptor protein. Here, we showed that CIN85 limited ...
Interrogating B cell signaling pathways: A quest for novel therapies for mantle cell lymphoma [0.03%]
探究B细胞信号通路：寻觅新的套细胞淋巴瘤疗法
Makhdum Ahmed,Elizabeth Lorence,Jeffrey Wang et al.
Makhdum Ahmed et al.
Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma that is largely chemoresistant. Ibrutinib, a drug that inhibits Bruton's tyrosine kinase (BTK), has improved the overall survival of patients with MCL; however, resistance to ibrut...
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition [0.03%]
通过LSD1抑制作用针对小细胞肺癌的NOTCH活化作用
Arnaud Augert,Emily Eastwood,Ali H Ibrahim et al.
Arnaud Augert et al.
Small cell lung cancer (SCLC) is a recalcitrant, aggressive neuroendocrine-type cancer for which little change to first-line standard-of-care treatment has occurred within the last few decades. Unlike nonsmall cell lung cancer (NSCLC), SCLC...