RIPK3 coordinates RHIM domain-dependent antiviral inflammatory transcription in neurons [0.03%]
RIPK3在神经元中协调RHIM依赖的抗病毒炎症转录
Sigal B Kofman,Lan H Chu,Joshua M Ames et al.
Sigal B Kofman et al.
Neurons are postmitotic, nonregenerative cells that have evolved fine-tuned immunological responses to maintain life-long cellular integrity, including resistance to common programmed cell death pathways such as necroptosis. We previously d...
Leslie K Ferrarelli
Leslie K Ferrarelli
A bacterium in the maternal gut promotes stem cell activity and long-term gut and brain health in offspring.
Sustained chromosomal passenger complex activity preserves the pluripotency of human embryonic carcinoma cells [0.03%]
持续的染色体乘客复合物活性保持了人胚癌细胞的多能性
Takaaki Tsunematsu,Yasuhiro Mouri,Wenhua Shao et al.
Takaaki Tsunematsu et al.
Human embryonic carcinoma (hEC) cells are derived from teratocarcinomas, exhibit robust proliferation, have a high differentiation potential, are the malignant counterparts of human embryonic stem cells (hESCs), and are considered hESC-like...
Sustained Gαs signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and β-arrestin independent [0.03%]
由血管加压素2型受体介导的持续的Gαs信号依赖配体但与内吞和β-抑制蛋白无关
Larissa B Teixeira,Marie-José Blouin,Christian Le Gouill et al.
Larissa B Teixeira et al.
The canonical model of G protein-coupled receptor (GPCR) signaling comprises G protein activation at the plasma membrane, followed by receptor phosphorylation and β-arrestin recruitment, which leads to receptor desensitization and endocyto...
A sensitive biosensor of endogenous Gαi activity enables the accurate characterization of endogenous GPCR agonist responses [0.03%]
一种敏感的内源性Gαi活性生物传感器能够精确地表征内源性GPCR激动剂反应
Alex Luebbers,Remi Janicot,Jingyi Zhao et al.
Alex Luebbers et al.
The activation of heterotrimeric G proteins (Gαβγ) by G protein-coupled receptors (GPCRs) is a mechanism broadly used by eukaryotes to transduce signals across the plasma membrane and a target for many clinical drugs. Many optical biosen...
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells [0.03%]
一种来自狼疮的自身抗体，能够结合到细胞内RNA并激活cGAS介导的肿瘤免疫并且可以将RNA递送到细胞内
Xiaoyong Chen,Xiangjun Tang,Ying Xie et al.
Xiaoyong Chen et al.
Nucleic acid-mediated signaling triggers an immune response that is believed to be central to the pathophysiology of autoimmunity in systemic lupus erythematosus (SLE). Here, we found that a cell-penetrating, SLE-associated antiguanosine au...
Leslie K Ferrarelli
Leslie K Ferrarelli
An antibody delivered nasally after brain injury induces a neuroprotective, anti-inflammatory response.
John F Foley
John F Foley
A synthetic cannabinoid biases CB1 signaling toward G proteins to elicit effective pain relief without tolerance in mice.
Structural analysis reveals how tetrameric tyrosine-phosphorylated STAT1 is targeted by the rabies virus P-protein [0.03%]
结构分析揭示了狂犬病毒P蛋白作用于四聚体酪氨酸磷酸化STAT1的机制
Aoi Sugiyama,Miku Minami,Kaito Ugajin et al.
Aoi Sugiyama et al.
Signal transducer and activator of transcription (STAT) family members mediate signaling in the Janus kinase (JAK)-STAT pathway and are activated by phosphorylation at a conserved tyrosine residue, resulting in dimerization through reciproc...
The kinase PLK1 promotes Hedgehog signaling-dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer [0.03%]
激酶PLK1促进转移性前列腺癌中抗雄激素恩杂鲁胺的Hedgehog信号依赖性耐药性
Qiongsi Zhang,Jia Peng,Yanquan Zhang et al.
Qiongsi Zhang et al.
Enzalutamide, a second-generation androgen receptor inhibitor (also known as an antiandrogen), is used to treat patients with metastatic castration-resistant prostate cancer (CRPC). Tumors often acquire resistance to enzalutamide. Tumor pro...