John A Cooper,David Sept
John A Cooper
The heterodimeric actin capping protein, referred to here as "CP," is an essential element of the actin cytoskeleton, binding to the barbed ends of actin filaments and regulating their polymerization. In vitro, CP has a critical role in the...
Permissive and repulsive cues and signalling pathways of axonal outgrowth and regeneration [0.03%]
轴突生长和再生的允许和排斥信号及信号通路
Sheng T Hou,Susan X Jiang,Robert A Smith
Sheng T Hou
Successful axonal outgrowth in the adult central nervous system (CNS) is central to the process of nerve regeneration and brain repair. To date, much of the knowledge on axonal guidance and outgrowth comes from studies on neuritogenesis and...
Irina M Konstantinova,Anna S Tsimokha,Alexey G Mittenberg
Irina M Konstantinova
The 26S proteasome is the key enzyme of the ubiquitin-dependent pathway of protein degradation. This energy-dependent nanomachine is composed of a 20S catalytic core and associated regulatory complexes. The eukaryotic 20S proteasomes demons...
Rodney J Devenish,Mark Prescott,Andrew J W Rodgers
Rodney J Devenish
We review recent advances in understanding of the structure of the F(1)F(0)-ATP synthase of the mitochondrial inner membrane (mtATPase). A significant achievement has been the determination of the structure of the principal peripheral or st...
Eeva-Liisa Eskelinen
Eeva-Liisa Eskelinen
Macroautophagy is a self-digesting pathway responsible for the removal of long-lived proteins and organelles by the lysosomal compartment. Parts of the cytoplasm are first segregated in double-membrane-bound autophagosomes, which then under...
Role of nuclear lamins in nuclear organization, cellular signaling, and inherited diseases [0.03%]
核纤层蛋白在细胞核组织、信号传导和遗传疾病中的作用
Veena K Parnaik
Veena K Parnaik
Lamins are the major architectural proteins of the nucleus and are essential for nuclear integrity and assembly. Lamins are also involved in the organization of nuclear functions such as DNA replication, transcription, and repair. Mutations...
Plasmodium in the postgenomic era: new insights into the molecular cell biology of malaria parasites [0.03%]
基因组学研究后的疟原虫：对疟疾 parasite 分子细胞生物学的新见解
Celia R S Garcia,Mauro F de Azevedo,Gerhard Wunderlich et al.
Celia R S Garcia et al.
In this review, we bring together some of the approaches toward understanding the cellular and molecular biology of Plasmodium species and their interaction with their host red blood cells. Considerable impetus has come from the development...
Ichiro Mine,Diedrik Menzel,Kazuo Okuda
Ichiro Mine
The giant-celled algae, which consist of cells reaching millimeters in size, some even centimeters, exhibit unique cell architecture and physiological characteristics. Their cells display a variety of morphogenetic phenomena, that is, growt...
Domenico Ribatti
Domenico Ribatti
The development of transgenic technologies in mice has allowed the study of the consequences of genetic alterations on angiogenesis and lymphangiogenesis. This review summarizes the murine models currently available for studies involving th...
Identification of cell-free circulating epigenomic biomarkers for early diagnosis and response to therapies in breast cancer patients [0.03%]
鉴定乳腺癌患者无细胞循环表观基因组生物标志物以实现早期诊断和治疗反应监测
The increasing prevalence of breast cancer presents a significant global health challenge, highlighting the urgent need for improved diagnostic and treatment monitoring methods. The non-invasive nature of cell-free circulating epigenomic bi...