Circuits involving the hypothalamic suprachiasmatic nucleus for controlling diverse physiologies verified by the aid of optogenetics and chemogenetics [0.03%]
利用光遗传学和化学遗传学验证下丘脑视交叉上核相关通路对多种生理功能调控作用的电路研究
Sui-Wen Hsiao,Masao Doi
Sui-Wen Hsiao
The suprachiasmatic nucleus (SCN) functions as the master circadian pacemaker in mammals. Since 2015, facilitated by cutting-edge optogenetic and chemogenetic techniques, significant progress has been made in understanding the circuits invo...
Multi-omic features and clustering phenotypes of circulating tumor cells associated with metastasis and clinical outcomes [0.03%]
与转移和临床结局相关的循环肿瘤细胞的多组学特征及聚类表型
Anmol Singh,Huiping Liu,Lamiaa El-Shennawy
Anmol Singh
Metastasis is a lethal disease of cancer, spreading from primary tumors to the bloodstream as circulating tumor cells (CTCs), which disseminate to distant organs at low efficiency for secondary tumor regeneration, thereby contributing to un...
Epigenetics and CTCs: New biomarkers and impact on tumor biology [0.03%]
表观遗传学和CTCs：新的生物标志物及其对肿瘤生物学的影响
Aliki Ntzifa,Evi Lianidou
Aliki Ntzifa
DNA methylation is one of the best-known epigenetic markers and plays a critical role in the control of gene activity and the architecture of the nucleus of the cell. Epigenetic alterations and especially DNA methylation have a high potenti...
Advances in metastatic prostate cancer circulating tumor cell enrichment technologies and clinical studies [0.03%]
前列腺癌循环肿瘤细胞捕获与富集技术的临床应用进展
Naira Essam Abou-Ghali,Paraskevi Giannakakou
Naira Essam Abou-Ghali
Circulating tumor cells (CTCs) have emerged as a pivotal tool that enables molecular interrogation of patient tumor cells and association with clinical outcomes. In prostate cancer specifically, where tumor biopsies from patients with bone ...
Youbin Zhang,David Scholten,Wenan Qiang et al.
Youbin Zhang et al.
During cancer metastasis, tumor cells migrate from the primary tumor site and spread to distant tissue or organs through the circulatory system of the body. While it is challenging to track metastatic tumor cells, circulating tumor cells (C...
Areeb Lutfi,Maaz Khan Afghan,Pashtoon Murtaza Kasi
Areeb Lutfi
Liquid biopsy, which includes both circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) has become a valuable tool for cancer diagnosis and monitoring. It offers a less invasive approach than traditional tissue biopsy and recent...
Circulating tumor cells in lung cancer: Integrating stemness and heterogeneity to improve clinical utility [0.03%]
肺癌循环肿瘤细胞的研究进展：整合干细胞特性及异质性以提高临床应用价值
Teresa Beninato,Giuseppe Lo Russo,Rita Leporati et al.
Teresa Beninato et al.
Circulating tumor cells (CTC), released by primary tumors into the bloodstream, represent a valuable source to inform on cancer heterogeneity, cancer progression, metastatic disease and therapy efficacy without the need of invasive tumor bi...
Circulating biomarkers for diagnosis, prognosis, and treatment response prediction in cancer [0.03%]
癌症诊断、预后及治疗反应预测的循环生物标志物
Lorenzo Galluzzi,Sheila Spada
Lorenzo Galluzzi
Identification of circulating tumor DNA as a biomarker for diagnosis and response to therapies in cancer patients [0.03%]
循环肿瘤DNA作为癌症患者诊断和治疗反应生物标志物的鉴定
Ronan W Hsieh,Lynn K Symonds,Jason Siu et al.
Ronan W Hsieh et al.
The sampling of circulating biomarkers provides an opportunity for non-invasive evaluation and monitoring of cancer activity. In modern day practice, this has typically been in the form of circulating tumor DNA (ctDNA) detected in plasma. T...
Nectin-4: A promising prognostic marker and therapeutic target in cancer [0.03%]
nectin-4：癌症预后的新标志物和治疗靶点
Shilpa Kuttikrishnan,Kirti S Prabhu,Ummu Habeeba et al.
Shilpa Kuttikrishnan et al.
Nectin cell adhesion protein 4 (Nectin-4), a calcium-independent immunoglobulin-like protein, has garnered significant attention in oncology due to its pronounced overexpression in malignant tumors and absence in healthy adult tissues. Elev...