Richa Singh,Anindita Ray
Richa Singh
In this chapter, we have made an attempt to elucidate the relevance of hedgehog signaling pathway in tumorigenesis. Here, we have described different types of hedgehog signaling (canonical and non-canonical) with emphasis on the different m...
Mitochondria driven innate immune signaling and inflammation in cancer growth, immune evasion, and therapeutic resistance [0.03%]
线粒体驱动的先天免疫信号通路及炎症在肿瘤生长、免疫逃逸和治疗抵抗中的作用
Sanjay Pandey,Vandana Anang,Michelle M Schumacher
Sanjay Pandey
Mitochondria play an important and multifaceted role in cellular function, catering to the cell's energy and biosynthetic requirements. They modulate apoptosis while responding to diverse extracellular and intracellular stresses including r...
Targeting KRAS and SHP2 signaling pathways for immunomodulation and improving treatment outcomes in solid tumors [0.03%]
靶向KRAS和SHP2信号通路进行免疫调节及改善实体瘤治疗效果
Priyanka Sahu,Ankita Mitra,Anirban Ganguly
Priyanka Sahu
Historically, KRAS has been considered 'undruggable' inspite of being one of the most frequently altered oncogenic proteins in solid tumors, primarily due to the paucity of pharmacologically 'druggable' pockets within the mutant isoforms. H...
The crosstalk between miRNAs and signaling pathways in human cancers: Potential therapeutic implications [0.03%]
人类癌症中miRNA与信号通路的串扰及其潜在治疗意义
Ritu Shekhar,Sujata Kumari,Satyam Vergish et al.
Ritu Shekhar et al.
MicroRNAs (miRNAs) are increasingly recognized as central players in the regulation of eukaryotic physiological processes. These small double stranded RNA molecules have emerged as pivotal regulators in the intricate network of cellular sig...
Cellular signaling in glioblastoma: A molecular and clinical perspective [0.03%]
胶质母细胞瘤中的细胞信号转导：分子与临床观点
Debarati Ghosh,Brett Pryor,Nancy Jiang
Debarati Ghosh
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with an average life expectancy of less than 15 months. Such high patient mortality in GBM is pertaining to the presence of clinical and molecular heterogeneity attributed to ...
Emerging trends in gastrointestinal cancers: Targeting developmental pathways in carcinogenesis and tumor progression [0.03%]
胃肠肿瘤研究新趋势——靶向发育途径探讨肿瘤发生及发展的分子机制
Afza Ahmad,Rohit Kumar Tiwari,Saleha Siddiqui et al.
Afza Ahmad et al.
Gastrointestinal carcinomas are a group of cancers associated with the digestive system and its accessory organs. The most prevalent cancers related to the gastrointestinal tract are colorectal, gall bladder, gastric, hepatocellular, and es...
Exploring TLR signaling pathways as promising targets in cervical cancer: The road less traveled [0.03%]
探索TLR信号途径在宫颈癌中的作用及其作为治疗靶点的潜力
Mohini Agarwal,Manish Kumar,Rajiv Pathak et al.
Mohini Agarwal et al.
Cervical cancer is the leading cause of cancer-related deaths for women globally. Despite notable advancements in prevention and treatment, the identification of novel therapeutic targets remains crucial for cervical cancer. Toll-like recep...
Factors affecting heterogeneity in breast cancer microenvironment: A narrative mini review [0.03%]
影响乳腺肿瘤微环境异质性的因素：述评性短文
Anirban Ganguly,Sumit Mukherjee,Kaushiki Chatterjee et al.
Anirban Ganguly et al.
Breast cancer (BC) heterogeneity is a key trait of BC tumors with crucial implications on tumorigenesis, diagnosis, and therapeutic modalities. It is influenced by tumor intrinsic features and by the tumor microenvironment (TME) composition...
Targeting signaling pathways in cancer stem cells: A potential approach for developing novel anti-cancer therapeutics [0.03%]
针对癌症干细胞信号转导通路的治疗：开发新型抗癌药物的新思路
Saptarshi Sinha,Krushna Chandra Hembram,Subhajit Chatterjee
Saptarshi Sinha
Cancer stem cells (CSCs) have emerged as prime players in the intricate landscape of cancer development, progression, and resistance to traditional treatments. These unique cellular subpopulations own the remarkable capability of self-renew...
Importance of targeting various cell signaling pathways in solid cancers [0.03%]
实体瘤中针对各种细胞信号通路靶向的重要意义分析
Chandrayee Ghosh,Jiangnan Hu
Chandrayee Ghosh
Most adult human cancers are solid tumors prevailing in vital organs and lead to mortality all over the globe. Genetic and epigenetic alterations in cancer genes or genes of associated signaling pathways impart the most common characteristi...