Chemokine receptors and their ligands in breast cancer: The key roles in progression and metastasis [0.03%]
乳腺癌中的趋化因子受体及其配体在进展和转移中的关键作用
Julio Valdivia-Silva,Alberto Chinney-Herrera
Julio Valdivia-Silva
Chemokines and their receptors are a family of chemotactic cytokines with important functions in the immune response in both health and disease. Their known physiological roles such as the regulation of leukocyte trafficking and the develop...
Hector Cordero
Hector Cordero
Chemokine receptors are a complex superfamily of surface G protein-coupled receptors present mostly in leukocytes. In this chapter, we review the presence and functions of chemokine receptors in the immune cells of the primary and secondary...
Sheila Spada,Lorenzo Galluzzi
Sheila Spada
Epigenetic orchestration of the DNA damage response: Insights into the regulatory mechanisms [0.03%]
表观遗传学调控的DNA损伤应答：关于调控机制的见解
Atanu Mondal,Agniswar Sarkar,Dipanwita Das et al.
Atanu Mondal et al.
The DNA damage response (DDR) is a critical cellular mechanism that safeguards genome integrity and prevents the accumulation of harmful DNA lesions. Increasing evidence highlights the intersection between DDR signaling and epigenetic regul...
Hue Vu Thi,Anh-Dao Ngo,Dinh-Toi Chu
Hue Vu Thi
Ovarian cancer is one of the diseases that have the highest mortality rate for women, especially women over 50 years old. In the future, incidence and mortality rates are predicted to extend in countries with low HDI. Instability in the str...
Epigenetic alterations in AML: Deregulated functions leading to new therapeutic options [0.03%]
急性髓系白血病中的表观遗传改变：功能失调及新的治疗选择
Kourosh Hayatigolkhatmi,Riccardo Valzelli,Oualid El Menna et al.
Kourosh Hayatigolkhatmi et al.
Acute myeloid leukemia (AML) results in disruption of the hematopoietic differentiation process. Crucial progress has been made, and new therapeutic strategies for AML have been developed. Induction chemotherapy, however, remains the main o...
Yen-Vy Nguyen Thi,Thuy-Duong Vu,Nguyen Thi Lan Huong et al.
Yen-Vy Nguyen Thi et al.
Obesity and cancer are two major health issues all around the world due to their elevated prevalence. Several experimental and epidemiological studies have demonstrated the relationship between obesity and cancer, in which obesity is consid...
Epigenetic contributions to cancer: Exploring the role of glycation reactions [0.03%]
糖基化反应在癌症表观遗传中的作用探索
Hamda Khan,Zeeshan Rafi,Mohd Yasir Khan et al.
Hamda Khan et al.
Advanced Glycation End-products (AGEs), with their prolonged half-life in the human body, are emerging as potent diagnostic indicators. Early intervention studies, focusing on AGE cross-link breakers, have shown encouraging results in heart...
Songhua Quan,Hao Huang
Songhua Quan
Epigenetics has transformed our understanding of cancer by revealing how changes in gene activity, which do not alter the DNA itself, can initiate and progress the disease. These changes include adjustments in DNA methylation, histone confi...
An Overview of the Unfolded Protein Response (UPR) and Autophagy Pathways in Human Viral Oncogenesis [0.03%]
人类病毒致癌中未折叠蛋白反应（UPR）和自噬途径概述
Shovan Dutta,Anirban Ganguly,Sounak Ghosh Roy
Shovan Dutta
Autophagy and Unfolded Protein Response (UPR) can be regarded as the safe keepers of cells exposed to intense stress. Autophagy maintains cellular homeostasis, ensuring the removal of foreign particles and misfolded macromolecules from the ...