Unravelling the molecular basis of PARP inhibitor resistance in prostate cancer with homologous recombination repair deficiency [0.03%]
解开同源重组修复缺陷型前列腺癌耐药的分子机制
Nabila Zaman,Atar Singh Kushwah,Anagha Badriprasad et al.
Nabila Zaman et al.
Prostate cancer is a disease with heterogeneous characteristics, making its treatability and curability dependent on the cancer's stage. While prostate cancer is often indolent, some cases can be aggressive and evolve into metastatic castra...
Subhajit Chatterjee,Prarthana Prashanth,Vipin Rawat et al.
Subhajit Chatterjee et al.
Tumor formation is supported by metabolic reprogramming, characterized by increase nutrient uptake, glycolysis and glutaminolysis. The c-Myc proto-oncogene is a transcription factor, upregulated in most cancers and several reports showed th...
Immunological landscape of solid cancer: Interplay between tumor and autoimmunity [0.03%]
实体肿瘤的免疫图谱：肿瘤与自身免疫之间的相互作用
Ajay K Singh,Phaneendra K Duddempudi,Divya Borasandra Kenchappa et al.
Ajay K Singh et al.
The immune system, a central player in maintaining homeostasis, emerges as a pivotal factor in the pathogenesis and progression of two seemingly disparate yet interconnected categories of diseases: autoimmunity and cancer. This chapter delv...
Role of interferon dependent and independent signaling pathways: Implications in cancer [0.03%]
干扰素依赖和非干扰素信号转导通路在癌症中的作用及其意义
Sheila Spada,Anirban Ganguly
Sheila Spada
Interferons (IFNs) are a class of cytokines with potent antiviral and immunomodulatory properties that regulate the immune system through multiple signaling pathways. In cancer, IFNs are vital to both tumor-intrinsic and extrinsic mechanism...
DNA damage response and neoantigens: A favorable target for triple-negative breast cancer immunotherapy and vaccine development [0.03%]
DNA损伤反应与新抗原：用于开发三阴性乳腺癌免疫治疗和疫苗的有利靶点
Rajasekaran Subbarayan,Dhasarathdev Srinivasan,Ranjith Balakrishnan et al.
Rajasekaran Subbarayan et al.
Triple-negative breast cancer (TNBC) poses a significant clinical challenge due to its aggressive nature and limited therapeutic options. The interplay between DNA damage response (DDR) mechanisms and the emergence of neoantigens represents...
Abhishek Bhattacharya,Anjan Kr Dasgupta
Abhishek Bhattacharya
Solid tumors are the most prevalent form of cancer. Considerable technological and medical advancements had been achieved for the diagnosis of the disease. However, detection of the disease in an early stage is of utmost importance, still f...
Role of chemokine receptors in transplant rejection and graft-versus-host disease [0.03%]
趋化因子受体在移植排斥和移植物抗宿主病中的作用
Paula Alonso-Guallart,David Harle
Paula Alonso-Guallart
Organ transplantation increases life expectancy and improves the quality of life of patients experiencing specific conditions such as terminal organ failure. Despite matching efforts between donor and recipient, immune activation can interf...
Claudia Gutierrez-Chavez,Shalom Aperrigue-Lira,Brando Ortiz-Saavedra et al.
Claudia Gutierrez-Chavez et al.
Chemokine receptors play diverse roles in the immune response against pathogens by recruiting innate and adaptive immune cells to sites of infection. However, their involvement could also be detrimental, causing tissue damage and exacerbati...
Brett Bell,Kevin Flores-Lovon,Luis A Cueva-Chicaña et al.
Brett Bell et al.
Chemokine receptors are essential for the immune response in the oral and gut mucosa. The gastrointestinal mucosa is characterized by the presence of immune populations because it is susceptible to inflammatory and infectious diseases, nece...
Chemotactic signaling pathways in prostate cancer: Implications in the tumor microenvironment and as potential therapeutic targets [0.03%]
前列腺癌中的趋化信号通路：在肿瘤微环境及潜在治疗靶标方面的意义
Zoila A Lopez-Bujanda,Shawn H Hadavi,Vicenç Ruiz De Porras et al.
Zoila A Lopez-Bujanda et al.
Prostate cancer (PCa) stands as a significant global health concern, ranking among the leading causes of cancer deaths in men. While there are several treatment modalities for localized PCa, metastatic castration-resistant PCa (mCRPC) remai...