Unraveling the role of γδ T cells in inflammatory bowel disease: Development and prevention strategies [0.03%]
γδ T细胞在炎症性肠病中的作用及防治策略研究进展
Ana María Múnera-Rodríguez,Camila Leiva-Castro,Pedro Chacón et al.
Ana María Múnera-Rodríguez et al.
Inflammatory bowel diseases (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), are autoimmune disorders characterized by heterogeneous clinical manifestations and dysregulated immune responses. Central to this pathophysio...
Jiayu Peng,Hui Qiu,Lin-Lin Bu et al.
Jiayu Peng et al.
Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive malignant tumor with poor clinical prognosis. The immune system plays a critical role in tumor surveillance and response to therapy. Among various immune cell popul...
The antiviral potential of Vγ9Vδ2 T cells: Therapeutic implications for immunocompromised adult and pediatric hosts [0.03%]
Vγ9Vδ2 T细胞的抗病毒潜力：免疫抑制成人和儿童患者治疗的意义
Veronica Bordoni,Federica Guarracino,Angela Lorusso et al.
Veronica Bordoni et al.
A growing number of pediatric and adult subjects worldwide suffer from impaired immune response to pathogens, due to both disease and medical treatments. Different types of immunodeficiency or immunosuppressive drugs may affect different as...
Gamma delta T cells: Multifaceted mediators in pregnancy and the pathogenesis of miscarriage [0.03%]
伽玛Delta T细胞：在妊娠及流产发病机制中的多面体调解因素
Qianhan Xu,Lu Chen,Junshang Dai et al.
Qianhan Xu et al.
Pregnancy represents a unique physiological process characterized by a delicate balance between immune tolerance and immune surveillance. Gamma delta (γδ) T cells, serving as a bridge between adaptive and innate immunity, play crucial rol...
Shiyu Wang,Xin Lu
Shiyu Wang
γδ T cells are a distinct subset of T lymphocytes that recognize and attack cancer cells without needing major histocompatibility complex molecules, making them particularly useful against tumors that evade conventional immune detection. ...
The key role of immunomodulatory cytokines for the development of novel NK cell-based cancer therapies [0.03%]
免疫调节细胞因子在新型NK细胞为基础的癌症治疗中的关键作用
Andrea Saez de Cámara,Diego Barriales,Anne Etxebarria et al.
Andrea Saez de Cámara et al.
Cytokines are crucial modulators of immune responses and have emerged as key components in cancer immunotherapy, particularly concerning Natural Killer (NK) cells. Indeed, the administration of these cytokines have demonstrated significant ...
Targeting TNF-α: An immunotherapeutic approach for alleviating neuropathic pain [0.03%]
靶向TNF-α：一种用于缓解神经病理性疼痛的免疫治疗方法
Mario García-Domínguez
Mario García-Domínguez
Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a key role in regulating immune responses. It is primarily produced by activated macrophages but also by other cell types, including T lymphocytes and natural kil...
Mário Sousa-Pimenta,Nuno R Dos Santos
Mário Sousa-Pimenta
Cytokines regulate both innate and adaptive immunity, thus bridging these two types of immune response. Initially explored as standalone cancer therapies, their use was hindered by the unfavorable pharmacokinetic profiles of recombinant mol...
Aline Risson,Leire Arrizabalaga,Miriam Ezcurra-Hualde et al.
Aline Risson et al.
IL-27, a cytokine with pleiotropic immunomodulatory functions, has garnered increasing attention in the context of tumor immunity, and its role in the tumor microenvironment (TME) is complex and just beginning to unravel. IL-27 is pivotal i...
Clinical development complexity of TGF-β inhibition: From fibrosis to cancer immunotherapy [0.03%]
转化生长因子β抑制的临床研发复杂性：从纤维化到癌症免疫治疗
Gabriel Gallo-Oller,María Isabel Guillén-Antonini,Javier Dotor
Gabriel Gallo-Oller
More than four decades have passed since the discovery of Transforming Growth Factor beta (TGF-β) in 1981, a pivotal cytokine with profound implications in cell biology and potential clinical interventions for physio-pathological processes...