Lorenzo Galluzzi,Sheila Spada
Lorenzo Galluzzi
DOGMA-seq and multimodal, single-cell analysis in acute myeloid leukemia [0.03%]
单细胞DOGMASEQ和多模态急性髓系白血病分析法
JangKeun Kim,Nathan Schanzer,Ruth Subhash Singh et al.
JangKeun Kim et al.
Acute myeloid leukemia (AML) is a complex cancer, yet advances in recent years from integrated genomics methods have helped improve diagnosis, treatment, and means of patient stratification. A recent example of a powerful, multimodal method...
Elisa-Elvira Figueroa-Angulo,Jonathan Puente-Rivera,Yussel Fernando Perez-Navarro et al.
Elisa-Elvira Figueroa-Angulo et al.
The critical role of a subset of Human Papillomavirus in cervical cancer has been widely acknowledged and studied. Despite progress in our understanding of the viral molecular mechanisms of pathogenesis, knowledge of how infection with HPV ...
Epigenetic modulation of doxorubicin resistance and strategies for enhancing chemotherapeutic sensitivity [0.03%]
表观遗传调控多柔比星耐药及增强化疗敏感性的策略研究进展
Sruthi Sritharan,Nageswaran Sivalingam
Sruthi Sritharan
With the rising global cancer burden, the dependency on chemotherapy also rises along with the complication of chemoresistance development. Studies on multi-drug resistant proteins provide a wide range of regulators, although the exact mech...
The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer [0.03%]
表观遗传调控活性植物化学物质作为癌症辅助治疗的转化潜力
Priya Mondal,Gowthami Jayaprakash,Syed Musthapa Meeran
Priya Mondal
In preclinical studies, bioactive phytochemicals have shown enormous potential therapeutic efficacy against various human malignancies. These natural compounds have been shown to possess an inherent potential to alter the molecular signalin...
Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity [0.03%]
微小核糖核酸在肺癌免疫中作为免疫检查点表观遗传调控因子的作用
Irene Cánovas-Cervera,Elena Nacher-Sendra,Guillermo Suay et al.
Irene Cánovas-Cervera et al.
The advent of immunotherapy in cancer has provided new avenues in the treatment of many malignancies at various stages. Specifically, immune checkpoint inhibitors (ICIs) have transformed the field of lung cancer treatment. However, since so...
Revisiting epigenetic regulation in cancer: Evolving trends and translational implications [0.03%]
癌症表观遗传调控的再思考：发展趋势与转化意义
Mohammad Afsar Khan,Dhruv Mishra,Ranjan Kumar et al.
Mohammad Afsar Khan et al.
Cancer is a leading cause of mortality worldwide. The evolving role of epigenetics and tumor microenvironments of cancer pose significant challenges to the management of cancer. Besides genetics, epigenetic changes play a crucial role in th...
Sheila Spada,Lorenzo Galluzzi
Sheila Spada
Sheila Spada,Lorenzo Galluzzi
Sheila Spada
Tumor microenvironment induced switch to mitochondrial metabolism promotes suppressive functions in immune cells [0.03%]
肿瘤微环境诱导的线粒体代谢转换促进免疫细胞抑制功能
Sanjay Pandey,Vandana Anang,Michelle M Schumacher
Sanjay Pandey
Understanding the intricacies of the metabolic phenotype in immune cells and its plasticity within the tumor microenvironment is pivotal in understanding the pathology and prognosis of cancer. Unfavorable conditions and cellular stress in t...