Prachi Agrawal,Prachi Mendhey,Robins Kumar et al.
Prachi Agrawal et al.
The human microbiome is a complex ecological system of commensal, symbiotic, and pathogenic microorganisms that plays a crucial role in human health and disease. The microbiome includes both the living microorganisms also called microbiota ...
Christopher Litwin,Kevin B Koronowski
Christopher Litwin
Over the course of a day, the circadian clock promotes a homeostatic balance between energy intake and energy expenditure by aligning metabolism with nutrient availability. In mammals, this process is driven by central clocks in the brain t...
Emerging interactions between circadian rhythms and extracellular vesicles [0.03%]
circadian节律和细胞外囊泡之间的新兴相互作用
Jacob G Smith
Jacob G Smith
Circadian rhythms are present across species, tuning internal processes to daily changes in the environment. Driven by genetically encoded circadian clocks present throughout the body, and modulated by external inputs, the circadian system ...
Jeffrey J Kelu
Jeffrey J Kelu
All major life forms from bacteria to humans have internal clocks that regulate essential biological processes in a roughly 24-h cycle. In mammals, the central clock in the suprachiasmatic nucleus (SCN) is historically considered the top of...
Rosanna Caputo,Alessandra Idini,Carolina Magdalen Greco
Rosanna Caputo
Virtually every cell in the human body contains a molecular circadian clock that orchestrates the rhythmic oscillations of a multitude of tissue-specific functions. This is evident in the heart, where circadian rhythms are seen in various c...
Non-rhythmic modulators of the circadian system: A new class of circadian modulators [0.03%]
非节律性昼夜调节因子：一种新的昼夜调节因子类型
Leonardo Vinícius Monteiro de Assis,Henrik Oster
Leonardo Vinícius Monteiro de Assis
The temporal organization of biological processes is critical for an organism's fitness and survival. An internal circadian clock network coordinates the alignment between the external and internal milieus via an array of systemic factors c...
Circuits involving the hypothalamic suprachiasmatic nucleus for controlling diverse physiologies verified by the aid of optogenetics and chemogenetics [0.03%]
利用光遗传学和化学遗传学验证下丘脑视交叉上核相关通路对多种生理功能调控作用的电路研究
Sui-Wen Hsiao,Masao Doi
Sui-Wen Hsiao
The suprachiasmatic nucleus (SCN) functions as the master circadian pacemaker in mammals. Since 2015, facilitated by cutting-edge optogenetic and chemogenetic techniques, significant progress has been made in understanding the circuits invo...
Multi-omic features and clustering phenotypes of circulating tumor cells associated with metastasis and clinical outcomes [0.03%]
与转移和临床结局相关的循环肿瘤细胞的多组学特征及聚类表型
Anmol Singh,Huiping Liu,Lamiaa El-Shennawy
Anmol Singh
Metastasis is a lethal disease of cancer, spreading from primary tumors to the bloodstream as circulating tumor cells (CTCs), which disseminate to distant organs at low efficiency for secondary tumor regeneration, thereby contributing to un...
Epigenetics and CTCs: New biomarkers and impact on tumor biology [0.03%]
表观遗传学和CTCs：新的生物标志物及其对肿瘤生物学的影响
Aliki Ntzifa,Evi Lianidou
Aliki Ntzifa
DNA methylation is one of the best-known epigenetic markers and plays a critical role in the control of gene activity and the architecture of the nucleus of the cell. Epigenetic alterations and especially DNA methylation have a high potenti...