J Constanzo,Y Bouden,L Godry et al.
J Constanzo et al.
It is now clear that conventional radiation therapy can reinstate cell death immunogenicity. Recent preclinical data indicate that targeted radionuclide therapy that irradiate tumors at continuous low dose rate also can elicit immunostimula...
François de Kermenguy,Lydia Meziani,Michele Mondini et al.
François de Kermenguy et al.
Radiation-induced lymphopenia (RIL) is characterized by a significant decrease in the absolute number of lymphocytes circulating in the blood after radiotherapy. With the major shift in cancer management initiated by cancer immunotherapy (I...
Krishnaveni Mohareer,Sharmistha Banerjee
Krishnaveni Mohareer
The ability of Mycobacterium tuberculosis (M. tb) to hijack host mitochondria and control host immune signaling is the key to its successful infection. Infection of M. tb causes distinct changes in mitochondrial morphology, metabolism, disr...
Attaching and effacing pathogens modulate host mitochondrial structure and function [0.03%]
附着溶解病原体调节宿主线粒体的结构和功能
Anusha Harishankar,V K Viswanathan
Anusha Harishankar
Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) are human enteric pathogens that contribute significantly to morbidity and mortality worldwide. These extracellular pathogens attach intimately to intestinal epithelial...
Bacterial and mammalian F1FO-ATPase: Structural similarities and divergences to exploit in the battle against Mycobacterium tuberculosis [0.03%]
结核分枝杆菌菌株F1FO-ATP酶与哺乳动物F1FO-ATP酶的结构异同点及其应用价值
Salvatore Nesci
Salvatore Nesci
The inner mitochondrial membrane, thylakoid membrane of chloroplasts and bacterial plasma membrane play a central role in energy transduction processes exploiting a ubiquitous membrane-bound enzyme complex known as F1FO-ATPase. The enzyme m...
Control of mitochondrial functions by Pseudomonas aeruginosa in cystic fibrosis [0.03%]
铜绿假单胞菌对囊性纤维化中线粒体功能的调控作用
Giulia Pellielo,Esther Densu Agyapong,Paolo Pinton et al.
Giulia Pellielo et al.
Cystic fibrosis (CF) is a genetic disease characterized by mutations of cystic fibrosis transmembrane conductance regulator (CFTR) gene, which lead to a dysfunctional chloride and bicarbonate channel. Abnormal mucus viscosity, persistent in...
Gloria D&#x;Achille,Gianluca Morroni
Gloria D&#x;Achille
Antibiotics are one of the greatest discoveries of medicine of the past century. Despite their invaluable contribution to infectious disease, their administration could lead to side effects that in some cases are serious. The toxicity of so...
Kai Qi Yek,Diana Stojanovski,Hayley J Newton
Kai Qi Yek
In order to successfully establish a replicative niche, intracellular bacterial pathogens must influence eukaryotic cell biology. Vesicle and protein traffic, transcription and translation, metabolism and innate immune signaling are all imp...
The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview [0.03%]
巨噬细胞的多种功能和表型也体现在其对辐照的反应中——现状概述
Lisa Deloch,Michael Rückert,Thomas Weissmann et al.
Lisa Deloch et al.
Macrophages are a vital part of the innate immune system that are involved in healthy biological processes but also in disease modulation and response to therapy. Ionizing radiation is commonly used in the treatment of cancer and, in a lowe...
Cyrus Chargari,Elie Rassy,Carole Helissey et al.
Cyrus Chargari et al.
Radiation therapy has a fundamental role in the management of cancers. However, despite a constant improvement in radiotherapy techniques, the issue of radiation-induced side effects remains clinically relevant. Mechanisms of acute toxicity...