Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer [0.03%]
针对树突状细胞的免疫检查点以抗体为基础的癌症调节方法
Xin Lei,Yizhi Wang,Chayenne Broens et al.
Xin Lei et al.
Dendritic cells (DC) are professional antigen-presenting cells which link innate to adaptive immunity. DC play a central role in regulating antitumor T-cell responses in both tumor-draining lymph nodes (TDLN) and the tumor microenvironment ...
Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment [0.03%]
用于研究肿瘤微环境的下一代转录组数据分离技术
Lorenzo Merotto,Maria Zopoglou,Constantin Zackl et al.
Lorenzo Merotto et al.
Methods for in silico deconvolution of bulk transcriptomics can characterize the cellular composition of the tumor microenvironment, quantifying the abundance of cell types associated with patients' prognosis and response to therapy. While ...
Robin Maximilian Awad,Karine Breckpot
Robin Maximilian Awad
Cancer cells develop several ways to subdue the immune system among others via upregulation of inhibitory immune checkpoint (ICP) proteins. These ICPs paralyze immune effector cells and thereby enable unfettered tumor growth. Monoclonal ant...
Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis [0.03%]
破解非典型循环肿瘤细胞的不确定性：上皮间质转化、细胞融合和交叉吞噬作用
Giulia Gallerani,Tania Rossi,Manuela Ferracin et al.
Giulia Gallerani et al.
Circulating tumor cells (CTCs) were first described 150 years ago. The so-called "classical" CTC populations (EpCAM+/CK+/CD45-) have been fully characterized and proposed as the most representative CTC subset, with clinical relevance. Nonet...
Cristóbal Fernández-Santiago,Rafael López-López,Roberto Piñeiro
Cristóbal Fernández-Santiago
The vast majority of cancer-related deaths are due to the presence of disseminated disease. Understanding the metastatic process is key to achieving a reduction in cancer mortality. Particularly, there is a need to understand the molecular ...
Serena Di Cosimo,Cinzia De Marco,Marco Silvestri et al.
Serena Di Cosimo et al.
Human Epidermal growth factor Receptor 2 (HER2) assessment is crucial for breast cancer treatment. Therapeutic decisions for recurrent cases often rely on primary tumor status. However, mounting evidence suggests that tumors show dynamic ch...
Elena Muraro,Giulia Brisotto
Elena Muraro
During their dissemination, circulating tumor cells (CTCs) steadily face the immune system, which is a key player in the whole metastatic cascade, from intravasation to the CTC colonization of distant sites. In this chapter, we will go thro...
Circulating tumor cells in cancer-risk populations as a cancer interception tool [0.03%]
循环肿瘤细胞作为癌症拦截工具在癌症风险人群中的作用
María José Serrano,Christian Rolfo,José Expósito-Hernandez et al.
María José Serrano et al.
Cancer interception (CI) is a new approach to cancer prevention and treatment in a cancer-risk population that aims to detect and treat pre-tumoral stages. It has several potential advantages over traditional cancer diagnosis and monitoring...
Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer [0.03%]
早期和转移性乳腺癌循环肿瘤细胞临床研究的新进展
Laura S Munoz-Arcos,Eleonora Nicolò,Mara S Serafini et al.
Laura S Munoz-Arcos et al.
Circulating tumor cells (CTCs) have emerged as a promising biomarker in breast cancer, offering insights into disease progression and treatment response. While CTCs have demonstrated prognostic relevance in early breast cancer, more validat...
Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites [0.03%]
癌症中的超级增强子景观重塑：远端位点的表观遗传调控
Eros Di Giorgio,Roberta Benetti,Emanuela Kerschbamer et al.
Eros Di Giorgio et al.
Super-enhancers evolve as elements at the top of the hierarchical control of gene expression. They are important end-gatherers of signaling pathways that control stemness, differentiation or adaptive responses. Many epigenetic regulations f...