Drugging the undruggable: Advances in targeting KRAS signaling in solid tumors [0.03%]
攻克“不可成药”靶点：KRAS信号转导在实体瘤中的进展
Prajna Tripathi,Rajni Kumari,Rajiv Pathak
Prajna Tripathi
Cancer remains the leading cause of global mortality, prompting a paradigm shift in its treatment and outcomes with the advent of targeted therapies. Among the most prevalent mutations in RAS-driven cancers, Kirsten rat sarcoma viral oncoge...
Maroua Manai,Hamouda Boussen,Massimo Cristofanilli
Maroua Manai
Deciphering the molecular biology of inflammatory breast cancer through molecular characterization of patient samples and preclinical models [0.03%]
通过患者样本和临床前模型的分子特征分析解读炎性乳腺癌的分子生物学特性
Charlotte Rypens,Christophe Van Berckelaer,Fedor Berditchevski et al.
Charlotte Rypens et al.
Inflammatory breast cancer is an aggressive subtype of breast cancer with dismal patient prognosis and a unique clinical presentation. In the past two decades, molecular profiling technologies have been used in order to gain insight into th...
Kenneth L van Golen
Kenneth L van Golen
Inflammatory breast cancer (IBC) is a unique breast cancer with a highly virulent course and low 5- and 10-year survival rates. Even though it only accounts for 1-5% of breast cancers it is estimated to account for 10% of breast cancer deat...
Inflammatory breast cancer: An overview about the histo-pathological aspect and diagnosis [0.03%]
炎性乳腺癌：关于组织病理学方面和诊断的概述
Ghada Sahraoui,Nabil Rahoui,Maha Driss et al.
Ghada Sahraoui et al.
Inflammatory Breast Cancer (IBC) is a rare and aggressive form of locally advanced breast cancer, classified as stage T4d according to the tumor-node-metastasis staging criteria. This subtype of breast cancer is known for its rapid progress...
Michael C Stauder
Michael C Stauder
Inflammatory breast cancer (IBC) is a diagnosis based on a constellation of clinical features of edema (peau d'orange) of a third or more of the skin of the breast with a palpable border and a rapid onset of breast erythema. Incidence of IB...
Inflammatory breast cancer (IBC) advocacy-Past, present and future! [0.03%]
炎症性乳腺癌(IBC)的倡导工作——过去、现在和未来！
Jeannine Donahue,Joshlyn Earls,Valerie Fraser et al.
Jeannine Donahue et al.
Patient advocates, referring to those individuals that have been diagnosed with the disease for which they advocate, are essential stake holders in healthcare. For those facing the stages of being diagnosed with Inflammatory Breast Cancer (...
Toshiaki Iwase,Xiaoping Wang,Lan Thi Hanh Phi et al.
Toshiaki Iwase et al.
Hatem Bouzaiene,Fatma Saadallah,Hanen Bouaziz et al.
Hatem Bouzaiene et al.
Breast cancer surgery is the primary treatment for early-stage breast cancer. However, inflammatory breast cancer (IBC), with its specific presentation characterized by skin invasion, is unfit for primary surgery. According to the different...
Hamouda Boussen,Yosra Berrazaga,Sherif Kullab et al.
Hamouda Boussen et al.
Since the early description more than a century ago, inflammatory breast cancer (IBC) remains an aggressive disease, with a different geographic repartition, with the highest ones incidence reported in the North of Africa (Tunisia, Algeria,...