Interleukin 10: Bridging the chasms in the immune landscape of multiple myeloma [0.03%]
interleukin 10：弥合多发性骨髓瘤免疫景观的鸿沟
Queenie Fernandes,Abdul W Ansari,Karama Makni-Maalej et al.
Queenie Fernandes et al.
Multiple myeloma (MM) is a complex hematologic malignancy characterized by the abnormal proliferation of plasma cells in the bone marrow, leading to significant clinical challenges and a high burden of morbidity and mortality. Interleukin 1...
Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancer [0.03%]
液体活检领域的拓展-肾细胞癌和膀胱癌循环生物标志物的鉴定与验证
Sabareeswaran Krishnan,Shruthi Kanthaje,Punchappady Devasya Rekha et al.
Sabareeswaran Krishnan et al.
Renal cell carcinoma (RCC) and Bladder cancer (BC) are two lethal urological cancers that require diagnosis at their earliest stage causing decreasing survival rates in case of aggressive disease. However, there is no reliable circulating m...
Circulating biomarkers for diagnosis and response to therapies in cancer patients [0.03%]
癌症患者的循环生物标志物用于诊断和评估治疗反应
Natália Marcéli Stefanes,Maria Eduarda Cunha-Silva,Lisandra de Oliveira Silva et al.
Natália Marcéli Stefanes et al.
Cancer presents a significant challenge to global health, driving worldwide concerted efforts to advance early detection, predict therapeutic response, and identify novel targeted therapies. Liquid biopsies emerge as promising avenues for d...
Lorenzo Galluzzi,Sheila Spada
Lorenzo Galluzzi
DOGMA-seq and multimodal, single-cell analysis in acute myeloid leukemia [0.03%]
单细胞DOGMASEQ和多模态急性髓系白血病分析法
JangKeun Kim,Nathan Schanzer,Ruth Subhash Singh et al.
JangKeun Kim et al.
Acute myeloid leukemia (AML) is a complex cancer, yet advances in recent years from integrated genomics methods have helped improve diagnosis, treatment, and means of patient stratification. A recent example of a powerful, multimodal method...
Elisa-Elvira Figueroa-Angulo,Jonathan Puente-Rivera,Yussel Fernando Perez-Navarro et al.
Elisa-Elvira Figueroa-Angulo et al.
The critical role of a subset of Human Papillomavirus in cervical cancer has been widely acknowledged and studied. Despite progress in our understanding of the viral molecular mechanisms of pathogenesis, knowledge of how infection with HPV ...
Epigenetic modulation of doxorubicin resistance and strategies for enhancing chemotherapeutic sensitivity [0.03%]
表观遗传调控多柔比星耐药及增强化疗敏感性的策略研究进展
Sruthi Sritharan,Nageswaran Sivalingam
Sruthi Sritharan
With the rising global cancer burden, the dependency on chemotherapy also rises along with the complication of chemoresistance development. Studies on multi-drug resistant proteins provide a wide range of regulators, although the exact mech...
The translational potential of epigenetic modulatory bioactive phytochemicals as adjuvant therapy against cancer [0.03%]
表观遗传调控活性植物化学物质作为癌症辅助治疗的转化潜力
Priya Mondal,Gowthami Jayaprakash,Syed Musthapa Meeran
Priya Mondal
In preclinical studies, bioactive phytochemicals have shown enormous potential therapeutic efficacy against various human malignancies. These natural compounds have been shown to possess an inherent potential to alter the molecular signalin...
Role of miRNAs as epigenetic regulators of immune checkpoints in lung cancer immunity [0.03%]
微小核糖核酸在肺癌免疫中作为免疫检查点表观遗传调控因子的作用
Irene Cánovas-Cervera,Elena Nacher-Sendra,Guillermo Suay et al.
Irene Cánovas-Cervera et al.
The advent of immunotherapy in cancer has provided new avenues in the treatment of many malignancies at various stages. Specifically, immune checkpoint inhibitors (ICIs) have transformed the field of lung cancer treatment. However, since so...
Revisiting epigenetic regulation in cancer: Evolving trends and translational implications [0.03%]
癌症表观遗传调控的再思考：发展趋势与转化意义
Mohammad Afsar Khan,Dhruv Mishra,Ranjan Kumar et al.
Mohammad Afsar Khan et al.
Cancer is a leading cause of mortality worldwide. The evolving role of epigenetics and tumor microenvironments of cancer pose significant challenges to the management of cancer. Besides genetics, epigenetic changes play a crucial role in th...