Jingbin Zhuang,Yuli Guo,Houjian Zhang et al.
Jingbin Zhuang et al.
Purpose: To explore the role of the Hippo signaling pathway in the regeneration of corneal endothelial cells (CECs) and to evaluate the pro-regenerative potential of pharmacological inhibition of this pathway across speci...
Integrated tear vitamin D-IL-6-NRF2 signature associated with keratoconus severity: An exploratory cross-sectional study [0.03%]
与角膜扩张严重程度相关的综合眼泪维生素D-IL-6-NRF2标志物：一项探索性横断面研究
Renato Galão Cerquinho Leça,Fernando Luiz Affonso Fonseca,Glaucia Raquel Luciano da Veiga et al.
Renato Galão Cerquinho Leça et al.
Purpose: Tear-based biomarkers with consistent, severity-graded associations remain lacking in keratoconus. We examined, in an exploratory cross-sectional design, the association between tear vitamin D deficiency and dise...
Lipocalin 2 as a novel target of pralatrexate mitigating corneal epithelial damage in a mouse model of herpes simplex keratitis [0.03%]
新型抗病毒药物普拉替雷塞通过靶向脂联素2减轻疱疹性角膜炎小鼠模型的上皮损伤
Jing Wu,Ruining Lyu,Li Chen et al.
Jing Wu et al.
Herpes simplex keratitis (HSK), a sight-threatening ocular infection caused by herpes simplex virus (HSV), primarily induces blindness through corneal damage driven by the lytic death of infected epithelial cells. Only a limited number of a...
Rare and emerging bacterial and fungal pathogens in infectious keratitis [0.03%]
角膜感染中罕见及新出现的细菌和真菌病原体
Prathishtha Pitchyaiah,Rachel A F Wozniak
Prathishtha Pitchyaiah
Infectious keratitis (IK, corneal infection) is a major contributor to blindness worldwide and can be caused by a diversity of pathogens including bacteria, fungi, viruses, and protozoa. Through numerous large scale epidemiology studies, co...
Familial Keratoconus Across Three Generations: Co-segregation of a COL11A1 c.3185G>A (p.Arg1062His) Variant [0.03%]
三代家族性角膜 keratoconus 的遗传特征：成胶原蛋白 XIα1 链COL11A1基因c.3185G>A(p.Arg1062His)变异共分离现象
T T Tanios,Rosalia Antunes-Foschini,Marcony R Santhiago et al.
T T Tanios et al.
High-resolution thermography shows real-time dynamic tear film formation [0.03%]
高分辨率热图测量法展示实时泪膜动态形成过程
Timon Ax,Joseph Descallar,Tomas L Bothe et al.
Timon Ax et al.
Purpose: The purpose of this study was to compare the thermographic tear film spread dynamics with the tear film lipid layer dynamics observed with interferometry. This was done to test the hypothesis that the spread of t...
Clinical feasibility of hyperspectral imaging for evaluation of anterior segment disorders [0.03%]
基于光谱图像的眼前段疾病诊断的临床可行性研究
Caroline Karlsson,Linn Engqvist,Michelle Müller et al.
Caroline Karlsson et al.
Purpose: To evaluate the feasibility of hyperspectral imaging (HSI) for non-invasive characterization of pathological conditions in the human anterior segment and to explore its use alongside laser speckle contrast imagin...
A post-HSCT ocular surface "Window of Opportunity for Pre-emptive ocular treatment" (WinOP) shows early inflammatory activation and an oGVHD-like molecular subset [0.03%]
眼科移植后HSCT眼表“预后治疗机会窗口”(WinOP)显示早期炎症活化和类oGVHD分子亚型
Zeenal Dabre,Christine Mun,Hyung-Geun Moon et al.
Zeenal Dabre et al.
Purpose: To describe the early post-hematopoietic stem cell transplant (HSCT) "window of opportunity for pre-emptive ocular treatment" (WinOP) and assess whether WinOP patients show an ocular GVHD (oGVHD)-like profile bef...
Gary D Novack
Gary D Novack
The ocular surface consequences of lacrimal gland loss are life-stage dependent [0.03%]
泪腺丧失对眼表的影响随生命周期而定
Jiaxu Han,Ren Liu,Caizhen Qiu et al.
Jiaxu Han et al.
Purpose: This study aimed to characterize the clinical manifestations of congenital isolated lacrimal gland aplasia (LGA) and to elucidate the life-stage-dependent effects of lacrimal gland (LG) loss on ocular surface hom...