Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208) [0.03%]
BET蛋白抑制剂Apabetalone（RVX-208）通过体外，小鼠和心血管疾病患者下调补体级联反应
Sylwia Wasiak,Dean Gilham,Laura M Tsujikawa et al.
Sylwia Wasiak et al.
Apabetalone (RVX-208) is an epigenetic regulator developed to treat cardiovascular disease (CVD) that targets BET proteins. Through transcriptional regulation RVX-208 modulates pathways that underlie CVD including reverse cholesterol transp...
Hui Pang,Bing Han,Qiang Fu et al.
Hui Pang et al.
Hypertension plays a significant role in the development of atrial fibrillation (AF) and its complications. The coexistence of the two diseases increases the risk of thromboembolism events. Although CHADS2 and CHA2DS2-VASc scores have been ...
Exome Sequencing Identifies Candidate Genetic Modifiers of Syndromic and Familial Thoracic Aortic Aneurysm Severity [0.03%]
外显子组测序鉴定出一组遗传修饰因子，该修饰因子可修饰综合征性和家族性胸主动脉瘤的严重度
Benjamin J Landis,Jeffrey A Schubert,Dongbing Lai et al.
Benjamin J Landis et al.
Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was perfo...
Adrian H Chester
Adrian H Chester
Various Regulatory Modes for Circadian Rhythmicity and Sexual Dimorphism in the Non-Neuronal Cardiac Cholinergic System [0.03%]
心肌胆碱能系统的昼夜节律性和性别二态性的各种调节模式
Shino Oikawa,Yuko Kai,Asuka Mano et al.
Shino Oikawa et al.
Cardiomyocytes possess a non-neuronal cardiac cholinergic system (NNCCS) regulated by a positive feedback system; however, its other regulatory mechanisms remain to be elucidated, which include the epigenetic control or regulation by the fe...
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy [0.03%]
_NOTCH配体DLL1和periostin与扩张型心肌病的症状严重程度和舒张功能有关
Hilde M Norum,Kaspar Broch,Annika E Michelsen et al.
Hilde M Norum et al.
In dilated cardiomyopathy (DCM), adverse myocardial remodeling is essential, potentially involving Notch signaling. We hypothesized that secreted Notch ligands would be dysregulated in DCM. We measured plasma levels of the canonical Delta-l...
Development and Characterization of a Porcine Mitral Valve Scaffold for Tissue Engineering [0.03%]
组织工程学用猪二尖瓣支架的开发与表征
M Granados,L Morticelli,S Andriopoulou et al.
M Granados et al.
Decellularized scaffolds represent a promising alternative for mitral valve (MV) replacement. This work developed and characterized a protocol for the decellularization of whole MVs. Porcine MVs were decellularized with 0.5% (w/v) SDS and 0...
Disaggregation Following Agonist-Induced Platelet Activation in Patients on Dual Antiplatelet Therapy [0.03%]
双重抗血小板治疗患者活化诱导的血小板解聚研究
Patricia P Wadowski,Beate Eichelberger,Christoph W Kopp et al.
Patricia P Wadowski et al.
Disaggregation as the difference between maximal and final platelet aggregation by light transmission aggregometry indicates the stability of platelet aggregates. We evaluated the extent of disaggregation after platelet stimulation with ade...
Deep Phenotyping of Systemic Arterial Hemodynamics in HFpEF (Part 2): Clinical and Therapeutic Considerations [0.03%]
射血分数保留的心力衰竭（HFpEF）的深表型研究（第2部分）：临床和治疗考虑因素
Julio A Chirinos
Julio A Chirinos
Multiple phase III trials over the last few decades have failed to demonstrate a clear benefit of various pharmacologic interventions in heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF). Therefore, a better und...