Teresa Simon-Yarza,Isabelle Bataille,Didier Letourneur
Teresa Simon-Yarza
Despite the introduction of new drugs and innovative devices contributing in the last years to improve patients' quality of life, morbidity and mortality from cardiovascular diseases remain high. There is an urgent need for addressing the u...
Phenomapping for the Identification of Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection Fraction [0.03%]
高血压患者心力衰竭前期的心肌底物的表型识别分析
Daniel H Katz,Rahul C Deo,Frank G Aguilar et al.
Daniel H Katz et al.
We sought to evaluate whether unbiased machine learning of dense phenotypic data ("phenomapping") could identify distinct hypertension subgroups that are associated with the myocardial substrate (i.e., abnormal cardiac mechanics) for heart ...
Fixation of Bovine Pericardium-Based Tissue Biomaterial with Irreversible Chemistry Improves Biochemical and Biomechanical Properties [0.03%]
不可逆化学固定法可改善牛心包组织生物材料的理化和力学性能
H Tam,W Zhang,D Infante et al.
H Tam et al.
Bioprosthetic heart valves (BHVs), derived from glutaraldehyde crosslinked (GLUT) porcine aortic valve leaflets or bovine pericardium (BP), are used to replace defective heart valves. However, valve failure can occur within 12-15 years due ...
Deep Phenotyping of Systemic Arterial Hemodynamics in HFpEF (Part 1): Physiologic and Technical Considerations [0.03%]
HFpEF动脉血流动力学表型的深度刻画（上篇）：生理及技术考量
Julio A Chirinos
Julio A Chirinos
A better understanding of the pathophysiology of heart failure with a preserved left ventricular ejection fraction (HFpEF) is important. Detailed phenotyping of pulsatile hemodynamics has provided important insights into the pathophysiology...
Utilizing the Foreign Body Response to Grow Tissue Engineered Blood Vessels in Vivo [0.03%]
利用外来体反应在生物体内生长组织工程血管
Wouter J Geelhoed,Lorenzo Moroni,Joris I Rotmans
Wouter J Geelhoed
It is well known that the number of patients requiring a vascular grafts for use as vessel replacement in cardiovascular diseases, or as vascular access site for hemodialysis is ever increasing. The development of tissue engineered blood ve...
Impaired Tissue Oxygenation in Metabolic Syndrome Requires Increased Microvascular Perfusion Heterogeneity [0.03%]
代谢综合征的组织氧合障碍需要增加微血管灌注异质性
P Mason McClatchey,Fan Wu,I Mark Olfert et al.
P Mason McClatchey et al.
Metabolic syndrome (MS) in obese Zucker rats (OZR) is associated with impaired skeletal muscle performance and blunted hyperemia. Studies suggest that reduced O2 diffusion capacity is required to explain compromised muscle performance and t...
Usefulness of Genetic Testing in Hypertrophic Cardiomyopathy: an Analysis Using Real-World Data [0.03%]
hypertrophic心肌病遗传检测的实用性：基于真实世界数据的分析
M Alejandra Restrepo-Cordoba,Oscar Campuzano,Tomás Ripoll-Vera et al.
M Alejandra Restrepo-Cordoba et al.
This study sought to determine the usefulness of genetic testing to predict evolution in hypertrophic cardiomyopathy (HCM) and to assess the role of genetic testing in clinical practice. Genetic results of 100 HCM patients tested for mutati...
Tensor Factorization for Precision Medicine in Heart Failure with Preserved Ejection Fraction [0.03%]
用于射血分数保留的心力衰竭的精准医学张量因子分解方法
Yuan Luo,Faraz S Ahmad,Sanjiv J Shah
Yuan Luo
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome that may benefit from improved subtyping in order to better characterize its pathophysiology and to develop novel targeted therapies. The United Sta...
Implantation of a Poly-L-Lactide GCSF-Functionalized Scaffold in a Model of Chronic Myocardial Infarction [0.03%]
聚-DL-乳酸粒细胞集落刺激因子功能化支架在慢性心肌梗死模型中成形性研究
Cristiano Spadaccio,Francesco Nappi,Federico De Marco et al.
Cristiano Spadaccio et al.
A previously developed poly-L-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch. Control groups were constituted by healthy...
Phenotype-Specific Association of Single-Nucleotide Polymorphisms with Heart Failure and Preserved Ejection Fraction: a Genome-Wide Association Analysis of the Cardiovascular Health Study [0.03%]
针对射血分数保留型心力衰竭的单核苷酸多态性全基因组关联研究：心血管健康研究中的表型特异性相关性分析
David P Kao,Laura M Stevens,Michael A Hinterberg et al.
David P Kao et al.
Little is known about genetics of heart failure with preserved ejection fraction (HFpEF) in part because of the many comorbidities in this population. To identify single-nucleotide polymorphisms (SNPs) associated with HFpEF, we analyzed phe...