Disaggregation Following Agonist-Induced Platelet Activation in Patients on Dual Antiplatelet Therapy [0.03%]
双重抗血小板治疗患者活化诱导的血小板解聚研究
Patricia P Wadowski,Beate Eichelberger,Christoph W Kopp et al.
Patricia P Wadowski et al.
Disaggregation as the difference between maximal and final platelet aggregation by light transmission aggregometry indicates the stability of platelet aggregates. We evaluated the extent of disaggregation after platelet stimulation with ade...
Deep Phenotyping of Systemic Arterial Hemodynamics in HFpEF (Part 2): Clinical and Therapeutic Considerations [0.03%]
射血分数保留的心力衰竭（HFpEF）的深表型研究（第2部分）：临床和治疗考虑因素
Julio A Chirinos
Julio A Chirinos
Multiple phase III trials over the last few decades have failed to demonstrate a clear benefit of various pharmacologic interventions in heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF). Therefore, a better und...
Sustained Placental Growth Factor-2 Treatment Does Not Aggravate Advanced Atherosclerosis in Ischemic Cardiomyopathy [0.03%]
持续的胎盘生长因子-2治疗不会加重缺血性心肌病患者的动脉粥样硬化病情
Ming Wu,Peter Pokreisz,Melissa Swinnen et al.
Ming Wu et al.
Angiogenic growth factor therapy for ischemic cardiovascular disease carries a risk of stimulating atherosclerotic plaque growth. We evaluated risk benefit ratio of sustained administration of recombinant human placental growth factor (rhPl...
The Dynamics of Cardiovascular Biomarkers in non-Elite Marathon Runners [0.03%]
半职业马拉松运动员的心血管生物标志物动力学研究
Emma Roca,Lexa Nescolarde,Josep Lupón et al.
Emma Roca et al.
The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barc...
Radiofrequency Ablation of the Atherosclerotic Plaque: a Proof of Concept Study in an Atherosclerotic Model [0.03%]
动脉粥样硬化斑块射频消融的可行性研究：动脉粥样硬化的动物模型实验研究
Guilielmus H J M Ellenbroek,Gerardus P J van Hout,Saskia C A de Jager et al.
Guilielmus H J M Ellenbroek et al.
Increased plaque vascularization is causatively associated with the progression of unstable atherosclerotic vessel disease. We investigated the safety and efficacy of heat-generating radiofrequency ablation (RFA) in reducing the number of v...
Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up [0.03%]
基于干细胞球体的类器官芯片技术及其扩增
Isotta Chimenti,Diana Massai,Umberto Morbiducci et al.
Isotta Chimenti et al.
Improved protocols/devices for in vitro culture of 3D cell spheroids may provide essential cues for proper growth and differentiation of stem/progenitor cells (S/PCs) in their niche, allowing preservation of specific features, such as multi...
Mimicking Cardiac Fibrosis in a Dish: Fibroblast Density Rather than Collagen Density Weakens Cardiomyocyte Function [0.03%]
模仿心脏纤维化：成纤维细胞密度而非胶原蛋白密度会削弱心肌细胞功能
Ariane C C van Spreeuwel,Noortje A M Bax,Bastiaan J van Nierop et al.
Ariane C C van Spreeuwel et al.
Cardiac fibrosis is one of the most devastating effects of cardiac disease. Current in vitro models of cardiac fibrosis do not sufficiently mimic the complex in vivo environment of the cardiomyocyte. We determined the local composition and ...
Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein A12B to Prevent Ventricular Dysfunction Following Acute Myocardial Infarction in Diabetic Rats [0.03%]
热休克蛋白A12B通过调节A-激酶锚定蛋白12预防急性心肌梗死后糖尿病大鼠的室性心律失常及心功能障碍
Vaithinathan Selvaraju,Sumanth C Suresh,Mahesh Thirunavukkarasu et al.
Vaithinathan Selvaraju et al.
We examined the effects of overexpressing HSPA12B on angiogenesis and myocardial function by intramyocardial administration of adenovirus encoding HSPA12B (Ad. HSPA12B) in a streptozotocin-induced diabetic rat subjected to myocardial infarc...
Decellularized Cryopreserved Allografts as Off-the-Shelf Allogeneic Alternative for Heart Valve Replacement: In Vitro Assessment Before Clinical Translation [0.03%]
脱细胞冷冻同种异体移植物作为心脏瓣膜置换术的现货型同种异体替代品：在临床转化前的体外评估
Laura Iop,Adolfo Paolin,Paola Aguiari et al.
Laura Iop et al.
Cryopreserved allogeneic conduits are the elective biocompatible choice among currently available substitutes for surgical replacement in end-stage valvulopathy. However, degeneration occurs in 15 years in adults or faster in children, due ...
Maximilian Y Emmert,Emanuela S Fioretta,Simon P Hoerstrup
Maximilian Y Emmert
Valvular heart disease and congenital heart defects represent a major cause of death around the globe. Although current therapy strategies have rapidly evolved over the decades and are nowadays safe, effective, and applicable to many affect...